ID   SCML1_MACMU             Reviewed;         329 AA.
AC   B0FZP2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Sex comb on midleg-like protein 1;
GN   Name=SCML1;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RX   PubMed=18601738; DOI=10.1186/1471-2148-8-192;
RA   Wu H.-H., Su B.;
RT   "Adaptive evolution of SCML1 in primates, a gene involved in male
RT   reproduction.";
RL   BMC Evol. Biol. 8:192-192(2008).
CC   -!- FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by
CC       forming multiprotein complexes, which are required to maintain the
CC       transcriptionally repressive state of homeotic genes throughout
CC       development. May be involved in spermatogenesis during sexual
CC       maturation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in testis and pancreas.
CC       Preferentially expressed in the germ stem cells of testis.
CC       {ECO:0000269|PubMed:18601738}.
CC   -!- DEVELOPMENTAL STAGE: Expression is decreased in adult compared to
CC       sexually immature individuals. {ECO:0000269|PubMed:18601738}.
CC   -!- SIMILARITY: Belongs to the SCM family. {ECO:0000305}.
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DR   EMBL; EU370786; ABY68581.1; -; Genomic_DNA.
DR   RefSeq; NP_001107584.1; NM_001114112.1.
DR   RefSeq; XP_014982459.1; XM_015126973.1.
DR   AlphaFoldDB; B0FZP2; -.
DR   SMR; B0FZP2; -.
DR   STRING; 9544.ENSMMUP00000016941; -.
DR   GeneID; 714239; -.
DR   KEGG; mcc:714239; -.
DR   CTD; 6322; -.
DR   eggNOG; KOG3766; Eukaryota.
DR   InParanoid; B0FZP2; -.
DR   OMA; YETKPEF; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..329
FT                   /note="Sex comb on midleg-like protein 1"
FT                   /id="PRO_0000380550"
FT   DOMAIN          258..325
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   REGION          125..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..156
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         138
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN30"
FT   MOD_RES         238
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN30"
SQ   SEQUENCE   329 AA;  37530 MW;  D94C97FB86CB75D0 CRC64;
     MMSSSSSEID VVKTRIPTYD EDDDTILYAY ETKPDFVNKE PNTVSDASCN TEEQQKTVND
     VLIHCQVIYD AMQNLDKKID VIRRKVSKIQ RFRARSLWTN RKRYGYKNYS YQLAKKLKRQ
     KMKKNEVHES FSYPESYSPT LPVSRRENNS PSNLPRPSFR MEEYQRAEPE EDPILSRTPS
     PVHPSDFSEH NYQPYYASDG AMHGSSSGPC LGNPGANSIY NTYSTDHASA AQPSVTSSPF
     ENDRYIEEGS ITKHPSTWSV EAVVLFLKQT DPLALCPLVD LFRSHEIDGK ALLLLTSDVL
     LKHLGVKLGT AVKLCYYIDR LKQGKCFEN