ID   SCML1_NOMLE             Reviewed;         329 AA.
AC   B0FZP0;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Sex comb on midleg-like protein 1;
GN   Name=SCML1;
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=18601738; DOI=10.1186/1471-2148-8-192;
RA   Wu H.-H., Su B.;
RT   "Adaptive evolution of SCML1 in primates, a gene involved in male
RT   reproduction.";
RL   BMC Evol. Biol. 8:192-192(2008).
CC   -!- FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by
CC       forming multiprotein complexes, which are required to maintain the
CC       transcriptionally repressive state of homeotic genes throughout
CC       development. May be involved in spermatogenesis during sexual
CC       maturation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SCM family. {ECO:0000305}.
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DR   EMBL; EU370784; ABY68579.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0FZP0; -.
DR   SMR; B0FZP0; -.
DR   STRING; 61853.ENSNLEP00000011721; -.
DR   eggNOG; KOG3766; Eukaryota.
DR   InParanoid; B0FZP0; -.
DR   Proteomes; UP000001073; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..329
FT                   /note="Sex comb on midleg-like protein 1"
FT                   /id="PRO_0000380549"
FT   DOMAIN          258..325
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   MOD_RES         138
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN30"
FT   MOD_RES         238
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN30"
SQ   SEQUENCE   329 AA;  37402 MW;  92E4CB19B9F0E0FE CRC64;
     MMSSSSSEID VVKTRIPTYD EDDNTVLYAY ETKPEFVNKE LNIVSDASCN TEEQQKTVND
     VLIHCQVIYD AMQNLDKKID VIRRKVSKIQ RFCVKSLWTN RKRYGYKKYS YRLAKKLKLK
     KMKKNEVYES FSYPESYSPT LPVSRCENNS PSNFPRPSFC MEEYRRAEPE EDPILSRTPS
     PVHPSDFSEH NYQPYYASDG ATYGSSSGTC RGNPRADGIH NTYSTDHASA APPSVTGSLF
     GNDCYIEEGS ITKHPSTWSV EAVVLFLKQT DPLALCPLVD LFRSHEIDGK ALLLLTSDVL
     LKHLGVKLGT AVKLCYYIDR LKQGKCFEN