ID   SCNM1_BOVIN             Reviewed;         230 AA.
AC   Q3ZBR0;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Sodium channel modifier 1;
GN   Name=SCNM1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in alternative splicing of pre-mRNAs, possibly
CC       by contributing to the selection of non-consensus donor sites.
CC       {ECO:0000250|UniProtKB:Q8K136}.
CC   -!- SUBUNIT: Interacts with spliceosomal Sm proteins (By similarity).
CC       Interacts with LUC7L2 and SNRNP70, which suggests a role as a
CC       spliceosome component (By similarity). {ECO:0000250|UniProtKB:Q8K136,
CC       ECO:0000250|UniProtKB:Q9BWG6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q8K136}. Nucleus speckle
CC       {ECO:0000250|UniProtKB:Q8K136}. Note=Colocalizes with LUC7L2 and
CC       SNRNP70 in nuclear speckles. {ECO:0000250|UniProtKB:Q8K136}.
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DR   EMBL; BC103163; AAI03164.1; -; mRNA.
DR   RefSeq; NP_001029426.1; NM_001034254.2.
DR   AlphaFoldDB; Q3ZBR0; -.
DR   SMR; Q3ZBR0; -.
DR   STRING; 9913.ENSBTAP00000024057; -.
DR   PaxDb; Q3ZBR0; -.
DR   Ensembl; ENSBTAT00000024057; ENSBTAP00000024057; ENSBTAG00000018070.
DR   GeneID; 505644; -.
DR   KEGG; bta:505644; -.
DR   CTD; 79005; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018070; -.
DR   VGNC; VGNC:55678; SCNM1.
DR   eggNOG; ENOG502QWNV; Eukaryota.
DR   GeneTree; ENSGT00390000010811; -.
DR   HOGENOM; CLU_059812_0_0_1; -.
DR   InParanoid; Q3ZBR0; -.
DR   OMA; MLTVHRQ; -.
DR   OrthoDB; 1557322at2759; -.
DR   TreeFam; TF332168; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000018070; Expressed in oocyte and 104 other tissues.
DR   GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000380; P:alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; IBA:GO_Central.
DR   InterPro; IPR033570; SCNM1.
DR   InterPro; IPR031625; SCNM1_acidic.
DR   InterPro; IPR031622; Znf-SCNM1.
DR   PANTHER; PTHR32297; PTHR32297; 1.
DR   Pfam; PF15805; SCNM1_acidic; 1.
DR   Pfam; PF15803; zf-SCNM1; 1.
PE   2: Evidence at transcript level;
KW   Isopeptide bond; Metal-binding; mRNA processing; mRNA splicing; Nucleus;
KW   Phosphoprotein; Reference proteome; Ubl conjugation; Zinc; Zinc-finger.
FT   CHAIN           1..230
FT                   /note="Sodium channel modifier 1"
FT                   /id="PRO_0000259634"
FT   ZN_FING         42..74
FT                   /note="Matrin-type"
FT   REGION          76..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..230
FT                   /note="Required for interaction with LUC7L2"
FT                   /evidence="ECO:0000250"
FT   MOTIF           4..20
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        138..152
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BWG6"
FT   MOD_RES         183
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K136"
FT   MOD_RES         219
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BWG6"
FT   CROSSLNK        67
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BWG6"
SQ   SEQUENCE   230 AA;  25999 MW;  64F4887381160328 CRC64;
     MSFKREGDDW SQLNVLKKRR VGDLLASYIP EDEALMLRDG RFACAICPHR PVLDTLAMLT
     AHRAGKKHLS SLQLFYGKKP PGKGTEQNPR QHNELRREET TAEAPLLTQT RLITQSALHR
     APHYNSCCRR KYRPEAPRPS VSRPPLPPPE VEPQGGKISR EPEPEAGSQT KESATVSSPA
     PMSPTRRRAL DHYLTLRSSG WIPDGRGRWI KDENVEFDSD EEEPPDLPLD