ID   SCNM1_DANRE             Reviewed;         249 AA.
AC   Q2YDS5; Q5BJD3; Q6TGU4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Sodium channel modifier 1;
GN   Name=scnm1; ORFNames=zgc:123015;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in alternative splicing of pre-mRNAs, possibly
CC       by contributing to the selection of non-consensus donor sites.
CC       {ECO:0000250|UniProtKB:Q8K136}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q8K136}. Nucleus speckle
CC       {ECO:0000250|UniProtKB:Q8K136}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q2YDS5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q2YDS5-2; Sequence=VSP_021492;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH91527.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AY398412; AAQ97845.1; -; mRNA.
DR   EMBL; BC091527; AAH91527.1; ALT_INIT; mRNA.
DR   EMBL; BC110091; AAI10092.1; -; mRNA.
DR   RefSeq; NP_001001813.1; NM_001001813.1. [Q2YDS5-2]
DR   RefSeq; XP_005158218.1; XM_005158161.3. [Q2YDS5-1]
DR   AlphaFoldDB; Q2YDS5; -.
DR   SMR; Q2YDS5; -.
DR   STRING; 7955.ENSDARP00000026288; -.
DR   PaxDb; Q2YDS5; -.
DR   Ensembl; ENSDART00000004284; ENSDARP00000026288; ENSDARG00000003027. [Q2YDS5-1]
DR   Ensembl; ENSDART00000132351; ENSDARP00000118829; ENSDARG00000003027. [Q2YDS5-2]
DR   GeneID; 321696; -.
DR   KEGG; dre:321696; -.
DR   CTD; 79005; -.
DR   ZFIN; ZDB-GENE-030131-415; scnm1.
DR   eggNOG; ENOG502QWNV; Eukaryota.
DR   GeneTree; ENSGT00390000010811; -.
DR   HOGENOM; CLU_059812_0_0_1; -.
DR   InParanoid; Q2YDS5; -.
DR   OMA; MLTVHRQ; -.
DR   OrthoDB; 1557322at2759; -.
DR   PhylomeDB; Q2YDS5; -.
DR   TreeFam; TF332168; -.
DR   PRO; PR:Q2YDS5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   Bgee; ENSDARG00000003027; Expressed in blastula and 28 other tissues.
DR   GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000380; P:alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; IBA:GO_Central.
DR   InterPro; IPR033570; SCNM1.
DR   InterPro; IPR031625; SCNM1_acidic.
DR   InterPro; IPR031622; Znf-SCNM1.
DR   PANTHER; PTHR32297; PTHR32297; 1.
DR   Pfam; PF15805; SCNM1_acidic; 1.
DR   Pfam; PF15803; zf-SCNM1; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Metal-binding; mRNA processing; mRNA splicing;
KW   Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..249
FT                   /note="Sodium channel modifier 1"
FT                   /id="PRO_0000259637"
FT   ZN_FING         42..74
FT                   /note="Matrin-type"
FT   REGION          94..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          128..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           4..20
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        131..153
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         41..42
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15520368"
FT                   /id="VSP_021492"
FT   CONFLICT        153
FT                   /note="S -> F (in Ref. 2; AAH91527)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        188
FT                   /note="T -> S (in Ref. 2; AAH91527)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        219
FT                   /note="D -> E (in Ref. 2; AAH91527)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   249 AA;  28752 MW;  CDE33D4C36FB2D7A CRC64;
     MSFKREGDDQ SQLNILKKRR VSDLLSNFIP DDEATLMKNG RYSCLVCSHR PVFDTVDMLV
     VHRKGKRHLE GMKWFYGKKN QLRREIDKRR HQDYVKAEDD RQEPSSSAPL LTQTRKITHH
     ALLRTVPYSS CHKKASERSE SSSKEHRNDL ANSHLSMRTE SNDSRTTVHQ GPSEVKGEAK
     KKKKGASTLS SSVCEPLTEQ RRRELDHYLK LKSSGWLQDR SGKWVKDENV EFDSDEEEPT
     LLPPCSESS