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SCN3B_BOVIN
ID   SCN3B_BOVIN             Reviewed;         215 AA.
AC   Q2KI11;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Sodium channel subunit beta-3;
DE   Flags: Precursor;
GN   Name=SCN3B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates channel gating kinetics. Causes unique persistent
CC       sodium currents. Inactivates the sodium channel opening more slowly
CC       than the subunit beta-1. Its association with NFASC may target the
CC       sodium channels to the nodes of Ranvier of developing axons and retain
CC       these channels at the nodes in mature myelinated axons (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The voltage-sensitive sodium channel consists of an ion
CC       conducting pore forming alpha-subunit regulated by one or more beta-1,
CC       beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-
CC       covalently associated with alpha, while beta-2 and beta-4 are
CC       covalently linked by disulfide bonds (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   -!- SIMILARITY: Belongs to the sodium channel auxiliary subunit SCN3B (TC
CC       8.A.17) family. {ECO:0000305}.
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DR   EMBL; BC112810; AAI12811.1; -; mRNA.
DR   RefSeq; NP_001039960.1; NM_001046495.1.
DR   AlphaFoldDB; Q2KI11; -.
DR   SMR; Q2KI11; -.
DR   STRING; 9913.ENSBTAP00000022302; -.
DR   BindingDB; Q2KI11; -.
DR   PaxDb; Q2KI11; -.
DR   Ensembl; ENSBTAT00000022302; ENSBTAP00000022302; ENSBTAG00000016768.
DR   Ensembl; ENSBTAT00000073376; ENSBTAP00000066197; ENSBTAG00000016768.
DR   GeneID; 540925; -.
DR   KEGG; bta:540925; -.
DR   CTD; 55800; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016768; -.
DR   VGNC; VGNC:34349; SCN3B.
DR   eggNOG; ENOG502QWH0; Eukaryota.
DR   GeneTree; ENSGT00390000018560; -.
DR   HOGENOM; CLU_096296_1_0_1; -.
DR   InParanoid; Q2KI11; -.
DR   OMA; LIFEYRN; -.
DR   OrthoDB; 1198549at2759; -.
DR   TreeFam; TF332097; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000016768; Expressed in cardiac ventricle and 69 other tissues.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IBA:GO_Central.
DR   GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0086006; F:voltage-gated sodium channel activity involved in cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0086014; P:atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IBA:GO_Central.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0010765; P:positive regulation of sodium ion transport; IEA:Ensembl.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IBA:GO_Central.
DR   GO; GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0086015; P:SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR027098; Na_channel_b1/b3.
DR   InterPro; IPR027096; Na_channel_b3.
DR   PANTHER; PTHR10546; PTHR10546; 1.
DR   PANTHER; PTHR10546:SF1; PTHR10546:SF1; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Ion channel;
KW   Ion transport; Membrane; Reference proteome; Signal; Sodium;
KW   Sodium channel; Sodium transport; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..215
FT                   /note="Sodium channel subunit beta-3"
FT                   /id="PRO_0000254013"
FT   TOPO_DOM        23..159
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..215
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          32..154
FT                   /note="Ig-like C2-type"
FT   CARBOHYD        95
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        109
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        113
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        121
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        26..48
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        45..120
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   215 AA;  24636 MW;  E5BF3972F988AAD5 CRC64;
     MPAFNRLFPL ASLLLILWVG VCFPVCVEVP SETEAVQGNP MKLRCISCMK REEVEATTVV
     EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL QDVSITVLNV TLNDSGLYTC
     NVSREFEFEA HRPFVKTTRL IPLRVTEEAG EDFTSVVSEI MMYILLVFLT LWLLIEMIYC
     YRKVSKAEEA AQENASDYLA IPSENKENSA VPVEE
 
 
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