SCNNB_PELSI
ID SCNNB_PELSI Reviewed; 607 AA.
AC K7FQW8;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Amiloride-sensitive sodium channel subunit beta;
DE AltName: Full=Beta-NaCH;
DE AltName: Full=Epithelial Na(+) channel subunit beta;
DE Short=Beta-ENaC;
DE AltName: Full=Nonvoltage-gated sodium channel 1 subunit beta;
DE AltName: Full=SCNEB;
GN Name=SCNN1B;
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000312|Ensembl:ENSPSIP00000010428};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Soft-shell turtle genome consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sodium permeable non-voltage-sensitive ion channel inhibited
CC by the diuretic amiloride. Mediates the electrodiffusion of the luminal
CC sodium (and water, which follows osmotically) through the apical
CC membrane of epithelial cells. Plays an essential role in electrolyte
CC and blood pressure homeostasis, but also in airway surface liquid
CC homeostasis, which is important for proper clearance of mucus.
CC {ECO:0000250|UniProtKB:P51168}.
CC -!- SUBUNIT: Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a
CC gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in
CC some organisms and can replace the alpha/SCNN1A subunit to form an
CC alternative channel with specific properties.
CC {ECO:0000250|UniProtKB:P51168}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000250|UniProtKB:P37090}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P37089}. Cytoplasmic vesicle membrane
CC {ECO:0000250|UniProtKB:P37090}. Note=Apical membrane of epithelial
CC cells. {ECO:0000250|UniProtKB:P37090}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. SCNN1B subfamily. {ECO:0000305}.
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DR EMBL; AGCU01105098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01105099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01105100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01105101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01105102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FQW8; -.
DR SMR; K7FQW8; -.
DR STRING; 13735.ENSPSIP00000010428; -.
DR Ensembl; ENSPSIT00000010481; ENSPSIP00000010428; ENSPSIG00000009380.
DR eggNOG; KOG4294; Eukaryota.
DR GeneTree; ENSGT00940000160893; -.
DR HOGENOM; CLU_020415_0_0_1; -.
DR OMA; NLTIWNH; -.
DR TreeFam; TF330663; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR GO; GO:0034706; C:sodium channel complex; IEA:Ensembl.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0050699; F:WW domain binding; IEA:Ensembl.
DR GO; GO:0032341; P:aldosterone metabolic process; IEA:Ensembl.
DR GO; GO:0014824; P:artery smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0071468; P:cellular response to acidic pH; IEA:Ensembl.
DR GO; GO:1904045; P:cellular response to aldosterone; IEA:Ensembl.
DR GO; GO:0036254; P:cellular response to amiloride; IEA:Ensembl.
DR GO; GO:0006883; P:cellular sodium ion homeostasis; IEA:Ensembl.
DR GO; GO:0042045; P:epithelial fluid transport; IEA:Ensembl.
DR GO; GO:0034101; P:erythrocyte homeostasis; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0002269; P:leukocyte activation involved in inflammatory response; IEA:Ensembl.
DR GO; GO:0070254; P:mucus secretion; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0050891; P:multicellular organismal water homeostasis; IEA:Ensembl.
DR GO; GO:0002283; P:neutrophil activation involved in immune response; IEA:Ensembl.
DR GO; GO:0070944; P:neutrophil-mediated killing of bacterium; IEA:Ensembl.
DR GO; GO:0055075; P:potassium ion homeostasis; IEA:Ensembl.
DR GO; GO:0032094; P:response to food; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0035725; P:sodium ion transmembrane transport; ISS:UniProtKB.
DR GO; GO:0097274; P:urea homeostasis; IEA:Ensembl.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR PANTHER; PTHR11690; PTHR11690; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR TIGRFAMs; TIGR00859; ENaC; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cytoplasmic vesicle; Ion channel; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium channel; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..607
FT /note="Amiloride-sensitive sodium channel subunit beta"
FT /id="PRO_0000432890"
FT TOPO_DOM 1..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P37089"
FT TRANSMEM 51..71
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..551
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P37089"
FT TRANSMEM 552..572
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 573..607
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P37089"
SQ SEQUENCE 607 AA; 69198 MW; 9D42BDEA74B4D90D CRC64;
MNLKKYFIRV LHRLQKGPGY TYKELLVWYC DNTNTHGPKR IIREGPKKKF IWFFLTLLFA
SLVFWQWGIL ITTYLSYSVS SSLSIGFKTM KFPAVTVCNA SPFKYSKVRH LLRELDELTE
AALERILQSK NRDATSALPL NSSETPSQTL NLRLWNQIPL VLIDESDPER PVIIDLFETD
ESGSGAQPNN SSPALVNVTS EAKKQKVAMK LCSRKALPNC IYRNFTSAAQ AVTEWYILQS
TSIFAKIPRN ETVEMGYQPE DMILACLYGA EPCSYRNFTP IYHPDHGNCY IFNWGKDEEA
LFSSNPGAEF GLKLILDISQ QDYIPYLTST AGARLMLHEQ RSFPFLKDLG IYAMSGTETS
IGVLVDELER MGFPYSDCTM NGSDVPVKNL YNEYNTTYSI QACLRSCFQA QMFETCGCGH
YLFPLPEGVS YCNSEDDPDW AYCYSSLRSS IGHRQFCIDS CKETCNDIQY KMTISMADWP
SEASEEFQYM QHPLTYERDQ SRNATLDRNG IIKLNIYFQE YNYRTISESA ATTIVWLLSS
LGGQFGFWMG GSVLCLIEFG EIIIDFLWIT VIKISNWGKG LKQKRARAQY PDAPPTVSEL
VEAHINL
