SCN4B_BOVIN
ID SCN4B_BOVIN Reviewed; 228 AA.
AC Q08E08;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Sodium channel subunit beta-4;
DE Flags: Precursor;
GN Name=SCN4B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Brain cortex;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Modulates channel gating kinetics. Causes negative shifts in
CC the voltage dependence of activation of certain alpha sodium channels,
CC but does not affect the voltage dependence of inactivation. Modulates
CC the susceptibility of the sodium channel to inhibition by toxic
CC peptides from spider, scorpion, wasp and sea anemone venom (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: The voltage-sensitive sodium channel consists of an ion
CC conducting pore forming alpha-subunit (SCN2A) regulated by one or more
CC beta subunits (SCN1B, SCN2B, SCN3B and SCN4B). SCN1B and SCN3B are non-
CC covalently associated with SCN2A. SCN2B and SCN4B are disulfide-linked
CC to SCN2A (By similarity). {ECO:0000250|UniProtKB:Q8IWT1}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- PTM: Contains an interchain disulfide bond with SCN2A. {ECO:0000250}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the sodium channel auxiliary subunit SCN4B (TC
CC 8.A.17) family. {ECO:0000305}.
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DR EMBL; BC123479; AAI23480.1; -; mRNA.
DR RefSeq; NP_001070380.1; NM_001076912.1.
DR AlphaFoldDB; Q08E08; -.
DR SMR; Q08E08; -.
DR STRING; 9913.ENSBTAP00000017826; -.
DR PaxDb; Q08E08; -.
DR Ensembl; ENSBTAT00000017826; ENSBTAP00000017826; ENSBTAG00000039340.
DR GeneID; 538100; -.
DR KEGG; bta:538100; -.
DR CTD; 6330; -.
DR VEuPathDB; HostDB:ENSBTAG00000039340; -.
DR VGNC; VGNC:34351; SCN4B.
DR eggNOG; ENOG502QTZ6; Eukaryota.
DR GeneTree; ENSGT01030000234556; -.
DR HOGENOM; CLU_104235_0_0_1; -.
DR InParanoid; Q08E08; -.
DR OMA; EGQYICF; -.
DR OrthoDB; 1219179at2759; -.
DR TreeFam; TF331728; -.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000039340; Expressed in longissimus thoracis muscle and 93 other tissues.
DR ExpressionAtlas; Q08E08; baseline and differential.
DR GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR GO; GO:0031226; C:intrinsic component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; ISS:UniProtKB.
DR GO; GO:0017080; F:sodium channel regulator activity; ISS:UniProtKB.
DR GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0086006; F:voltage-gated sodium channel activity involved in cardiac muscle cell action potential; IEA:Ensembl.
DR GO; GO:0086016; P:AV node cell action potential; IEA:Ensembl.
DR GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IBA:GO_Central.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0010765; P:positive regulation of sodium ion transport; IEA:Ensembl.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR GO; GO:2000649; P:regulation of sodium ion transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000920; Myelin_P0-rel.
DR InterPro; IPR044572; Na_channel_b4.
DR PANTHER; PTHR13869; PTHR13869; 1.
DR PANTHER; PTHR13869:SF14; PTHR13869:SF14; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Ion channel; Ion transport; Membrane; Reference proteome; Signal; Sodium;
KW Sodium channel; Sodium transport; Transmembrane; Transmembrane helix;
KW Transport; Voltage-gated channel.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..228
FT /note="Sodium channel subunit beta-4"
FT /id="PRO_0000309745"
FT TOPO_DOM 31..162
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..148
FT /note="Ig-like C2-type"
FT REGION 198..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 53..131
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 58
FT /note="Interchain; with alpha subunit"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 228 AA; 25144 MW; FD5AEED1919F7391 CRC64;
MPGARDQGAA RARWLGIGLL GLFLLPVSLS LEVSVGKATT IYAVNGTEIL LPCTFSSCFG
FENLHFWWSY NSSDTYKILI DGTVKNEKSD PKVKLKDDDR ITLEGSTKEK MNNISISLKN
LEFSDTGKYT CHVKNPKEND FQHQATIFLQ VVDKLEEVDN TVTLIILGVV GGVIGLLIFI
LLVKKFIAFI IKKTQEKKKE CLVSSSGNDN TENGLPGSKA EEKAPTKV
