ID   SCN1B_RABIT             Reviewed;         218 AA.
AC   P53788;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Sodium channel subunit beta-1;
DE   Flags: Precursor;
GN   Name=SCN1B;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Sciatic nerve;
RX   PubMed=8666261; DOI=10.1016/0378-1119(95)00871-3;
RA   Belcher S.M., Howe J.R.;
RT   "Cloning of the cDNA encoding the sodium channel beta 1 subunit from
RT   rabbit.";
RL   Gene 170:285-286(1996).
CC   -!- FUNCTION: Regulatory subunit of multiple voltage-gated sodium channel
CC       complexes that play important roles in excitable membranes in brain,
CC       heart and skeletal muscle. Enhances the presence of the pore-forming
CC       alpha subunit at the cell surface and modulates channel gating
CC       characteristics and the rate of channel inactivation. Modulates the
CC       activity of a variety of pore-forming alpha subunits, such as SCN1A,
CC       SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. {ECO:0000250|UniProtKB:Q00954}.
CC   -!- SUBUNIT: Component of a voltage-sensitive sodium channel complex that
CC       consists of a pore-forming alpha subunit and one or more regulatory
CC       beta subunits. Interacts with SCN4A. Interacts with NFASC. Interacts
CC       with SCN10A (By similarity). Interacts with SCN1A. Interacts with
CC       SCN3A. Interacts with SCN5A. Interacts with SCN8A (By similarity).
CC       {ECO:0000250|UniProtKB:Q00954, ECO:0000250|UniProtKB:Q07699}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P97952};
CC       Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q07699}.
CC       Perikaryon {ECO:0000250|UniProtKB:P97952}. Cell projection
CC       {ECO:0000250|UniProtKB:P97952}. Cell projection, axon
CC       {ECO:0000250|UniProtKB:Q00954}. Note=Detected at nodes of Ranvier on
CC       the sciatic nerve. {ECO:0000250|UniProtKB:P97952}.
CC   -!- SIMILARITY: Belongs to the sodium channel auxiliary subunit SCN1B (TC
CC       8.A.17) family. {ECO:0000305}.
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DR   EMBL; U35382; AAB17572.1; -; mRNA.
DR   PIR; JC4788; JC4788.
DR   RefSeq; NP_001075828.1; NM_001082359.1.
DR   AlphaFoldDB; P53788; -.
DR   SMR; P53788; -.
DR   STRING; 9986.ENSOCUP00000013138; -.
DR   GeneID; 100009211; -.
DR   KEGG; ocu:100009211; -.
DR   CTD; 6324; -.
DR   eggNOG; ENOG502R0UM; Eukaryota.
DR   InParanoid; P53788; -.
DR   OrthoDB; 1345300at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; ISS:UniProtKB.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0017080; F:sodium channel regulator activity; ISS:UniProtKB.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR027098; Na_channel_b1/b3.
DR   InterPro; IPR044568; Na_chnl_b1.
DR   PANTHER; PTHR10546; PTHR10546; 1.
DR   PANTHER; PTHR10546:SF2; PTHR10546:SF2; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Ion channel; Ion transport; Membrane;
KW   Reference proteome; Signal; Sodium; Sodium channel; Sodium transport;
KW   Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250"
FT   CHAIN           19..218
FT                   /note="Sodium channel subunit beta-1"
FT                   /id="PRO_0000014928"
FT   TOPO_DOM        19..160
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        183..218
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          22..150
FT                   /note="Ig-like C2-type"
FT   CARBOHYD        93
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        110
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        135
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        21..43
FT                   /evidence="ECO:0000250|UniProtKB:Q07699"
FT   DISULFID        40..121
FT                   /evidence="ECO:0000250|UniProtKB:Q07699"
SQ   SEQUENCE   218 AA;  24706 MW;  39BD174E1FAE7FD2 CRC64;
     MGRLLAFVVG AALVSSAWGG CVEVDSETEA VYGMTFKILC ISCKRRSETT AETFTEWTFR
     QKGTEEFVKI LRYENEVLQL EEDERFEGRV VWNGSRGTKD LQDLSIFITN VTYNHSGDYQ
     CHVYRLLSFE NYEHNTSVVK KIHLEVVDKA NRDMASIVSE IMMYVLIVVL TIWLVAEMVY
     CYKKIAAATE AAAQENASEY LAITSESKEN CTGVQVAE