SCMC2_XENTR
ID SCMC2_XENTR Reviewed; 513 AA.
AC Q5XH95;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Calcium-binding mitochondrial carrier protein SCaMC-2;
DE AltName: Full=Small calcium-binding mitochondrial carrier protein 2;
DE AltName: Full=Solute carrier family 25 member 25;
GN Name=slc25a25; Synonyms=scamc2;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Calcium-dependent mitochondrial solute carrier.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; BC084177; AAH84177.1; -; mRNA.
DR RefSeq; NP_001011052.1; NM_001011052.1.
DR AlphaFoldDB; Q5XH95; -.
DR SMR; Q5XH95; -.
DR STRING; 8364.ENSXETP00000016859; -.
DR PaxDb; Q5XH95; -.
DR DNASU; 496462; -.
DR GeneID; 496462; -.
DR KEGG; xtr:496462; -.
DR CTD; 114789; -.
DR Xenbase; XB-GENE-5933194; slc25a25.
DR eggNOG; KOG0036; Eukaryota.
DR HOGENOM; CLU_015166_2_0_1; -.
DR InParanoid; Q5XH95; -.
DR OMA; XIRTGHF; -.
DR OrthoDB; 442523at2759; -.
DR TreeFam; TF313492; -.
DR Proteomes; UP000008143; Chromosome 8.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005347; F:ATP transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002167; Graves_DC.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF13499; EF-hand_7; 2.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00928; GRAVESDC.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00054; EFh; 4.
DR SUPFAM; SSF103506; SSF103506; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 4.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Calcium; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..513
FT /note="Calcium-binding mitochondrial carrier protein SCaMC-
FT 2"
FT /id="PRO_0000317608"
FT TOPO_DOM 1..233
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..251
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..288
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..308
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..331
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..345
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 346..381
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..401
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 402..424
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..442
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 443..481
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 482..501
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 502..513
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT DOMAIN 55..90
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 91..124
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 122..157
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 158..193
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REPEAT 228..314
FT /note="Solcar 1"
FT REPEAT 322..407
FT /note="Solcar 2"
FT REPEAT 419..507
FT /note="Solcar 3"
FT BINDING 68
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 70
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 72
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 79
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 104
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 106
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 108
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 110
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 115
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 513 AA; 56640 MW; D49A0D6AF17E7512 CRC64;
MARPRSLVSP LLSGVFCQCD TVGGAPHTHD TPASPSLAAA LAADPCGGLV CGGPEHETRL
QILFQELDVN KDGGICINDL AVGLKRLGVH RTELELRKIV KAGDKDQDGQ LDFEEFVHYL
RDHEKKLRLV FKSLDKKNDG RIDAQEIMQS LRDLGVNISE QQAEKILKSM DKNGTMTIDW
NEWRDYHLLH PAENIPEIIL YWKHSTIFDV GENLLVPDEF TVEEKQTGMW WRHLVAGGGA
GAVSRTCTAP LDRLKVLMQV HASRSNNMSM LGGFTQMIRE GGIRSLWRGN GINVIKIAPE
SAIKFMAYEQ MKRIIGSDQE TLGIHERLVA GSLAGVIAQS SIYPMEVLKT RMALRKTGQY
QGMLDCGKKI LLKEGVSAFY KGYVPNMLGI IPYAGIDLAV YETLKNAWLQ RYATSSADPG
VFVLLACGTI SSTCGQLASY PLALVRTRMQ AEASVEGAPQ MTMSKLFKHI VKTEGAFGLY
RGLAPNFMKV IPAVSISYVV YENLKLTLGV QSR
