SCN60_DROME
ID SCN60_DROME Reviewed; 2844 AA.
AC Q9W0Y8; A0A0B4KF50; A9NIV8; Q27930; Q7JN09; Q7JN86; Q7JN87; Q7JN88; Q7JN89;
AC Q7K324; Q8MMC7;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2018, sequence version 6.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Sodium channel protein 60E;
DE AltName: Full=Drosophila ion channel 60;
DE AltName: Full=Drosophila sodium channel 1;
DE AltName: Full=Protein smell-impaired 60E;
DE AltName: Full=Sodium channel 2;
DE Short=DmNav2;
GN Name=NaCP60E;
GN Synonyms=DIC60 {ECO:0000312|EMBL:CAA59129.1},
GN DSC1 {ECO:0000303|PubMed:8083728}, smi60E {ECO:0000303|PubMed:12196396};
GN ORFNames=CG34405;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM P), AND RNA EDITING OF POSITION 2025.
RA Song W., Liu Z., Nomura Y., Dong K.;
RT "Functional characterization of the DSC1 channel.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305, ECO:0000312|EMBL:CAA32567.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-924 AND 1736-2430.
RX PubMed=2444928; DOI=10.1093/nar/15.20.8569;
RA Salkoff L., Butler A., Scavarda N., Wei A.;
RT "Nucleotide sequence of the putative sodium channel gene from Drosophila:
RT the four homologous domains.";
RL Nucleic Acids Res. 15:8569-8572(1987).
RN [5] {ECO:0000305, ECO:0000312|EMBL:CAA59129.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2181-2316.
RA Okamoto H., Sakai K., Goto S., Takasu-Ishikawa E., Hotta Y.;
RT "Isolation of Drosophila genomic clones homologous to the Eel sodium
RT channel gene.";
RL Proc. Jpn. Acad., B, Phys. Biol. Sci. 63:284-288(1987).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2164-2844 (ISOFORM G).
RC STRAIN=Berkeley; TISSUE=Head {ECO:0000312|EMBL:AAL25396.1};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [7] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=8083728; DOI=10.1523/jneurosci.14-09-05160.1994;
RA Hong C.S., Ganetzky B.;
RT "Spatial and temporal expression patterns of two sodium channel genes in
RT Drosophila.";
RL J. Neurosci. 14:5160-5169(1994).
RN [8] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=12196396; DOI=10.1093/genetics/161.4.1507;
RA Kulkarni N.H., Yamamoto A.H., Robinson K.O., Mackay T.F.C., Anholt R.R.;
RT "The DSC1 channel, encoded by the smi60E locus, contributes to odor-guided
RT behavior in Drosophila melanogaster.";
RL Genetics 161:1507-1516(2002).
RN [9] {ECO:0000305}
RP RNA EDITING OF POSITION 2025.
RX PubMed=12907802; DOI=10.1126/science.1086763;
RA Hoopengardner B., Bhalla T., Staber C., Reenan R.;
RT "Nervous system targets of RNA editing identified by comparative
RT genomics.";
RL Science 301:832-836(2003).
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Plays a role in processing of olfactory
CC information during the olfactory avoidance response.
CC {ECO:0000269|PubMed:12196396}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:12196396};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=G {ECO:0000312|FlyBase:FBgn0085434}; Synonyms=H
CC {ECO:0000312|FlyBase:FBgn0085434};
CC IsoId=Q9W0Y8-1; Sequence=Displayed;
CC Name=P {ECO:0000312|FlyBase:FBgn0085434};
CC IsoId=Q9W0Y8-3; Sequence=VSP_059322, VSP_059323;
CC -!- TISSUE SPECIFICITY: In embryonic and larval stages, expression is
CC limited to very few non-neuronal cells in either the CNS or PNS. In
CC pupal and adult stages, expressed in cell bodies of the fly central
CC nervous system, including optic lobes, central brain, subesophageal
CC ganglion, thoracico-abdominal ganglion, major olfactory organs, the
CC third antennal segment and the maxillary palps.
CC {ECO:0000269|PubMed:12196396, ECO:0000269|PubMed:8083728}.
CC -!- DOMAIN: The sequence contains 4 internal repeats, each with 5
CC hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged
CC segment (S4). Segments S4 are probably the voltage-sensors and are
CC characterized by a series of positively charged amino acids at every
CC third position. {ECO:0000305}.
CC -!- RNA EDITING: Modified_positions=2025 {ECO:0000269|PubMed:12907802,
CC ECO:0000269|Ref.1}; Note=Partially edited. Target of Adar.
CC {ECO:0000269|PubMed:12907802};
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family. NaCP60E
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL25396.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=CAA32567.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAA32568.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAA32569.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DQ466888; ABF70206.1; -; mRNA.
DR EMBL; AE013599; AAF47291.6; -; Genomic_DNA.
DR EMBL; AE013599; AGB93705.1; -; Genomic_DNA.
DR EMBL; X14394; CAA32567.1; ALT_SEQ; Genomic_DNA.
DR EMBL; X14395; CAA32568.1; ALT_SEQ; Genomic_DNA.
DR EMBL; X14396; CAA32569.1; ALT_SEQ; Genomic_DNA.
DR EMBL; X14397; CAA32570.1; -; Genomic_DNA.
DR EMBL; X14398; CAA32571.1; -; Genomic_DNA.
DR EMBL; X84409; CAA59129.1; -; Genomic_DNA.
DR EMBL; AY060357; AAL25396.1; ALT_SEQ; mRNA.
DR PIR; S04029; A60165.
DR RefSeq; NP_001189007.2; NM_001202078.3. [Q9W0Y8-1]
DR RefSeq; NP_001261175.1; NM_001274246.2. [Q9W0Y8-3]
DR RefSeq; NP_726495.3; NM_166696.5. [Q9W0Y8-1]
DR SMR; Q9W0Y8; -.
DR BioGRID; 63549; 22.
DR IntAct; Q9W0Y8; 6.
DR STRING; 7227.FBpp0300662; -.
DR TCDB; 1.A.1.10.13; the voltage-gated ion channel (vic) superfamily.
DR GlyGen; Q9W0Y8; 6 sites.
DR PaxDb; Q9W0Y8; -.
DR PRIDE; Q9W0Y8; -.
DR EnsemblMetazoa; FBtr0308342; FBpp0300661; FBgn0085434. [Q9W0Y8-1]
DR EnsemblMetazoa; FBtr0308343; FBpp0300662; FBgn0085434. [Q9W0Y8-1]
DR EnsemblMetazoa; FBtr0333817; FBpp0305951; FBgn0085434. [Q9W0Y8-3]
DR GeneID; 37981; -.
DR KEGG; dme:Dmel_CG34405; -.
DR CTD; 37981; -.
DR FlyBase; FBgn0085434; NaCP60E.
DR VEuPathDB; VectorBase:FBgn0085434; -.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000167926; -.
DR InParanoid; Q9W0Y8; -.
DR OMA; YSWENSK; -.
DR SignaLink; Q9W0Y8; -.
DR BioGRID-ORCS; 37981; 0 hits in 1 CRISPR screen.
DR ChiTaRS; NaCP60E; fly.
DR GenomeRNAi; 37981; -.
DR PRO; PR:Q9W0Y8; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0085434; Expressed in brain and 11 other tissues.
DR ExpressionAtlas; Q9W0Y8; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; ISS:FlyBase.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IBA:GO_Central.
DR GO; GO:0022843; F:voltage-gated cation channel activity; IDA:FlyBase.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; ISS:FlyBase.
DR GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR GO; GO:0042048; P:olfactory behavior; IMP:FlyBase.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR GO; GO:0035725; P:sodium ion transmembrane transport; ISS:FlyBase.
DR GO; GO:0006814; P:sodium ion transport; NAS:FlyBase.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.20.120.350; -; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037; PTHR10037; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00170; NACHANNEL.
DR PROSITE; PS50096; IQ; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Ion channel; Ion transport; Membrane; Olfaction; Reference proteome;
KW Repeat; RNA editing; Sensory transduction; Sodium; Sodium channel;
KW Sodium transport; Transmembrane; Transmembrane helix; Transport;
KW Voltage-gated channel.
FT CHAIN 1..2844
FT /note="Sodium channel protein 60E"
FT /id="PRO_0000291840"
FT TOPO_DOM 1..121
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 122..145
FT /note="Helical; Name=S1 of repeat I"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 146..151
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 152..172
FT /note="Helical; Name=S2 of repeat I"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 173..183
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 184..202
FT /note="Helical; Name=S3 of repeat I"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 203..208
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 209..228
FT /note="Helical; Voltage-sensor; Name=S4 of repeat I"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 229..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 245..265
FT /note="Helical; Name=S5 of repeat I"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 266..340
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT INTRAMEM 341..365
FT /note="Pore-forming"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 366..374
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 375..395
FT /note="Helical; Name=S6 of repeat I"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 396..687
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 688..708
FT /note="Helical; Name=S1 of repeat II"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 709..718
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 719..743
FT /note="Helical; Name=S2 of repeat II"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 744..749
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 750..769
FT /note="Helical; Name=S3 of repeat II"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 770..775
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 776..795
FT /note="Helical; Voltage-sensor; Name=S4 of repeat II"
FT /evidence="ECO:0000250"
FT TOPO_DOM 796..810
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 811..832
FT /note="Helical; Name=S5 of repeat II"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 833..852
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT INTRAMEM 853..873
FT /note="Pore-forming"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 874..889
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 890..910
FT /note="Helical; Name=S6 of repeat II"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 911..1742
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 1743..1763
FT /note="Helical; Name=S1 of repeat III"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 1764..1789
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 1790..1810
FT /note="Helical; Name=S2 of repeat III"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 1811..1813
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 1814..1834
FT /note="Helical; Name=S3 of repeat III"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 1835..1839
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 1840..1861
FT /note="Helical; Voltage-sensor; Name=S4 of repeat III"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 1862..1880
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 1881..1902
FT /note="Helical; Name=S5 of repeat III"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 1903..1943
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT INTRAMEM 1944..1965
FT /note="Pore-forming"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 1966..1981
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 1982..2002
FT /note="Helical; Name=S6 of repeat III"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 2003..2069
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 2070..2090
FT /note="Helical; Name=S1 of repeat IV"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 2091..2095
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 2096..2116
FT /note="Helical; Name=S2 of repeat IV"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 2117..2132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 2133..2153
FT /note="Helical; Name=S3 of repeat IV"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2154..2162
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 2163..2184
FT /note="Helical; Voltage-sensor; Name=S4 of repeat IV"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 2185..2199
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 2200..2220
FT /note="Helical; Name=S5 of repeat IV"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 2221..2236
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT INTRAMEM 2237..2259
FT /note="Pore-forming"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 2260..2288
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 2289..2309
FT /note="Helical; Name=S6 of repeat IV"
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT TOPO_DOM 2310..2844
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REPEAT 107..434
FT /note="I"
FT /evidence="ECO:0000305"
FT REPEAT 668..1130
FT /note="II"
FT /evidence="ECO:0000305"
FT REPEAT 1723..2040
FT /note="III"
FT /evidence="ECO:0000305"
FT REPEAT 2050..2311
FT /note="IV"
FT /evidence="ECO:0000305"
FT DOMAIN 2441..2470
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 452..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1129..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1185..1224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1268..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1577..1630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1635..1654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2457..2479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2584..2668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2780..2802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2818..2844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1185..1204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1272..1287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1608..1628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1636..1654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2584..2637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 282
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 293
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 311
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1778
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1789
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1930
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT DISULFID 272..318
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT DISULFID 875..887
FT /evidence="ECO:0000250|UniProtKB:D0E0C2"
FT VAR_SEQ 2339..2407
FT /note="DPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDI
FT LHALVKHVLGHVEETDN -> VFSSDSRPSRRISPKAARQTIQRTLLTIPSDLLADTIH
FT MPPNLYTSRNCPILLPLSIHHWASRSPIMSL (in isoform P)"
FT /id="VSP_059322"
FT VAR_SEQ 2408..2844
FT /note="Missing (in isoform P)"
FT /id="VSP_059323"
FT VARIANT 2025
FT /note="M -> V (in RNA edited version)"
FT /evidence="ECO:0000269|PubMed:12907802, ECO:0000269|Ref.1"
FT CONFLICT 2
FT /note="S -> G (in Ref. 1; ABF70206)"
FT /evidence="ECO:0000305"
FT CONFLICT 85
FT /note="F -> V (in Ref. 4; CAA32567)"
FT /evidence="ECO:0000305"
FT CONFLICT 93
FT /note="R -> Q (in Ref. 1; ABF70206)"
FT /evidence="ECO:0000305"
FT CONFLICT 195..196
FT /note="SG -> MR (in Ref. 4; CAA32567)"
FT /evidence="ECO:0000305"
FT CONFLICT 253
FT /note="L -> V (in Ref. 4; CAA32567)"
FT /evidence="ECO:0000305"
FT CONFLICT 478
FT /note="G -> S (in Ref. 1; ABF70206)"
FT /evidence="ECO:0000305"
FT CONFLICT 487
FT /note="H -> D (in Ref. 1; ABF70206)"
FT /evidence="ECO:0000305"
FT CONFLICT 535
FT /note="N -> T (in Ref. 1; ABF70206)"
FT /evidence="ECO:0000305"
FT CONFLICT 601
FT /note="Q -> R (in Ref. 1; ABF70206)"
FT /evidence="ECO:0000305"
FT CONFLICT 785
FT /note="V -> A (in Ref. 4; CAA32568)"
FT /evidence="ECO:0000305"
FT CONFLICT 790
FT /note="Q -> K (in Ref. 4; CAA32568)"
FT /evidence="ECO:0000305"
FT CONFLICT 807
FT /note="G -> R (in Ref. 1; ABF70206)"
FT /evidence="ECO:0000305"
FT CONFLICT 813
FT /note="T -> R (in Ref. 4; CAA32568)"
FT /evidence="ECO:0000305"
FT CONFLICT 1052
FT /note="P -> A (in Ref. 1; ABF70206)"
FT /evidence="ECO:0000305"
FT CONFLICT 1114
FT /note="R -> C (in Ref. 1; ABF70206)"
FT /evidence="ECO:0000305"
FT CONFLICT 1125
FT /note="L -> LRL (in Ref. 1; ABF70206)"
FT /evidence="ECO:0000305"
FT CONFLICT 1672
FT /note="Y -> C (in Ref. 1; ABF70206)"
FT /evidence="ECO:0000305"
FT CONFLICT 1736..1737
FT /note="HW -> AL (in Ref. 4; CAA32569)"
FT /evidence="ECO:0000305"
FT CONFLICT 1780
FT /note="T -> A (in Ref. 1; ABF70206)"
FT /evidence="ECO:0000305"
FT CONFLICT 1960
FT /note="M -> N (in Ref. 4; CAA32569)"
FT /evidence="ECO:0000305"
FT CONFLICT 1977
FT /note="Q -> R (in Ref. 4; CAA32569)"
FT /evidence="ECO:0000305"
FT CONFLICT 2015..2016
FT /note="KK -> RR (in Ref. 4; CAA32569)"
FT /evidence="ECO:0000305"
FT CONFLICT 2018
FT /note="Y -> I (in Ref. 4; CAA32570)"
FT /evidence="ECO:0000305"
FT CONFLICT 2133..2134
FT /note="VF -> SV (in Ref. 4; CAA32571)"
FT /evidence="ECO:0000305"
FT CONFLICT 2246
FT /note="R -> Q (in Ref. 4; CAA32571)"
FT /evidence="ECO:0000305"
FT CONFLICT 2261..2263
FT /note="Missing (in Ref. 5; CAA59129)"
FT /evidence="ECO:0000305"
FT CONFLICT 2279
FT /note="C -> S (in Ref. 4; CAA32571)"
FT /evidence="ECO:0000305"
FT CONFLICT 2391..2392
FT /note="LH -> FD (in Ref. 4; CAA32571)"
FT /evidence="ECO:0000305"
FT CONFLICT Q9W0Y8-3:2347
FT /note="S -> N (in Ref. 1; ABF70206)"
FT /evidence="ECO:0000305"
FT CONFLICT Q9W0Y8-3:2400
FT /note="S -> P (in Ref. 1; ABF70206)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2844 AA; 321257 MW; 2D329637EE0C6777 CRC64;
MSDDQATFND EKAVAKHQVV AYTQRSQVKH ENRHIQLVRE YGFHPRTKAS VEDGDVLPRK
FEPFPEHMYG KPLEEIDTFI YEETFCVVSK RFRKNYIHRF TGTKSLFLFY PWSPARRVCV
YIATNQFFDY CVMATILFNC IFLAMTETVE EAEYIFLAIY SIEMVIKIIA KGFLLNKYTY
LRNPWNWLDF VVITSGYATI GMEVGNLAGL RTFRVLRALK TVSIMPGLKT IINALLHSFR
QLAEVMTLTI FCLMVFALFA LQVYMGELRN KCVRQVPTDW TNVSHTDWQI WVNDTDNWLY
DEDELPVLCG NLTGARHCPF EYVCLCVGEN PNHGYTNFDN FMWSMLTTFQ LITLDYWENV
YNMVLATCGP MSVSFFTVVV FFGSFYLINL MLAVVALSYE EEAEITNEER KKDLLDHRDD
STFSFDPSVL NVKKLNKNNK KKIDSRKGVL LASYSKKKTR RKKTKGGKEG GTNGNGNGSN
GDDNKSHSAT PSPGPSPRHS ATERPSALTM QAQKQYQQME QQHKLAKSGS GGSNNPMAPT
PKGRISFQDS GMGVKNPNML YPSDYKGQLI ANSGQPSSNS SGVNRESSQD DSGVVDDHEE
QDTTNDMGHV STVELALSPR EVRLIKCNGN IARIKNHNVY ALHQEFSSEV VVIDDLPDRN
CDRCVHWCTD YESWLQFQNC LYKVVRDPLF ELAITLCIVL NTAFLAMEHH GMSESFRNAL
DVGNKVFTSI FTFECIVKLM ALSKDFFLCG WNIFDLLIVT ASLLDIIFEL VDGLSVLRGL
RLLRVLKLAQ SWTTMKVLLS IIISTIGALG NLTLILVIVI YIFAVIGMQL FSKDYTPEKF
DPDPVPRWNF NDFFHSFMMI FRILCGEWIE PLWDCMRAEE EQGASTCFAI FLPTLVMGNF
MVLNLFLALL LNSFNSEELK SKKEEVGEES KLARSIERVR DLIRKKRQER KDRKERKFAE
KFQQIVLDAQ QAHAQTLSHQ AAVGLERGDK PGVLAETKFH RLSYQESMNR PVSGSDFGFQ
IPLHDGLHTI VDGLEYDDTG DLPEQIQLQA HPLPPTSDSM PPTYESAMMA TTGGSFSSVN
GNGTCQNLTP FVQAERRLQH QISSGVSTQQ YDSREEATYT ESIELLGQYN STDTDPYAND
QRSGCGSFNR GDSLQDNSSR RYGSEEHDEA FLKYQKSLLT RSPSYRKSLD RLSQSSGQSQ
RSLLKSEEAE MRRHSSGQSL NSMSIEQDEL LSQQGNLREE LLNCDQKELF QFLQEEEELQ
KGTKLRRISN VMRSRRPSSQ MGQPENETMV EHSEFDNIIQ SFEKELEEIK RSTTSLERKL
SNLSEPSPAA DEATKAIMEH IAIITGASER SAADEVVLPL NPYDSYDLSS VPRRSQSVSA
AAQRQSVKLK RRSLEKQRKI DEDFSISNEI RKICDQIHAP FVAMEAMAVA ATSASQAQPN
QSPFLRRKVD PFTVQFDRFK RLSLIERVEE VPEEEKPIST LRIESEKMPR KFLHGPDQLR
LDSLSLKSTN SYENLLIQKQ KLGMATPPAV PATPPTSLKS SIEPPTLAQI SSLKTTPPLA
ALTEHQQHFH ATSIQAAPTP AHTHAHSQAH AHSMAGQRRR MEHPQSTLDK AASFQSARTE
SHSSGAADAS SALALAMAQK TEQSQSTAPD ATQKPSAFTR LTEKPWHCLV SYVDDLTVGG
RRNSQGAYND PMTFPSYGAT KAAKVPDDCF PQKCYDHFYF RCPWFMSCMD TQSAKHWTRV
RTAVLTVVDT PAFEWFVLVL IFASSITLCF EDINLDKNKT LKRVLYWINF SFCLIFVVEM
ILKWLALGFS KYFTSFWTIL DFIIVFVSVF SLLIEENENL KVLRSLRTLR ALRPLRAISR
WQGMRIVVNA LMYAIPSIFN VLLVCLVFWL IFSIMGVQFF GGKFFKCVNE MGELLPITEV
NDKWDCIEQN YTWINSKITF DHVGMGYLAL LQVATFEGWM EVMADAVDAR GVDLQPQREA
NLYAYIYFVI FIVCGSFFTL NLFIGVIIDN FNMLKKKYEG GVLEMFLTES QKHYYTAMKK
LGRKKPQKVI KRPINHFLAM FYDLSNSRRF EIAIFVLIFL NMLTMGIEHY DQPHAVFFIL
EVSNAFFTTV FGLEAIVKIV GLRYHYFTVP WNVFDFLLVL ASIFGILMED IMIDLPISPT
LLRVVRVFRI GRILRLIKAA KGIRKLLFAL VVSLPALFNI GALLGLITFI YAILGMSLFG
NVKLQGALDD MVNFQTFGRS MQLLFRLMTS AGWNDVLESL MIQPPDCDPF IHGHTNGNCG
HPLLAITYFT SFIIISYMIV INMYIAIILE NFNQAHQEEE IGIVEDDLEM FYIRWSKYDP
HATQFIHFSQ LSDFIASLDP PLGISKPNNV ALVSFNLPIS KGNKIHCLDI LHALVKHVLG
HVEETDNFKQ LQEQMDVKFK KQFPTRKELE IVSSTRIWKR QEKAAKTIQT GWKEYLRRKR
EKERSNSGDS ATQTSSPGGW QSKLSALNFF HLQVSRRGTA CSSRASSRKS SRASDASDLS
ELAGPWLNLP LMLVSGADEV VKDIKQQNDE LGKRGSIFVE APRASRRRSF YNFFLRHQDA
VDDSLTSPSV HRKTAMNNTT NTTSNSASTS GTASSTATAP ATGCGPAATS ASDSDRHQAV
GGGSAPSRKR ASSFIRKKPP LERGLSAQSA LRVNKNAFVS EASAPEVIVT RPSPEQQTHP
HSLSLRPDNA TLVHVLVHRE SEEYKEEDES SPSVSGNGNG FGVGLDMLSK QPPPQIRITT
GSVESSMDTC AMPTVQIMVD SPKDPPRGDF SSAPIDDVGA PIDVNVQGDT SQVFYDYNPE
KATDDQGNGQ DETAQFESLP DRQR
