ID   SCOA_MYCTO              Reviewed;         248 AA.
AC   P9WPW4; L0TCJ8; O06167; P63648;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit A;
DE            EC=2.8.3.5;
DE   AltName: Full=Succinyl-CoA:3-oxoacid CoA-transferase;
DE            Short=OXCT A;
GN   Name=scoA; OrderedLocusNames=MT2579;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate;
CC         Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973,
CC         ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5;
CC   -!- SUBUNIT: Heterodimer of a subunit A and a subunit B. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase subunit A family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK46883.1; -; Genomic_DNA.
DR   PIR; H70550; H70550.
DR   RefSeq; WP_003412786.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WPW4; -.
DR   SMR; P9WPW4; -.
DR   EnsemblBacteria; AAK46883; AAK46883; MT2579.
DR   GeneID; 45426498; -.
DR   KEGG; mtc:MT2579; -.
DR   PATRIC; fig|83331.31.peg.2781; -.
DR   HOGENOM; CLU_019942_2_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0008260; F:3-oxoacid CoA-transferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR012792; 3-oxoacid_CoA-transf_A.
DR   InterPro; IPR004165; CoA_trans_fam_I.
DR   InterPro; IPR004163; CoA_transf_BS.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR13707; PTHR13707; 1.
DR   Pfam; PF01144; CoA_trans; 1.
DR   SMART; SM00882; CoA_trans; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR02429; pcaI_scoA_fam; 1.
DR   PROSITE; PS01273; COA_TRANSF_1; 1.
PE   3: Inferred from homology;
KW   Transferase.
FT   CHAIN           1..248
FT                   /note="Probable succinyl-CoA:3-ketoacid coenzyme A
FT                   transferase subunit A"
FT                   /id="PRO_0000426881"
FT   BINDING         24..30
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   248 AA;  26276 MW;  81340193CC48EBD1 CRC64;
     MDKVVATAAE AVADIANGSS LAVGGFGLCG IPEALIAALV DSGVTDLETV SNNCGIDGVG
     LGLLLQHKRI RRTVSSYVGE NKEFARQFLA GELEVELTPQ GTLAERLRAG GMGIPAFYTP
     AGVGTQVADG GLPWRYDASG GVAVVSPAKE TREFDGVTYV LERGIRTDFA LVHAWQGDRH
     GNLMYRHAAA NFNPECASAG RITIAEVEHL VEPGEIDPAT VHTPGVFVHR VVHVPNPAKK
     IERETVRQ