SCNM1_HUMAN
ID SCNM1_HUMAN Reviewed; 230 AA.
AC Q9BWG6; B4DWR1; Q5JR74;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Sodium channel modifier 1;
GN Name=SCNM1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Esophagus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH SPLICEOSOMAL SM PROTEINS.
RX PubMed=17656373; DOI=10.1093/hmg/ddm206;
RA Howell V.M., Jones J.M., Bergren S.K., Li L., Billi A.C., Avenarius M.R.,
RA Meisler M.H.;
RT "Evidence for a direct role of the disease modifier SCNM1 in splicing.";
RL Hum. Mol. Genet. 16:2506-2516(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [10]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-67, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: Plays a role in alternative splicing of pre-mRNAs, possibly
CC by contributing to the selection of non-consensus donor sites.
CC {ECO:0000250|UniProtKB:Q8K136}.
CC -!- SUBUNIT: Interacts with spliceosomal Sm proteins (PubMed:17656373).
CC Interacts with LUC7L2 and SNRNP70, which suggests a role as a
CC spliceosome component (By similarity). {ECO:0000250|UniProtKB:Q8K136,
CC ECO:0000269|PubMed:17656373}.
CC -!- INTERACTION:
CC Q9BWG6; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-748391, EBI-10173507;
CC Q9BWG6; Q6PJH3: AKAP9; NbExp=3; IntAct=EBI-748391, EBI-11745576;
CC Q9BWG6; Q5T686: AVPI1; NbExp=3; IntAct=EBI-748391, EBI-8640233;
CC Q9BWG6; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-748391, EBI-4400025;
CC Q9BWG6; Q9BYV9: BACH2; NbExp=3; IntAct=EBI-748391, EBI-1642333;
CC Q9BWG6; Q8N7W2-2: BEND7; NbExp=3; IntAct=EBI-748391, EBI-10181188;
CC Q9BWG6; Q6PI77: BHLHB9; NbExp=3; IntAct=EBI-748391, EBI-11519926;
CC Q9BWG6; Q9H2G9: BLZF1; NbExp=6; IntAct=EBI-748391, EBI-2548012;
CC Q9BWG6; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-748391, EBI-739580;
CC Q9BWG6; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-748391, EBI-3866279;
CC Q9BWG6; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-748391, EBI-11530605;
CC Q9BWG6; Q8NA61: CBY2; NbExp=3; IntAct=EBI-748391, EBI-741724;
CC Q9BWG6; Q8NA61-2: CBY2; NbExp=5; IntAct=EBI-748391, EBI-11524851;
CC Q9BWG6; Q9BUN5-3: CCDC28B; NbExp=3; IntAct=EBI-748391, EBI-12920646;
CC Q9BWG6; Q96LY2-2: CCDC74B; NbExp=3; IntAct=EBI-748391, EBI-17967022;
CC Q9BWG6; Q01850: CDR2; NbExp=6; IntAct=EBI-748391, EBI-1181367;
CC Q9BWG6; Q86X02: CDR2L; NbExp=3; IntAct=EBI-748391, EBI-11063830;
CC Q9BWG6; Q9C0F1: CEP44; NbExp=3; IntAct=EBI-748391, EBI-744115;
CC Q9BWG6; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-748391, EBI-739624;
CC Q9BWG6; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-748391, EBI-742887;
CC Q9BWG6; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-748391, EBI-741528;
CC Q9BWG6; Q96Q77: CIB3; NbExp=6; IntAct=EBI-748391, EBI-10292696;
CC Q9BWG6; Q9Y2V7: COG6; NbExp=5; IntAct=EBI-748391, EBI-3866319;
CC Q9BWG6; Q9GZU7: CTDSP1; NbExp=3; IntAct=EBI-748391, EBI-751587;
CC Q9BWG6; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-748391, EBI-3867333;
CC Q9BWG6; O60759: CYTIP; NbExp=3; IntAct=EBI-748391, EBI-997814;
CC Q9BWG6; Q86X51: EZHIP; NbExp=3; IntAct=EBI-748391, EBI-12827735;
CC Q9BWG6; Q3B820: FAM161A; NbExp=3; IntAct=EBI-748391, EBI-719941;
CC Q9BWG6; Q86W67: FAM228A; NbExp=3; IntAct=EBI-748391, EBI-12958227;
CC Q9BWG6; Q9NW38: FANCL; NbExp=3; IntAct=EBI-748391, EBI-2339898;
CC Q9BWG6; Q14192: FHL2; NbExp=3; IntAct=EBI-748391, EBI-701903;
CC Q9BWG6; Q5TD97: FHL5; NbExp=6; IntAct=EBI-748391, EBI-750641;
CC Q9BWG6; Q9BVV2: FNDC11; NbExp=3; IntAct=EBI-748391, EBI-744935;
CC Q9BWG6; O43559: FRS3; NbExp=3; IntAct=EBI-748391, EBI-725515;
CC Q9BWG6; A1L4K1: FSD2; NbExp=3; IntAct=EBI-748391, EBI-5661036;
CC Q9BWG6; O95995: GAS8; NbExp=3; IntAct=EBI-748391, EBI-1052570;
CC Q9BWG6; O75420: GIGYF1; NbExp=3; IntAct=EBI-748391, EBI-947774;
CC Q9BWG6; Q08379: GOLGA2; NbExp=5; IntAct=EBI-748391, EBI-618309;
CC Q9BWG6; A6NEM1: GOLGA6L9; NbExp=5; IntAct=EBI-748391, EBI-5916454;
CC Q9BWG6; P54257: HAP1; NbExp=3; IntAct=EBI-748391, EBI-712814;
CC Q9BWG6; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-748391, EBI-2549423;
CC Q9BWG6; Q9NP66: HMG20A; NbExp=7; IntAct=EBI-748391, EBI-740641;
CC Q9BWG6; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-748391, EBI-748420;
CC Q9BWG6; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-748391, EBI-10961706;
CC Q9BWG6; O75031: HSF2BP; NbExp=3; IntAct=EBI-748391, EBI-7116203;
CC Q9BWG6; Q13422: IKZF1; NbExp=3; IntAct=EBI-748391, EBI-745305;
CC Q9BWG6; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-748391, EBI-11522367;
CC Q9BWG6; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-748391, EBI-747204;
CC Q9BWG6; Q0VD86: INCA1; NbExp=4; IntAct=EBI-748391, EBI-6509505;
CC Q9BWG6; Q5VVH5: IRAK1BP1; NbExp=3; IntAct=EBI-748391, EBI-9658404;
CC Q9BWG6; Q96N16: JAKMIP1; NbExp=3; IntAct=EBI-748391, EBI-2680803;
CC Q9BWG6; Q63ZY3: KANK2; NbExp=6; IntAct=EBI-748391, EBI-2556193;
CC Q9BWG6; Q9H079: KATNBL1; NbExp=3; IntAct=EBI-748391, EBI-715394;
CC Q9BWG6; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-748391, EBI-14069005;
CC Q9BWG6; Q9UIH9: KLF15; NbExp=3; IntAct=EBI-748391, EBI-2796400;
CC Q9BWG6; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-748391, EBI-3044087;
CC Q9BWG6; Q15323: KRT31; NbExp=6; IntAct=EBI-748391, EBI-948001;
CC Q9BWG6; Q14525: KRT33B; NbExp=3; IntAct=EBI-748391, EBI-1049638;
CC Q9BWG6; O76011: KRT34; NbExp=5; IntAct=EBI-748391, EBI-1047093;
CC Q9BWG6; Q92764: KRT35; NbExp=3; IntAct=EBI-748391, EBI-1058674;
CC Q9BWG6; O76015: KRT38; NbExp=9; IntAct=EBI-748391, EBI-1047263;
CC Q9BWG6; Q6A163: KRT39; NbExp=3; IntAct=EBI-748391, EBI-11958242;
CC Q9BWG6; O95678: KRT75; NbExp=3; IntAct=EBI-748391, EBI-2949715;
CC Q9BWG6; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-748391, EBI-11959885;
CC Q9BWG6; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-748391, EBI-10172150;
CC Q9BWG6; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-748391, EBI-10172290;
CC Q9BWG6; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-748391, EBI-10171774;
CC Q9BWG6; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-748391, EBI-10172052;
CC Q9BWG6; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-748391, EBI-3958099;
CC Q9BWG6; P80188: LCN2; NbExp=3; IntAct=EBI-748391, EBI-11911016;
CC Q9BWG6; O95751: LDOC1; NbExp=3; IntAct=EBI-748391, EBI-740738;
CC Q9BWG6; P48742: LHX1; NbExp=3; IntAct=EBI-748391, EBI-11990598;
CC Q9BWG6; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-748391, EBI-12039345;
CC Q9BWG6; P48059-3: LIMS1; NbExp=3; IntAct=EBI-748391, EBI-12864460;
CC Q9BWG6; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-748391, EBI-739832;
CC Q9BWG6; Q9P2M1: LRP2BP; NbExp=3; IntAct=EBI-748391, EBI-18273118;
CC Q9BWG6; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-748391, EBI-1216080;
CC Q9BWG6; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-748391, EBI-741037;
CC Q9BWG6; Q99750: MDFI; NbExp=3; IntAct=EBI-748391, EBI-724076;
CC Q9BWG6; P50222: MEOX2; NbExp=3; IntAct=EBI-748391, EBI-748397;
CC Q9BWG6; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-748391, EBI-10172526;
CC Q9BWG6; Q8TD10: MIPOL1; NbExp=6; IntAct=EBI-748391, EBI-2548751;
CC Q9BWG6; Q13064: MKRN3; NbExp=8; IntAct=EBI-748391, EBI-2340269;
CC Q9BWG6; Q6PF18: MORN3; NbExp=5; IntAct=EBI-748391, EBI-9675802;
CC Q9BWG6; Q13084: MRPL28; NbExp=3; IntAct=EBI-748391, EBI-723426;
CC Q9BWG6; Q4VC12: MSS51; NbExp=3; IntAct=EBI-748391, EBI-11599933;
CC Q9BWG6; Q5JR59-3: MTUS2; NbExp=7; IntAct=EBI-748391, EBI-11522433;
CC Q9BWG6; Q8WY64: MYLIP; NbExp=3; IntAct=EBI-748391, EBI-6952711;
CC Q9BWG6; O00160: MYO1F; NbExp=3; IntAct=EBI-748391, EBI-741792;
CC Q9BWG6; Q15742: NAB2; NbExp=3; IntAct=EBI-748391, EBI-8641936;
CC Q9BWG6; Q9ULW6: NAP1L2; NbExp=3; IntAct=EBI-748391, EBI-3911716;
CC Q9BWG6; P17568: NDUFB7; NbExp=3; IntAct=EBI-748391, EBI-1246238;
CC Q9BWG6; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-748391, EBI-10271199;
CC Q9BWG6; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-748391, EBI-945833;
CC Q9BWG6; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-748391, EBI-22310682;
CC Q9BWG6; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-748391, EBI-10302990;
CC Q9BWG6; Q5VU43: PDE4DIP; NbExp=3; IntAct=EBI-748391, EBI-1105124;
CC Q9BWG6; Q5VU43-2: PDE4DIP; NbExp=3; IntAct=EBI-748391, EBI-9640281;
CC Q9BWG6; Q9NR12: PDLIM7; NbExp=3; IntAct=EBI-748391, EBI-350517;
CC Q9BWG6; Q99471: PFDN5; NbExp=3; IntAct=EBI-748391, EBI-357275;
CC Q9BWG6; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-748391, EBI-14066006;
CC Q9BWG6; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-748391, EBI-79165;
CC Q9BWG6; Q9NWS0: PIH1D1; NbExp=3; IntAct=EBI-748391, EBI-357318;
CC Q9BWG6; O15162: PLSCR1; NbExp=4; IntAct=EBI-748391, EBI-740019;
CC Q9BWG6; Q8ND90: PNMA1; NbExp=8; IntAct=EBI-748391, EBI-302345;
CC Q9BWG6; Q9UL42: PNMA2; NbExp=3; IntAct=EBI-748391, EBI-302355;
CC Q9BWG6; Q96I34: PPP1R16A; NbExp=3; IntAct=EBI-748391, EBI-710402;
CC Q9BWG6; Q96T49: PPP1R16B; NbExp=3; IntAct=EBI-748391, EBI-10293968;
CC Q9BWG6; Q9GZV8: PRDM14; NbExp=5; IntAct=EBI-748391, EBI-3957793;
CC Q9BWG6; Q6MZQ0: PRR5L; NbExp=3; IntAct=EBI-748391, EBI-1567866;
CC Q9BWG6; O43586: PSTPIP1; NbExp=3; IntAct=EBI-748391, EBI-1050964;
CC Q9BWG6; Q9NYW8: RBAK; NbExp=3; IntAct=EBI-748391, EBI-1210429;
CC Q9BWG6; P57052: RBM11; NbExp=3; IntAct=EBI-748391, EBI-741332;
CC Q9BWG6; Q5RL73: RBM48; NbExp=3; IntAct=EBI-748391, EBI-473821;
CC Q9BWG6; Q8NG50: RDM1; NbExp=5; IntAct=EBI-748391, EBI-10288724;
CC Q9BWG6; Q04864-2: REL; NbExp=3; IntAct=EBI-748391, EBI-10829018;
CC Q9BWG6; Q15669: RHOH; NbExp=3; IntAct=EBI-748391, EBI-1244971;
CC Q9BWG6; Q6NUQ1: RINT1; NbExp=5; IntAct=EBI-748391, EBI-726876;
CC Q9BWG6; Q92753-1: RORB; NbExp=3; IntAct=EBI-748391, EBI-18560266;
CC Q9BWG6; Q96KN7: RPGRIP1; NbExp=3; IntAct=EBI-748391, EBI-1050213;
CC Q9BWG6; Q9UNE2: RPH3AL; NbExp=3; IntAct=EBI-748391, EBI-2855824;
CC Q9BWG6; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-748391, EBI-358489;
CC Q9BWG6; O60504: SORBS3; NbExp=3; IntAct=EBI-748391, EBI-741237;
CC Q9BWG6; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-748391, EBI-5235340;
CC Q9BWG6; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-748391, EBI-2212028;
CC Q9BWG6; O75558: STX11; NbExp=5; IntAct=EBI-748391, EBI-714135;
CC Q9BWG6; Q8N4C7: STX19; NbExp=3; IntAct=EBI-748391, EBI-8484990;
CC Q9BWG6; Q8N0S2: SYCE1; NbExp=3; IntAct=EBI-748391, EBI-6872807;
CC Q9BWG6; Q86VP1: TAX1BP1; NbExp=3; IntAct=EBI-748391, EBI-529518;
CC Q9BWG6; Q9UBB9: TFIP11; NbExp=5; IntAct=EBI-748391, EBI-1105213;
CC Q9BWG6; Q08117: TLE5; NbExp=3; IntAct=EBI-748391, EBI-717810;
CC Q9BWG6; Q08117-2: TLE5; NbExp=5; IntAct=EBI-748391, EBI-11741437;
CC Q9BWG6; P19237: TNNI1; NbExp=3; IntAct=EBI-748391, EBI-746692;
CC Q9BWG6; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-748391, EBI-11952721;
CC Q9BWG6; Q13077: TRAF1; NbExp=8; IntAct=EBI-748391, EBI-359224;
CC Q9BWG6; Q12933: TRAF2; NbExp=3; IntAct=EBI-748391, EBI-355744;
CC Q9BWG6; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-748391, EBI-492476;
CC Q9BWG6; Q9UDY6-2: TRIM10; NbExp=3; IntAct=EBI-748391, EBI-11981577;
CC Q9BWG6; P36406: TRIM23; NbExp=3; IntAct=EBI-748391, EBI-740098;
CC Q9BWG6; P14373: TRIM27; NbExp=6; IntAct=EBI-748391, EBI-719493;
CC Q9BWG6; O94972: TRIM37; NbExp=3; IntAct=EBI-748391, EBI-741602;
CC Q9BWG6; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-748391, EBI-5235829;
CC Q9BWG6; Q9BYV2: TRIM54; NbExp=6; IntAct=EBI-748391, EBI-2130429;
CC Q9BWG6; Q6PF05: TTC23L; NbExp=3; IntAct=EBI-748391, EBI-8656864;
CC Q9BWG6; Q5T124: UBXN11; NbExp=4; IntAct=EBI-748391, EBI-746004;
CC Q9BWG6; Q495M9: USH1G; NbExp=3; IntAct=EBI-748391, EBI-8601749;
CC Q9BWG6; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-748391, EBI-739895;
CC Q9BWG6; P08670: VIM; NbExp=3; IntAct=EBI-748391, EBI-353844;
CC Q9BWG6; Q2NL98: VMAC; NbExp=3; IntAct=EBI-748391, EBI-2803134;
CC Q9BWG6; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-748391, EBI-2799833;
CC Q9BWG6; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-748391, EBI-11957238;
CC Q9BWG6; Q9Y2K1: ZBTB1; NbExp=3; IntAct=EBI-748391, EBI-2682961;
CC Q9BWG6; O43829: ZBTB14; NbExp=3; IntAct=EBI-748391, EBI-10176632;
CC Q9BWG6; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-748391, EBI-10183064;
CC Q9BWG6; Q9NZV7: ZIM2; NbExp=3; IntAct=EBI-748391, EBI-11962760;
CC Q9BWG6; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-748391, EBI-12030590;
CC Q9BWG6; P52742: ZNF135; NbExp=3; IntAct=EBI-748391, EBI-7101455;
CC Q9BWG6; P17023: ZNF19; NbExp=3; IntAct=EBI-748391, EBI-12884200;
CC Q9BWG6; P17024: ZNF20; NbExp=3; IntAct=EBI-748391, EBI-717634;
CC Q9BWG6; O95125: ZNF202; NbExp=3; IntAct=EBI-748391, EBI-751960;
CC Q9BWG6; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-748391, EBI-11962468;
CC Q9BWG6; Q8NB15: ZNF511; NbExp=3; IntAct=EBI-748391, EBI-10269136;
CC Q9BWG6; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-748391, EBI-11035148;
CC Q9BWG6; Q8IVP9: ZNF547; NbExp=3; IntAct=EBI-748391, EBI-12895421;
CC Q9BWG6; Q9H707: ZNF552; NbExp=3; IntAct=EBI-748391, EBI-2555731;
CC Q9BWG6; Q96N77-2: ZNF641; NbExp=3; IntAct=EBI-748391, EBI-12939666;
CC Q9BWG6; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-748391, EBI-4395732;
CC Q9BWG6; P36508: ZNF76; NbExp=3; IntAct=EBI-748391, EBI-7254550;
CC Q9BWG6; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-748391, EBI-10251462;
CC Q9BWG6; Q3KNS6-3: ZNF829; NbExp=3; IntAct=EBI-748391, EBI-18036029;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000269|PubMed:17656373}. Nucleus speckle
CC {ECO:0000269|PubMed:17656373}. Note=Colocalizes with LUC7L2 and SNRNP70
CC in nuclear speckles. {ECO:0000250|UniProtKB:Q8K136}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9BWG6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BWG6-2; Sequence=VSP_021489;
CC Name=3;
CC IsoId=Q9BWG6-3; Sequence=VSP_053982, VSP_053983;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK056322; BAB71149.1; -; mRNA.
DR EMBL; AK301644; BAG63123.1; -; mRNA.
DR EMBL; AL592424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC000264; AAH00264.1; -; mRNA.
DR CCDS; CCDS55636.1; -. [Q9BWG6-2]
DR CCDS; CCDS987.1; -. [Q9BWG6-1]
DR RefSeq; NP_001191777.1; NM_001204848.1. [Q9BWG6-2]
DR RefSeq; NP_001191785.1; NM_001204856.1. [Q9BWG6-2]
DR RefSeq; NP_076946.1; NM_024041.3. [Q9BWG6-1]
DR PDB; 7DVQ; EM; 2.89 A; v=1-230.
DR PDBsum; 7DVQ; -.
DR AlphaFoldDB; Q9BWG6; -.
DR SMR; Q9BWG6; -.
DR BioGRID; 122476; 193.
DR BioGRID; 1529623; 1.
DR IntAct; Q9BWG6; 186.
DR MINT; Q9BWG6; -.
DR STRING; 9606.ENSP00000357901; -.
DR iPTMnet; Q9BWG6; -.
DR PhosphoSitePlus; Q9BWG6; -.
DR BioMuta; SCNM1; -.
DR DMDM; 74752399; -.
DR EPD; Q9BWG6; -.
DR jPOST; Q9BWG6; -.
DR MassIVE; Q9BWG6; -.
DR MaxQB; Q9BWG6; -.
DR PaxDb; Q9BWG6; -.
DR PeptideAtlas; Q9BWG6; -.
DR PRIDE; Q9BWG6; -.
DR ProteomicsDB; 79276; -. [Q9BWG6-1]
DR ProteomicsDB; 79277; -. [Q9BWG6-2]
DR Antibodypedia; 34055; 106 antibodies from 27 providers.
DR DNASU; 79005; -.
DR Ensembl; ENST00000368902.1; ENSP00000357898.1; ENSG00000163156.12. [Q9BWG6-2]
DR Ensembl; ENST00000368905.9; ENSP00000357901.4; ENSG00000163156.12. [Q9BWG6-1]
DR Ensembl; ENST00000602841.5; ENSP00000473282.1; ENSG00000163156.12. [Q9BWG6-2]
DR GeneID; 100534012; -.
DR GeneID; 79005; -.
DR KEGG; hsa:100534012; -.
DR KEGG; hsa:79005; -.
DR MANE-Select; ENST00000368905.9; ENSP00000357901.4; NM_024041.4; NP_076946.1.
DR UCSC; uc001ewz.4; human. [Q9BWG6-1]
DR CTD; 100534012; -.
DR CTD; 79005; -.
DR DisGeNET; 79005; -.
DR GeneCards; SCNM1; -.
DR HGNC; HGNC:23136; SCNM1.
DR HPA; ENSG00000163156; Low tissue specificity.
DR MIM; 608095; gene.
DR neXtProt; NX_Q9BWG6; -.
DR OpenTargets; ENSG00000163156; -.
DR PharmGKB; PA134958437; -.
DR VEuPathDB; HostDB:ENSG00000163156; -.
DR eggNOG; ENOG502QWNV; Eukaryota.
DR GeneTree; ENSGT00390000010811; -.
DR HOGENOM; CLU_059812_0_0_1; -.
DR InParanoid; Q9BWG6; -.
DR OMA; MLTVHRQ; -.
DR OrthoDB; 1557322at2759; -.
DR PhylomeDB; Q9BWG6; -.
DR TreeFam; TF332168; -.
DR PathwayCommons; Q9BWG6; -.
DR SignaLink; Q9BWG6; -.
DR BioGRID-ORCS; 100534012; 8 hits in 151 CRISPR screens.
DR BioGRID-ORCS; 79005; 117 hits in 1081 CRISPR screens.
DR ChiTaRS; SCNM1; human.
DR Pharos; Q9BWG6; Tbio.
DR PRO; PR:Q9BWG6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9BWG6; protein.
DR Bgee; ENSG00000163156; Expressed in granulocyte and 191 other tissues.
DR Genevisible; Q9BWG6; HS.
DR GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000380; P:alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0008380; P:RNA splicing; IBA:GO_Central.
DR InterPro; IPR033570; SCNM1.
DR InterPro; IPR031625; SCNM1_acidic.
DR InterPro; IPR031622; Znf-SCNM1.
DR PANTHER; PTHR32297; PTHR32297; 1.
DR Pfam; PF15805; SCNM1_acidic; 1.
DR Pfam; PF15803; zf-SCNM1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Isopeptide bond; Metal-binding;
KW mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW Reference proteome; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..230
FT /note="Sodium channel modifier 1"
FT /id="PRO_0000259635"
FT ZN_FING 42..74
FT /note="Matrin-type"
FT REGION 76..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..230
FT /note="Required for interaction with LUC7L2"
FT /evidence="ECO:0000250"
FT REGION 200..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 4..20
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 79..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..230
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 144
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 183
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8K136"
FT MOD_RES 219
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT CROSSLNK 67
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 2..36
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_021489"
FT VAR_SEQ 134..162
FT /note="PEAPGPSVSLSPMPPSEVKLQSGKISREP -> YGTGKPEVGRLRRRQMALK
FT EFSSVYSEEY (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053982"
FT VAR_SEQ 163..230
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053983"
FT HELIX 10..26
FT /evidence="ECO:0007829|PDB:7DVQ"
FT TURN 31..33
FT /evidence="ECO:0007829|PDB:7DVQ"
FT STRAND 34..36
FT /evidence="ECO:0007829|PDB:7DVQ"
FT STRAND 42..47
FT /evidence="ECO:0007829|PDB:7DVQ"
FT STRAND 52..55
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 56..63
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 66..73
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 184..198
FT /evidence="ECO:0007829|PDB:7DVQ"
FT STRAND 205..208
FT /evidence="ECO:0007829|PDB:7DVQ"
FT STRAND 213..215
FT /evidence="ECO:0007829|PDB:7DVQ"
SQ SEQUENCE 230 AA; 25949 MW; 001576EA78C61C85 CRC64;
MSFKREGDDW SQLNVLKKRR VGDLLASYIP EDEALMLRDG RFACAICPHR PVLDTLAMLT
AHRAGKKHLS SLQLFYGKKQ PGKERKQNPK HQNELRREET KAEAPLLTQT RLITQSALHR
APHYNSCCRR KYRPEAPGPS VSLSPMPPSE VKLQSGKISR EPEPAAGPQA EESATVSAPA
PMSPTRRRAL DHYLTLRSSG WIPDGRGRWV KDENVEFDSD EEEPPDLPLD
