SCN3B_BOVIN
ID SCN3B_BOVIN Reviewed; 215 AA.
AC Q2KI11;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Sodium channel subunit beta-3;
DE Flags: Precursor;
GN Name=SCN3B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Heart ventricle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Modulates channel gating kinetics. Causes unique persistent
CC sodium currents. Inactivates the sodium channel opening more slowly
CC than the subunit beta-1. Its association with NFASC may target the
CC sodium channels to the nodes of Ranvier of developing axons and retain
CC these channels at the nodes in mature myelinated axons (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: The voltage-sensitive sodium channel consists of an ion
CC conducting pore forming alpha-subunit regulated by one or more beta-1,
CC beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-
CC covalently associated with alpha, while beta-2 and beta-4 are
CC covalently linked by disulfide bonds (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- SIMILARITY: Belongs to the sodium channel auxiliary subunit SCN3B (TC
CC 8.A.17) family. {ECO:0000305}.
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DR EMBL; BC112810; AAI12811.1; -; mRNA.
DR RefSeq; NP_001039960.1; NM_001046495.1.
DR AlphaFoldDB; Q2KI11; -.
DR SMR; Q2KI11; -.
DR STRING; 9913.ENSBTAP00000022302; -.
DR BindingDB; Q2KI11; -.
DR PaxDb; Q2KI11; -.
DR Ensembl; ENSBTAT00000022302; ENSBTAP00000022302; ENSBTAG00000016768.
DR Ensembl; ENSBTAT00000073376; ENSBTAP00000066197; ENSBTAG00000016768.
DR GeneID; 540925; -.
DR KEGG; bta:540925; -.
DR CTD; 55800; -.
DR VEuPathDB; HostDB:ENSBTAG00000016768; -.
DR VGNC; VGNC:34349; SCN3B.
DR eggNOG; ENOG502QWH0; Eukaryota.
DR GeneTree; ENSGT00390000018560; -.
DR HOGENOM; CLU_096296_1_0_1; -.
DR InParanoid; Q2KI11; -.
DR OMA; LIFEYRN; -.
DR OrthoDB; 1198549at2759; -.
DR TreeFam; TF332097; -.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000016768; Expressed in cardiac ventricle and 69 other tissues.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR GO; GO:0019871; F:sodium channel inhibitor activity; IBA:GO_Central.
DR GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0086006; F:voltage-gated sodium channel activity involved in cardiac muscle cell action potential; IEA:Ensembl.
DR GO; GO:0086014; P:atrial cardiac muscle cell action potential; IEA:Ensembl.
DR GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IBA:GO_Central.
DR GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR GO; GO:0010765; P:positive regulation of sodium ion transport; IEA:Ensembl.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IBA:GO_Central.
DR GO; GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR GO; GO:0086015; P:SA node cell action potential; IEA:Ensembl.
DR GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR027098; Na_channel_b1/b3.
DR InterPro; IPR027096; Na_channel_b3.
DR PANTHER; PTHR10546; PTHR10546; 1.
DR PANTHER; PTHR10546:SF1; PTHR10546:SF1; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Ion channel;
KW Ion transport; Membrane; Reference proteome; Signal; Sodium;
KW Sodium channel; Sodium transport; Transmembrane; Transmembrane helix;
KW Transport; Voltage-gated channel.
FT SIGNAL 1..22
FT /evidence="ECO:0000250"
FT CHAIN 23..215
FT /note="Sodium channel subunit beta-3"
FT /id="PRO_0000254013"
FT TOPO_DOM 23..159
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..215
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 32..154
FT /note="Ig-like C2-type"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 121
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 26..48
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 45..120
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 215 AA; 24636 MW; E5BF3972F988AAD5 CRC64;
MPAFNRLFPL ASLLLILWVG VCFPVCVEVP SETEAVQGNP MKLRCISCMK REEVEATTVV
EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL QDVSITVLNV TLNDSGLYTC
NVSREFEFEA HRPFVKTTRL IPLRVTEEAG EDFTSVVSEI MMYILLVFLT LWLLIEMIYC
YRKVSKAEEA AQENASDYLA IPSENKENSA VPVEE