SCND2_HUMAN
ID SCND2_HUMAN Reviewed; 306 AA.
AC Q9GZW5; A8K374; Q9H9G1;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 11-APR-2003, sequence version 2.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Putative SCAN domain-containing protein SCAND2P;
DE AltName: Full=SCAN domain-containing protein 2 pseudogene;
GN Name=SCAND2P; Synonyms=SCAND2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
RX PubMed=11056053; DOI=10.1006/geno.2000.6343;
RA Dupuy D., Aubert I., Duperat V.G., Petit J., Taine L., Stef M., Bloch B.,
RA Arveiler B.;
RT "Mapping, characterization, and expression analysis of the SM-20 human
RT homologue, C1orf12, and identification of a novel related gene, SCAND2.";
RL Genomics 69:348-354(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Fetal brain, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Kidney, Testis, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9GZW5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9GZW5-2; Sequence=VSP_007110, VSP_007111;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AF229246; AAG33966.1; -; mRNA.
DR EMBL; AF244812; AAG34567.1; -; Genomic_DNA.
DR EMBL; AK022844; BAB14268.1; -; mRNA.
DR EMBL; AK290489; BAF83178.1; -; mRNA.
DR EMBL; BC011547; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC012929; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC063836; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q9GZW5; -.
DR SMR; Q9GZW5; -.
DR iPTMnet; Q9GZW5; -.
DR PhosphoSitePlus; Q9GZW5; -.
DR BioMuta; HGNC:10567; -.
DR DMDM; 29839632; -.
DR MassIVE; Q9GZW5; -.
DR PeptideAtlas; Q9GZW5; -.
DR PRIDE; Q9GZW5; -.
DR GeneCards; SCAND2P; -.
DR HGNC; HGNC:10567; SCAND2P.
DR MIM; 610417; gene.
DR neXtProt; NX_Q9GZW5; -.
DR InParanoid; Q9GZW5; -.
DR PhylomeDB; Q9GZW5; -.
DR PathwayCommons; Q9GZW5; -.
DR ChiTaRS; SCAND2P; human.
DR Pharos; Q9GZW5; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q9GZW5; protein.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR Pfam; PF02023; SCAN; 1.
DR SMART; SM00431; SCAN; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
PE 5: Uncertain;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..306
FT /note="Putative SCAN domain-containing protein SCAND2P"
FT /id="PRO_0000097633"
FT DOMAIN 45..129
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT REGION 123..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 135..152
FT /note="RARPSGRTPPAQLRSPWP -> CLMWLWEFLQRRAGVARR (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_007110"
FT VAR_SEQ 153..306
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_007111"
FT VARIANT 110
FT /note="P -> T (in dbSNP:rs16974462)"
FT /id="VAR_034421"
FT VARIANT 185
FT /note="A -> T (in dbSNP:rs698620)"
FT /id="VAR_021961"
FT CONFLICT 6
FT /note="D -> V (in Ref. 2; BAF83178)"
FT /evidence="ECO:0000305"
FT CONFLICT 94
FT /note="P -> R (in Ref. 1; AAG34567/AAG33966)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 306 AA; 34217 MW; D5E11136D30983EB CRC64;
MAVAVDQQIQ TPSVQDLQIV KLEEDSHWEQ EISLQGNYPG PETSCQSFWH FRYQEASRPR
EALLQLQKLC CQWLRPEKCT KEQILELLVL EQFPTVLLQE IQIWVRQQHP ESGEEAVALV
EDLQKEPGRQ RLEPRARPSG RTPPAQLRSP WPMTAAGPAS RARASETGST ASCAGRWRTC
CAAAAAPSAA RSASARTGRS TSSCARAARA PSATEGALTR TPAPRRPLQR RRPGTGPWRP
GRQRGAGTAP PGTQPRQRPS PRPTPRRPRP RLARPRAGQK PWLLVIRSME RVMYVMLIIQ
METEDV
