SCOB_HELPY
ID SCOB_HELPY Reviewed; 207 AA.
AC P56007;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Succinyl-CoA:3-ketoacid coenzyme A transferase subunit B;
DE EC=2.8.3.5;
DE AltName: Full=OXCT B;
DE AltName: Full=Succinyl-CoA:3-oxoacid CoA-transferase;
GN Name=scoB; OrderedLocusNames=HP_0692;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC STRAIN=69A;
RX PubMed=9325289; DOI=10.1074/jbc.272.41.25659;
RA Corthesy-Theulaz I.E., Bergonzelli G.E., Henry H., Bachmann D.,
RA Schorderet D.F., Blum A.L., Ornston L.N.;
RT "Cloning and characterization of Helicobacter pylori succinyl
RT CoA:acetoacetate CoA-transferase, a novel prokaryotic member of the CoA-
RT transferase family.";
RL J. Biol. Chem. 272:25659-25667(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate;
CC Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973,
CC ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10034};
CC -!- SUBUNIT: Heterodimer of a subunit A and a subunit B.
CC -!- INTERACTION:
CC P56007; P56006: scoA; NbExp=3; IntAct=EBI-7724043, EBI-7723842;
CC -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase subunit B family.
CC {ECO:0000305}.
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DR EMBL; AE000511; AAD07744.1; -; Genomic_DNA.
DR EMBL; AJ000086; CAA03917.1; -; Genomic_DNA.
DR PIR; D64606; D64606.
DR RefSeq; NP_207486.1; NC_000915.1.
DR RefSeq; WP_001206261.1; NC_018939.1.
DR PDB; 3RRL; X-ray; 2.29 A; B/D=1-207.
DR PDBsum; 3RRL; -.
DR AlphaFoldDB; P56007; -.
DR SMR; P56007; -.
DR DIP; DIP-3482N; -.
DR IntAct; P56007; 4.
DR MINT; P56007; -.
DR STRING; 85962.C694_03565; -.
DR PaxDb; P56007; -.
DR DNASU; 899313; -.
DR EnsemblBacteria; AAD07744; AAD07744; HP_0692.
DR KEGG; hpy:HP_0692; -.
DR PATRIC; fig|85962.47.peg.740; -.
DR eggNOG; COG2057; Bacteria.
DR OMA; VAMMHTN; -.
DR PhylomeDB; P56007; -.
DR BioCyc; MetaCyc:HP_RS03385-MON; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0008260; F:3-oxoacid CoA-transferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008775; F:acetate CoA-transferase activity; IBA:GO_Central.
DR GO; GO:0008410; F:CoA-transferase activity; IBA:GO_Central.
DR InterPro; IPR012791; 3-oxoacid_CoA-transf_B.
DR InterPro; IPR004165; CoA_trans_fam_I.
DR InterPro; IPR004164; CoA_transf_AS.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR13707; PTHR13707; 1.
DR Pfam; PF01144; CoA_trans; 1.
DR SMART; SM00882; CoA_trans; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR TIGRFAMs; TIGR02428; pcaJ_scoB_fam; 1.
DR PROSITE; PS01274; COA_TRANSF_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Transferase.
FT CHAIN 1..207
FT /note="Succinyl-CoA:3-ketoacid coenzyme A transferase
FT subunit B"
FT /id="PRO_0000157921"
FT ACT_SITE 43
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10034"
FT CONFLICT 70
FT /note="I -> V (in Ref. 2; CAA03917)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="K -> R (in Ref. 2; CAA03917)"
FT /evidence="ECO:0000305"
FT CONFLICT 206
FT /note="R -> H (in Ref. 2; CAA03917)"
FT /evidence="ECO:0000305"
FT HELIX 2..10
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 18..21
FT /evidence="ECO:0007829|PDB:3RRL"
FT HELIX 25..33
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 34..36
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 39..42
FT /evidence="ECO:0007829|PDB:3RRL"
FT TURN 43..45
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 46..49
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 67..69
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 72..78
FT /evidence="ECO:0007829|PDB:3RRL"
FT HELIX 81..89
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 94..98
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 101..104
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 112..114
FT /evidence="ECO:0007829|PDB:3RRL"
FT TURN 115..117
FT /evidence="ECO:0007829|PDB:3RRL"
FT HELIX 125..131
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 132..138
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 148..153
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 159..162
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 165..168
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 170..177
FT /evidence="ECO:0007829|PDB:3RRL"
FT STRAND 180..186
FT /evidence="ECO:0007829|PDB:3RRL"
FT HELIX 192..198
FT /evidence="ECO:0007829|PDB:3RRL"
SQ SEQUENCE 207 AA; 22263 MW; 1A4AC53C70A90F81 CRC64;
MREAIIKRAA KELKEGMYVN LGIGLPTLVA NEVSGMNIVF QSENGLLGIG AYPLEGSVDA
DLINAGKETI TVVPGASFFN SADSFAMIRG GHIDLAILGG MEVSQNGDLA NWMIPKKLIK
GMGGAMDLVH GAKKVIVIME HCNKYGESKV KKECSLPLTG KGVVHQLITD LAVFEFSNNA
MKLVELQEGV SLDQVKEKTE AEFEVRL
