SCND1_HUMAN
ID SCND1_HUMAN Reviewed; 179 AA.
AC P57086; Q6IAG7;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=SCAN domain-containing protein 1;
GN Name=SCAND1; Synonyms=SDP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10747874; DOI=10.1074/jbc.m000119200;
RA Schumacher C., Wang H., Honer C., Ding W., Koehn J., Lawrence Q.,
RA Coulis C.M., Wang L.L., Ballinger D., Bowen B.R., Wagner S.;
RT "The SCAN domain mediates selective oligomerization.";
RL J. Biol. Chem. 275:17173-17179(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May regulate transcriptional activity.
CC -!- SUBUNIT: Interacts with ZNF202.
CC -!- INTERACTION:
CC P57086; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-745846, EBI-11522760;
CC P57086; Q96BI3: APH1A; NbExp=3; IntAct=EBI-745846, EBI-2606935;
CC P57086; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-745846, EBI-739580;
CC P57086; Q96ER9: CCDC51; NbExp=3; IntAct=EBI-745846, EBI-11926384;
CC P57086; Q6ZPD8: DGAT2L6; NbExp=3; IntAct=EBI-745846, EBI-12831978;
CC P57086; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-745846, EBI-5916454;
CC P57086; Q9H8Y8: GORASP2; NbExp=6; IntAct=EBI-745846, EBI-739467;
CC P57086; Q6A162: KRT40; NbExp=3; IntAct=EBI-745846, EBI-10171697;
CC P57086; Q969G2: LHX4; NbExp=3; IntAct=EBI-745846, EBI-2865388;
CC P57086; O43674: NDUFB5; NbExp=3; IntAct=EBI-745846, EBI-1246293;
CC P57086; Q96JS3: PGBD1; NbExp=11; IntAct=EBI-745846, EBI-10290053;
CC P57086; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-745846, EBI-79165;
CC P57086; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-745846, EBI-302345;
CC P57086; Q16633: POU2AF1; NbExp=3; IntAct=EBI-745846, EBI-943588;
CC P57086; O15258: RER1; NbExp=3; IntAct=EBI-745846, EBI-716910;
CC P57086; Q9NXI6: RNF186; NbExp=3; IntAct=EBI-745846, EBI-2129361;
CC P57086; Q9NS64: RPRM; NbExp=3; IntAct=EBI-745846, EBI-1052363;
CC P57086; Q8WV19: SFT2D1; NbExp=3; IntAct=EBI-745846, EBI-2854842;
CC P57086; Q8N114-3: SHISA5; NbExp=3; IntAct=EBI-745846, EBI-13369834;
CC P57086; Q9BYT1: SLC17A9; NbExp=3; IntAct=EBI-745846, EBI-3940816;
CC P57086; Q6UWW9: TMEM207; NbExp=3; IntAct=EBI-745846, EBI-13301303;
CC P57086; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-745846, EBI-11528917;
CC P57086; Q3KNT9: TMEM95; NbExp=3; IntAct=EBI-745846, EBI-12892569;
CC P57086; Q15654: TRIP6; NbExp=3; IntAct=EBI-745846, EBI-742327;
CC P57086; A6NH52: TVP23A; NbExp=3; IntAct=EBI-745846, EBI-13296313;
CC P57086; Q9BRR0: ZKSCAN3; NbExp=3; IntAct=EBI-745846, EBI-1965777;
CC P57086; Q969J2: ZKSCAN4; NbExp=7; IntAct=EBI-745846, EBI-2818641;
CC P57086; Q9P0L1: ZKSCAN7; NbExp=4; IntAct=EBI-745846, EBI-743851;
CC P57086; Q9P0L1-2: ZKSCAN7; NbExp=6; IntAct=EBI-745846, EBI-10698225;
CC P57086; P49910: ZNF165; NbExp=11; IntAct=EBI-745846, EBI-741694;
CC P57086; Q15697-2: ZNF174; NbExp=3; IntAct=EBI-745846, EBI-11158827;
CC P57086; O14771: ZNF213; NbExp=3; IntAct=EBI-745846, EBI-12838388;
CC P57086; P17028: ZNF24; NbExp=7; IntAct=EBI-745846, EBI-707773;
CC P57086; O14978: ZNF263; NbExp=5; IntAct=EBI-745846, EBI-744493;
CC P57086; Q53GI3: ZNF394; NbExp=11; IntAct=EBI-745846, EBI-10211248;
CC P57086; Q96N95-3: ZNF396; NbExp=6; IntAct=EBI-745846, EBI-12328453;
CC P57086; Q8NF99-2: ZNF397; NbExp=4; IntAct=EBI-745846, EBI-11524467;
CC P57086; Q9NWS9-2: ZNF446; NbExp=5; IntAct=EBI-745846, EBI-740232;
CC P57086; Q6P9G9: ZNF449; NbExp=8; IntAct=EBI-745846, EBI-10215956;
CC P57086; Q6P088: ZNF483; NbExp=3; IntAct=EBI-745846, EBI-10196963;
CC P57086; Q96IT1: ZNF496; NbExp=3; IntAct=EBI-745846, EBI-743906;
CC P57086; O43309: ZSCAN12; NbExp=5; IntAct=EBI-745846, EBI-1210440;
CC P57086; Q9H4T2: ZSCAN16; NbExp=3; IntAct=EBI-745846, EBI-723596;
CC P57086; Q8TBC5: ZSCAN18; NbExp=3; IntAct=EBI-745846, EBI-3919096;
CC P57086; P10073: ZSCAN22; NbExp=6; IntAct=EBI-745846, EBI-10178224;
CC P57086; Q3MJ62: ZSCAN23; NbExp=8; IntAct=EBI-745846, EBI-5667532;
CC P57086; Q6NSZ9-2: ZSCAN25; NbExp=3; IntAct=EBI-745846, EBI-14650477;
CC P57086; Q9NX65: ZSCAN32; NbExp=3; IntAct=EBI-745846, EBI-739949;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF204271; AAF59839.1; -; mRNA.
DR EMBL; CR457188; CAG33469.1; -; mRNA.
DR EMBL; AL109965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW76150.1; -; Genomic_DNA.
DR EMBL; BC000785; AAH00785.1; -; mRNA.
DR EMBL; BC036709; AAH36709.1; -; mRNA.
DR EMBL; BC041022; AAH41022.1; -; mRNA.
DR CCDS; CCDS13269.1; -.
DR RefSeq; NP_057642.1; NM_016558.3.
DR RefSeq; NP_361012.2; NM_033630.2.
DR AlphaFoldDB; P57086; -.
DR SMR; P57086; -.
DR BioGRID; 119434; 114.
DR IntAct; P57086; 57.
DR MINT; P57086; -.
DR STRING; 9606.ENSP00000363103; -.
DR MoonDB; P57086; Predicted.
DR iPTMnet; P57086; -.
DR PhosphoSitePlus; P57086; -.
DR BioMuta; SCAND1; -.
DR DMDM; 10720272; -.
DR EPD; P57086; -.
DR jPOST; P57086; -.
DR MassIVE; P57086; -.
DR MaxQB; P57086; -.
DR PaxDb; P57086; -.
DR PeptideAtlas; P57086; -.
DR PRIDE; P57086; -.
DR ProteomicsDB; 56995; -.
DR Antibodypedia; 11616; 231 antibodies from 28 providers.
DR DNASU; 51282; -.
DR Ensembl; ENST00000305978.7; ENSP00000301995.2; ENSG00000171222.11.
DR Ensembl; ENST00000373991.3; ENSP00000363103.3; ENSG00000171222.11.
DR Ensembl; ENST00000615116.1; ENSP00000481289.1; ENSG00000171222.11.
DR GeneID; 51282; -.
DR KEGG; hsa:51282; -.
DR MANE-Select; ENST00000305978.7; ENSP00000301995.2; NM_033630.3; NP_361012.3.
DR UCSC; uc002xen.3; human.
DR CTD; 51282; -.
DR DisGeNET; 51282; -.
DR GeneCards; SCAND1; -.
DR HGNC; HGNC:10566; SCAND1.
DR HPA; ENSG00000171222; Low tissue specificity.
DR MIM; 610416; gene.
DR neXtProt; NX_P57086; -.
DR OpenTargets; ENSG00000171222; -.
DR PharmGKB; PA34979; -.
DR VEuPathDB; HostDB:ENSG00000171222; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163024; -.
DR HOGENOM; CLU_107409_0_0_1; -.
DR InParanoid; P57086; -.
DR OMA; QALRWCR; -.
DR PhylomeDB; P57086; -.
DR PathwayCommons; P57086; -.
DR SignaLink; P57086; -.
DR SIGNOR; P57086; -.
DR BioGRID-ORCS; 51282; 33 hits in 1079 CRISPR screens.
DR ChiTaRS; SCAND1; human.
DR GeneWiki; SCAND1; -.
DR GenomeRNAi; 51282; -.
DR Pharos; P57086; Tbio.
DR PRO; PR:P57086; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; P57086; protein.
DR Bgee; ENSG00000171222; Expressed in mucosa of transverse colon and 189 other tissues.
DR Genevisible; P57086; HS.
DR GO; GO:0005634; C:nucleus; IDA:LIFEdb.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR Pfam; PF02023; SCAN; 1.
DR SMART; SM00431; SCAN; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..179
FT /note="SCAN domain-containing protein 1"
FT /id="PRO_0000097632"
FT DOMAIN 108..166
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..57
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 179 AA; 19082 MW; 88AFEFC8E4DC9796 CRC64;
MAATEPILAA TGSPAAVPPE KLEGAGSSSA PERNCVGSSL PEASPPAPEP SSPNAAVPEA
IPTPRAAASA ALELPLGPAP VSVAPQAEAE ARSTPGPAGS RLGPETFRQR FRQFRYQDAA
GPREAFRQLR ELSRQWLRPD IRTKEQIVEM LVQEQLLAIL PEAARARRIR RRTDVRITG
