ID   SCML1_PANTR             Reviewed;         329 AA.
AC   B0FZN7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Sex comb on midleg-like protein 1;
GN   Name=SCML1;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=18601738; DOI=10.1186/1471-2148-8-192;
RA   Wu H.-H., Su B.;
RT   "Adaptive evolution of SCML1 in primates, a gene involved in male
RT   reproduction.";
RL   BMC Evol. Biol. 8:192-192(2008).
CC   -!- FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by
CC       forming multiprotein complexes, which are required to maintain the
CC       transcriptionally repressive state of homeotic genes throughout
CC       development. May be involved in spermatogenesis during sexual
CC       maturation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SCM family. {ECO:0000305}.
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DR   EMBL; EU370781; ABY68576.1; -; Genomic_DNA.
DR   RefSeq; NP_001107636.1; NM_001114164.1.
DR   AlphaFoldDB; B0FZN7; -.
DR   SMR; B0FZN7; -.
DR   STRING; 9598.ENSPTRP00000047484; -.
DR   PaxDb; B0FZN7; -.
DR   GeneID; 465521; -.
DR   KEGG; ptr:465521; -.
DR   CTD; 6322; -.
DR   eggNOG; KOG3766; Eukaryota.
DR   InParanoid; B0FZN7; -.
DR   OrthoDB; 298184at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
PE   3: Inferred from homology;
KW   Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..329
FT                   /note="Sex comb on midleg-like protein 1"
FT                   /id="PRO_0000380551"
FT   DOMAIN          258..325
FT                   /note="SAM"
FT   REGION          138..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..155
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         138
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN30"
FT   MOD_RES         238
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN30"
SQ   SEQUENCE   329 AA;  37352 MW;  D183BAD8FD386D4F CRC64;
     MMSDSSSEID VVKTRIPTYD EDDNTILYAY ETKPEFVNKE PNIVSDASCN TEEQLRTVND
     VLLHCQVIYD ALQNLDKKTD VIRRKVSKIQ RFYARSLWTN RKRSGYKKHS YRPVKKLKLQ
     KMKKNEVYET FSYPQSYSPT LPVSRRENNS PSNLPRPPFC MEEYQRAEPE EDPILSRTPS
     PVHPSDFCEH NYQSYYASDG AMYGSSSGLC LGNPRADSIH NTYSTDHASA VSPSVTRSPV
     GNDGCIAEGN ITKHPSTWSV EAVVLFLKQT DPVALCPLVD LFRSHEVDGK ALLLLTSDVL
     LKHFGVKLGT AVKLCYYIDR LKQGKCFEN