SCNNA_ANOCA
ID SCNNA_ANOCA Reviewed; 636 AA.
AC H9GBX2;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2012, sequence version 1.
DT 03-AUG-2022, entry version 52.
DE RecName: Full=Amiloride-sensitive sodium channel subunit alpha;
DE AltName: Full=Alpha-NaCH;
DE AltName: Full=Epithelial Na(+) channel subunit alpha;
DE Short=Alpha-ENaC;
DE AltName: Full=Nonvoltage-gated sodium channel 1 subunit alpha;
DE AltName: Full=SCNEA;
GN Name=SCNN1A;
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21881562; DOI=10.1038/nature10390;
RA Alfoeldi J., Di Palma F., Grabherr M., Williams C., Kong L., Mauceli E.,
RA Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., Boissinot S.,
RA Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., Fujita M.K.,
RA Moreno R.G., ten Hallers B.F., Haussler D., Heger A., Heiman D.,
RA Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., Lara M., Novick P.A.,
RA Organ C.L., Peach S.E., Poe S., Pollock D.D., de Queiroz K., Sanger T.,
RA Searle S., Smith J.D., Smith Z., Swofford R., Turner-Maier J., Wade J.,
RA Young S., Zadissa A., Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B.,
RA Lander E.S., Breen M., Ponting C.P., Lindblad-Toh K.;
RT "The genome of the green anole lizard and a comparative analysis with birds
RT and mammals.";
RL Nature 477:587-591(2011).
CC -!- FUNCTION: Sodium permeable non-voltage-sensitive ion channel inhibited
CC by the diuretic amiloride. Mediates the electrodiffusion of the luminal
CC sodium (and water, which follows osmotically) through the apical
CC membrane of epithelial cells. Plays an essential role in electrolyte
CC and blood pressure homeostasis, but also in airway surface liquid
CC homeostasis, which is important for proper clearance of mucus.
CC {ECO:0000250|UniProtKB:P37088}.
CC -!- SUBUNIT: Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a
CC gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in
CC some organisms and can replace the alpha/SCNN1A subunit to form an
CC alternative channel with specific properties.
CC {ECO:0000250|UniProtKB:P37088}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000250|UniProtKB:P37089}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P37089}. Cell projection, cilium
CC {ECO:0000250|UniProtKB:P37088}. Cytoplasmic granule
CC {ECO:0000250|UniProtKB:P37088}. Cytoplasm
CC {ECO:0000250|UniProtKB:P37088}. Cytoplasmic vesicle, secretory vesicle,
CC acrosome {ECO:0000250|UniProtKB:P37089}. Cell projection, cilium,
CC flagellum {ECO:0000250|UniProtKB:P37089}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. SCNN1A subfamily. {ECO:0000305}.
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DR EMBL; AAWZ02026577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003226512.1; XM_003226464.2.
DR AlphaFoldDB; H9GBX2; -.
DR SMR; H9GBX2; -.
DR STRING; 28377.ENSACAP00000006638; -.
DR Ensembl; ENSACAT00000006784; ENSACAP00000006638; ENSACAG00000006704.
DR GeneID; 100565527; -.
DR KEGG; acs:100565527; -.
DR CTD; 6337; -.
DR eggNOG; KOG4294; Eukaryota.
DR GeneTree; ENSGT00940000160952; -.
DR HOGENOM; CLU_020415_0_0_1; -.
DR InParanoid; H9GBX2; -.
DR OMA; EKTRQCK; -.
DR OrthoDB; 686369at2759; -.
DR TreeFam; TF330663; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000006704; Expressed in kidney and 2 other tissues.
DR GO; GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0034706; C:sodium channel complex; IBA:GO_Central.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central.
DR GO; GO:0035725; P:sodium ion transmembrane transport; ISS:UniProtKB.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR PANTHER; PTHR11690; PTHR11690; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR TIGRFAMs; TIGR00859; ENaC; 1.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell projection; Cilium; Cytoplasm; Cytoplasmic vesicle;
KW Flagellum; Ion channel; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium channel; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..636
FT /note="Amiloride-sensitive sodium channel subunit alpha"
FT /id="PRO_0000432909"
FT TOPO_DOM 1..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P37089"
FT TRANSMEM 78..98
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..549
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P37089"
FT TRANSMEM 550..570
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 571..636
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P37089"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 636 AA; 73384 MW; A08D8581ADC63961 CRC64;
MKSENQPEDK RIGKLKREAN MQKMKEAAEV EEKKKEENEA LVGFFHSYQE LFQFFCNNTT
IHGAIRLVCS KKNRMKTAFW SILFFFTFGL MYWQFGIIYR EYFSFPVNLN LNLNSDRFTF
PAVTLCTLNP YRYSALQNEL AELDHITQKT LMDLYKYDMS QGQNNRKAQL SRKRSYRSLH
YHVSRHPLHR YKRDSQASIE DNNTQVDKND WKIAFSVCNE NNTDCFKQMY SSGVDAVREW
YSFHYINILS RIPNAKSLDE SDFASFIYAC RFNEVTCDKA NYTHFHHPIY GNCYTFNANS
SNLWMSSLPG INNGLSLVVR TEQNDFIPLL STVTGARVMV HNQNEPAFMD EGGFNVRPGI
ETSISMRKET TNRLGGTYSD CTEDGSDVPV KNLYTSRYTE QVCIRSCFQN SIVERCGCGH
YFYPLPSGAV YCDYAKHKAW GYCYYKLLAE FKADLLGCFT KCRKPCKVTE YQLSAGYSRW
PSTASEAWVF HILSRQNQYN ITSKRNGVAK VNIFFEQWNH KSNGESPAFT VVTLLSQLGS
QWSLWFGSSV LSVVELVELI LDFIAITCIL AIHWLNMNRS SDLPIPTSNT TDTFHNVLPP
PNTLPRASVD PDVITLPSYK SLESLDLRRV SSQQTE
