SCN1B_CANLF
ID SCN1B_CANLF Reviewed; 218 AA.
AC Q4PPC4;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Sodium channel subunit beta-1;
DE Flags: Precursor;
GN Name=SCN1B;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Mishra S., Sabbah H.N., Undrovinas N.A., Undrovinas A.I.;
RT "Cloning of dog cardiac sodium channel beta-1 subunit.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulatory subunit of multiple voltage-gated sodium channel
CC complexes that play important roles in excitable membranes in brain,
CC heart and skeletal muscle. Enhances the presence of the pore-forming
CC alpha subunit at the cell surface and modulates channel gating
CC characteristics and the rate of channel inactivation. Modulates the
CC activity of a variety of pore-forming alpha subunits, such as SCN1A,
CC SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. {ECO:0000250|UniProtKB:Q00954}.
CC -!- SUBUNIT: Component of a voltage-sensitive sodium channel complex that
CC consists of a pore-forming alpha subunit and one or more regulatory
CC beta subunits. Interacts with SCN4A. Interacts with NFASC. Interacts
CC with SCN10A (By similarity). Interacts with SCN1A. Interacts with
CC SCN3A. Interacts with SCN5A. Interacts with SCN8A (By similarity).
CC {ECO:0000250|UniProtKB:Q00954, ECO:0000250|UniProtKB:Q07699}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P97952};
CC Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q07699}.
CC Perikaryon {ECO:0000250|UniProtKB:P97952}. Cell projection
CC {ECO:0000250|UniProtKB:P97952}. Cell projection, axon
CC {ECO:0000250|UniProtKB:Q00954}. Note=Detected at nodes of Ranvier on
CC the sciatic nerve. {ECO:0000250|UniProtKB:P97952}.
CC -!- SIMILARITY: Belongs to the sodium channel auxiliary subunit SCN1B (TC
CC 8.A.17) family. {ECO:0000305}.
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DR EMBL; DQ061859; AAY59601.1; -; mRNA.
DR RefSeq; NP_001020569.1; NM_001025398.2.
DR AlphaFoldDB; Q4PPC4; -.
DR SMR; Q4PPC4; -.
DR STRING; 9615.ENSCAFP00000010590; -.
DR PaxDb; Q4PPC4; -.
DR Ensembl; ENSCAFT00000082522; ENSCAFP00000059779; ENSCAFG00000007129.
DR Ensembl; ENSCAFT00030003695; ENSCAFP00030003277; ENSCAFG00030002018.
DR Ensembl; ENSCAFT00040005243; ENSCAFP00040004509; ENSCAFG00040002747.
DR Ensembl; ENSCAFT00845006880; ENSCAFP00845005479; ENSCAFG00845003824.
DR GeneID; 484584; -.
DR KEGG; cfa:484584; -.
DR CTD; 6324; -.
DR VEuPathDB; HostDB:ENSCAFG00845003824; -.
DR VGNC; VGNC:45916; SCN1B.
DR eggNOG; ENOG502R0UM; Eukaryota.
DR GeneTree; ENSGT00390000018560; -.
DR InParanoid; Q4PPC4; -.
DR OrthoDB; 1345300at2759; -.
DR Reactome; R-CFA-5576892; Phase 0 - rapid depolarisation.
DR Proteomes; UP000002254; Chromosome 1.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; ISS:UniProtKB.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0019871; F:sodium channel inhibitor activity; IBA:GO_Central.
DR GO; GO:0017080; F:sodium channel regulator activity; ISS:UniProtKB.
DR GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IBA:GO_Central.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IBA:GO_Central.
DR GO; GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR027098; Na_channel_b1/b3.
DR InterPro; IPR044568; Na_chnl_b1.
DR PANTHER; PTHR10546; PTHR10546; 1.
DR PANTHER; PTHR10546:SF2; PTHR10546:SF2; 1.
DR Pfam; PF07686; V-set; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Ion channel; Ion transport; Membrane;
KW Reference proteome; Signal; Sodium; Sodium channel; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..218
FT /note="Sodium channel subunit beta-1"
FT /id="PRO_0000309743"
FT TOPO_DOM 19..160
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..218
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 22..150
FT /note="Ig-like C2-type"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 21..43
FT /evidence="ECO:0000250|UniProtKB:Q07699"
FT DISULFID 40..121
FT /evidence="ECO:0000250|UniProtKB:Q07699"
SQ SEQUENCE 218 AA; 24678 MW; A43902388FBFC944 CRC64;
MGTLLALVVG AALVSSAWGG CVEVDSETEA VYGMTFKILC ISCKRRSETT AETFTEWTFR
QKGTEEFVKI LRYENEVLQL EEDERFEGRV VWNGSRGTKD LQDLSIFITN VTYNHSGDYE
CHVYRLLFFE NYEHNTSVVK KIHIEVVDKA NRDMASIVSE IMMYVLIVVL TIWLVAEMVY
CYKKIAAATE AAAQENASEY LAITSESKEN CTGVQVAE
