ID   SCML1_PONPY             Reviewed;         329 AA.
AC   B0FZN9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Sex comb on midleg-like protein 1;
GN   Name=SCML1;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=18601738; DOI=10.1186/1471-2148-8-192;
RA   Wu H.-H., Su B.;
RT   "Adaptive evolution of SCML1 in primates, a gene involved in male
RT   reproduction.";
RL   BMC Evol. Biol. 8:192-192(2008).
CC   -!- FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by
CC       forming multiprotein complexes, which are required to maintain the
CC       transcriptionally repressive state of homeotic genes throughout
CC       development. May be involved in spermatogenesis during sexual
CC       maturation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SCM family. {ECO:0000305}.
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DR   EMBL; EU370783; ABY68578.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0FZN9; -.
DR   SMR; B0FZN9; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Nucleus; Phosphoprotein; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..329
FT                   /note="Sex comb on midleg-like protein 1"
FT                   /id="PRO_0000380552"
FT   DOMAIN          258..325
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   REGION          136..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..156
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         138
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN30"
FT   MOD_RES         238
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN30"
SQ   SEQUENCE   329 AA;  37532 MW;  2363FEFC74D1253D CRC64;
     MMSNSSSEID VVKTRIPTYD EDDDTILYAY ETKPEFVNKE PNIVSDASCN TEEQLKTVND
     VLIHCQVIYD AMQNLDKKID VIRRKVSKIQ RFHARSLWTN RKRYGYKKYS YRLAKKLKLQ
     KMKKNEVYES FSYPESYSPT LPVSRRENNS PSNLPRPSFC MEEYQPAEPE EDPILSRTPS
     PVHPSDFSEH NYQPYYASDG AMYGSSSGPC LGNPRADSIH NTYSTDHASA APPSVTRSPF
     ENDCYIKEGS ITKHPSTWSV EAVVLFLKQT DPVALCPLVD LFRSHEIDGK ALLLLTSDVL
     LKHLGVKLGT AVKLCYYIDR LKQGKCFEN