ID   SCML1_HOOHO             Reviewed;         329 AA.
AC   B0FZP1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Sex comb on midleg-like protein 1;
GN   Name=SCML1;
OS   Hoolock hoolock (Western hoolock gibbon) (Bunopithecus hoolock).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Hoolock.
OX   NCBI_TaxID=61851;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=18601738; DOI=10.1186/1471-2148-8-192;
RA   Wu H.-H., Su B.;
RT   "Adaptive evolution of SCML1 in primates, a gene involved in male
RT   reproduction.";
RL   BMC Evol. Biol. 8:192-192(2008).
CC   -!- FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by
CC       forming multiprotein complexes, which are required to maintain the
CC       transcriptionally repressive state of homeotic genes throughout
CC       development. May be involved in spermatogenesis during sexual
CC       maturation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SCM family. {ECO:0000305}.
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DR   EMBL; EU370785; ABY68580.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0FZP1; -.
DR   SMR; B0FZP1; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Nucleus; Phosphoprotein; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..329
FT                   /note="Sex comb on midleg-like protein 1"
FT                   /id="PRO_0000380547"
FT   DOMAIN          258..325
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   MOD_RES         138
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN30"
FT   MOD_RES         238
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN30"
SQ   SEQUENCE   329 AA;  37667 MW;  C4C46904F536FA01 CRC64;
     MMSSSSSEID VVKTRIPTYD EDDNTVLYAY ETKPEFVNKE PNIVSDVSCN TEEQQKTVND
     VLIHCQVIYD AMQNLDKKID VIRRKVSKIQ RFYVKSLWTN RKRYGYKKYS YRLAKKLKLK
     KMKKNEVYES FSYPESYSPT LPVSRCENNS PSNFPRPSFC MEEYRRAEPE EDPILSRTPS
     PVHPSDFSEH NYQPYYASDG ATYGSSSGTC RGNPRADGIH NTYSTDHASA APPSVARSPF
     ENDRYIEEGS ITKHPSTWSV EAVVLFLKQT DPLALCPLID LFRSHEIDGK ALLLLTSDVL
     LKHLGVKLGT AVKLCYYIDR LKQGKCFEN