SCND3_HUMAN
ID SCND3_HUMAN Reviewed; 1325 AA.
AC Q6R2W3; Q2NKL9; Q5SRJ3; Q8TCN2; Q96MV9; Q96PW3;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=SCAN domain-containing protein 3;
DE AltName: Full=Transposon-derived Buster4 transposase-like protein;
DE AltName: Full=Zinc finger BED domain-containing protein 9;
GN Name=ZBED9; Synonyms=Buster4, KIAA1925, SCAND3, ZNF305P2, ZNF452;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Zhou G., Liu X., Yu L.;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LYS-465.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-782.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 179-1325.
RC TISSUE=Brain;
RX PubMed=11572484; DOI=10.1093/dnares/8.4.179;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXI. The
RT complete sequences of 60 new cDNA clones from brain which code for large
RT proteins.";
RL DNA Res. 8:179-187(2001).
RN [7]
RP PHYLOGENY, AND GENE NOMENCLATURE.
RX PubMed=23533661; DOI=10.1371/journal.pone.0059940;
RA Hayward A., Ghazal A., Andersson G., Andersson L., Jern P.;
RT "ZBED evolution: repeated utilization of DNA transposons as regulators of
RT diverse host functions.";
RL PLoS ONE 8:E59940-E59940(2013).
RN [8]
RP TISSUE SPECIFICITY.
RX PubMed=28418919; DOI=10.18632/oncotarget.16408;
RA Zhang X., Zhou H., Zhang Y., Cai L., Jiang G., Li A., Miao Y., Li Q.,
RA Qiu X., Wang E.;
RT "ZNF452 facilitates tumor proliferation and invasion via activating AKT-
RT GSK3beta signaling pathway and predicts poor prognosis of non-small cell
RT lung cancer patients.";
RL Oncotarget 8:38863-38875(2017).
CC -!- INTERACTION:
CC Q6R2W3; O00629: KPNA4; NbExp=2; IntAct=EBI-21631759, EBI-396343;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC -!- TISSUE SPECIFICITY: Weakly expressed in the lung (at protein level).
CC {ECO:0000269|PubMed:28418919}.
CC -!- MISCELLANEOUS: Highly expressed in non-small-cell lung carcinoma
CC (NSCLC) tissue, with increased expression correlating with advanced
CC disease, lymph node metastases and poor prognosis, as such may be a
CC candidate prognostic marker (PubMed:28418919). May act as an oncogene
CC and promote tumor growth via positive regulation of cell cycle
CC progression at G1/S phase transition (PubMed:28418919). May promote
CC invasion and metastasis via activation of the AKT/GSK-3 beta signaling
CC pathway (PubMed:28418919). Expressed in the cytoplasm in NSCLC tissue
CC (PubMed:28418919). {ECO:0000269|PubMed:28418919}.
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DR EMBL; AL713690; CAD28490.2; -; mRNA.
DR EMBL; BX647791; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AY517631; AAS01734.1; -; mRNA.
DR EMBL; AL671879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC110834; AAI10835.1; -; mRNA.
DR EMBL; BC111741; AAI11742.1; -; mRNA.
DR EMBL; BC111742; AAI11743.1; -; mRNA.
DR EMBL; AK056369; BAB71166.1; -; mRNA.
DR EMBL; AB067512; BAB67818.1; -; mRNA.
DR CCDS; CCDS34355.1; -.
DR RefSeq; NP_001316545.1; NM_001329616.1.
DR RefSeq; NP_443155.1; NM_052923.1.
DR AlphaFoldDB; Q6R2W3; -.
DR BioGRID; 125371; 11.
DR IntAct; Q6R2W3; 8.
DR STRING; 9606.ENSP00000395259; -.
DR GlyConnect; 2072; 1 N-Linked glycan (1 site).
DR GlyGen; Q6R2W3; 2 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site).
DR iPTMnet; Q6R2W3; -.
DR PhosphoSitePlus; Q6R2W3; -.
DR BioMuta; ZBED9; -.
DR DMDM; 74710067; -.
DR EPD; Q6R2W3; -.
DR MassIVE; Q6R2W3; -.
DR PaxDb; Q6R2W3; -.
DR PeptideAtlas; Q6R2W3; -.
DR PRIDE; Q6R2W3; -.
DR ProteomicsDB; 67309; -.
DR Antibodypedia; 25911; 82 antibodies from 18 providers.
DR DNASU; 114821; -.
DR Ensembl; ENST00000452236.3; ENSP00000395259.2; ENSG00000232040.4.
DR GeneID; 114821; -.
DR KEGG; hsa:114821; -.
DR MANE-Select; ENST00000452236.3; ENSP00000395259.2; NM_052923.2; NP_443155.1.
DR UCSC; uc003nlo.3; human.
DR CTD; 114821; -.
DR DisGeNET; 114821; -.
DR GeneCards; ZBED9; -.
DR HGNC; HGNC:13851; ZBED9.
DR HPA; ENSG00000232040; Tissue enhanced (testis).
DR MIM; 615254; gene.
DR neXtProt; NX_Q6R2W3; -.
DR OpenTargets; ENSG00000232040; -.
DR PharmGKB; PA162402460; -.
DR VEuPathDB; HostDB:ENSG00000232040; -.
DR eggNOG; KOG0017; Eukaryota.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160807; -.
DR HOGENOM; CLU_006012_0_0_1; -.
DR InParanoid; Q6R2W3; -.
DR OMA; VWSQLFK; -.
DR OrthoDB; 51918at2759; -.
DR PhylomeDB; Q6R2W3; -.
DR TreeFam; TF323092; -.
DR PathwayCommons; Q6R2W3; -.
DR SignaLink; Q6R2W3; -.
DR BioGRID-ORCS; 114821; 7 hits in 1076 CRISPR screens.
DR ChiTaRS; ZBED9; human.
DR GeneWiki; ZNF452; -.
DR GenomeRNAi; 114821; -.
DR Pharos; Q6R2W3; Tdark.
DR PRO; PR:Q6R2W3; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q6R2W3; protein.
DR Bgee; ENSG00000232040; Expressed in left testis and 115 other tissues.
DR ExpressionAtlas; Q6R2W3; baseline and differential.
DR Genevisible; Q6R2W3; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0045787; P:positive regulation of cell cycle; IMP:UniProtKB.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:UniProtKB.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR Pfam; PF02023; SCAN; 1.
DR SMART; SM00431; SCAN; 1.
DR SUPFAM; SSF53098; SSF53098; 2.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Nucleus; Reference proteome.
FT CHAIN 1..1325
FT /note="SCAN domain-containing protein 3"
FT /id="PRO_0000245846"
FT DOMAIN 52..134
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT DOMAIN 366..526
FT /note="Integrase catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
FT COILED 246..275
FT /evidence="ECO:0000255"
FT COILED 542..568
FT /evidence="ECO:0000255"
FT VARIANT 155
FT /note="M -> V (in dbSNP:rs409029)"
FT /id="VAR_027012"
FT VARIANT 465
FT /note="Q -> K (in dbSNP:rs41270593)"
FT /evidence="ECO:0000269|PubMed:14574404"
FT /id="VAR_061703"
FT CONFLICT 145
FT /note="T -> A (in Ref. 1; BX647791)"
FT /evidence="ECO:0000305"
FT CONFLICT 536
FT /note="L -> P (in Ref. 1; BX647791)"
FT /evidence="ECO:0000305"
FT CONFLICT 582
FT /note="L -> P (in Ref. 1; BX647791)"
FT /evidence="ECO:0000305"
FT CONFLICT 913
FT /note="I -> V (in Ref. 1; BX647791)"
FT /evidence="ECO:0000305"
FT CONFLICT 1112
FT /note="F -> FF (in Ref. 1; CAD28490)"
FT /evidence="ECO:0000305"
FT CONFLICT 1169
FT /note="L -> H (in Ref. 1; BX647791)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1325 AA; 151666 MW; 637F5B2A42929A01 CRC64;
MEAVSRVFPA LAGQAPEEQG EIIKVKVKEE DHTWDQESAL RRNLSYTREL SRQRFRQFCY
QETPGPREAL SQLRELCRQW LNPEIHTKEQ ILELLVLEQF LTILPEELQS WVREHNPESG
EEVVTLLEDL ERELDEPRQQ VSQGTYGQEV SMEEMIPLDS AKESLGTQLQ SMEDRMECES
PEPHPLQDNG SFLWFSMMSQ SMGGDNLSSL DTNEAEIEPE NMREKFFRSL ARLLENKSNN
TKIFSKAKYC QLIKEVKEAK AKAKKESVDY RRLARFDVIL VQGNEKLIEA VNGETDKIRY
YLHSEDLFDI LHNTHLSIGH GGRTRMEKEL QAKYKNITKE VIMLYLTLCK PCQQKNSKLK
KVLTSKSIKE VSSRCQVDLI DMQLNPDGEY RFILHYQDLC TKLTFLRSLK SKRPTEVAHA
LLDIFTIIGA PSVLQSDNGR EFSSQVVSEL SNIWPELKIV HGKSQTCQSQ SSAEQTEDIR
KRIFSWMQTN NSSHWTEFLW FIQMSQNQPY HRSMQQTPCE SAFSSEAKLG LSHSQLTEEL
VASLHTENEL DQADKELENT LRAQYEENIE TGTDSSDIEE NLSVTPKVAE KSPPESRLRF
LSCVVCEKEC TGVNSCISCD GNIHAICGVP SQHGTEGCGR QITCSLCYET STMKRKHDEI
QRSLPVKPSK MLKPSGTPFS PDKVGDWMAK QASLDFFVKK RHAFSEHSSS NKRNVNNRSY
PEEGKTKRVH ASFTRKYDPS YIEFGFVAVI DGEVLKPQCI ICGDVLANEA MKPSKLKRHL
YSKHKEISSQ PKEFFERKSS ELKSQPKQVF NVSHINISAL RASYKVALPV AKSKTPYTIA
ETLVKDCIKE VCLEMLGESA AKKVAQVPLS NDTIARRIQE LANDMEDQLI EQIKLAKYFS
LQLDECRDIA NMIILLVYVR FEHDDDIKEE FFFSASLPTN TTSSELYEAV KNYIVNKCGL
EFKFCVGVCS DGAASMTGKH SEVVTQIKEL APECKTTHCF IHRESLAMKK ISAELNSVLN
DIVKIVNYIK SNSLNSRLFS LLCDNMEADH KQLLLHAEIR WLSRGKVLSR MFEIRNELLV
FLQGKKPMWS QLFKDVNWTA RLAYLSDIFS IFNDLNASMQ GKNATYFSMA DKVEGQKQKL
EAWKNRISTD CYDMFHNLTT IINEVGNDLD IAHLRKVISE HLTNLLECFE FYFPSKEDPR
IGNLWIQNPF LSSKDNLNLT VTLQDKLLKL ATDEGLKISF ENTASLPSFW IKAKNDYPEL
AEIALKLLLL FPSTYLCETG FSTLSVIKTK HRNSLNIHYP LRVALSSIQP RLDKLTSKKQ
AHLSH
