ID   SCOB_MYCTU              Reviewed;         218 AA.
AC   P9WPW3; L0TCQ5; O06166; P63650;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit B;
DE            EC=2.8.3.5;
DE   AltName: Full=OXCT B;
DE   AltName: Full=Succinyl-CoA:3-oxoacid CoA-transferase;
GN   Name=scoB; OrderedLocusNames=Rv2503c; ORFNames=MTCY07A7.09c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate;
CC         Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973,
CC         ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10034};
CC   -!- SUBUNIT: Heterodimer of a subunit A and a subunit B. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP45297.1; -; Genomic_DNA.
DR   PIR; G70550; G70550.
DR   RefSeq; NP_217019.1; NC_000962.3.
DR   RefSeq; WP_003412782.1; NZ_NVQJ01000063.1.
DR   AlphaFoldDB; P9WPW3; -.
DR   SMR; P9WPW3; -.
DR   STRING; 83332.Rv2503c; -.
DR   PaxDb; P9WPW3; -.
DR   DNASU; 888502; -.
DR   GeneID; 45426497; -.
DR   GeneID; 888502; -.
DR   KEGG; mtu:Rv2503c; -.
DR   TubercuList; Rv2503c; -.
DR   eggNOG; COG2057; Bacteria.
DR   OMA; VAMMHTN; -.
DR   PhylomeDB; P9WPW3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0008260; F:3-oxoacid CoA-transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008775; F:acetate CoA-transferase activity; IBA:GO_Central.
DR   GO; GO:0008410; F:CoA-transferase activity; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IEP:MTBBASE.
DR   InterPro; IPR012791; 3-oxoacid_CoA-transf_B.
DR   InterPro; IPR004165; CoA_trans_fam_I.
DR   InterPro; IPR004164; CoA_transf_AS.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR13707; PTHR13707; 1.
DR   Pfam; PF01144; CoA_trans; 1.
DR   SMART; SM00882; CoA_trans; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR02428; pcaJ_scoB_fam; 1.
DR   PROSITE; PS01274; COA_TRANSF_2; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Transferase.
FT   CHAIN           1..218
FT                   /note="Probable succinyl-CoA:3-ketoacid coenzyme A
FT                   transferase subunit B"
FT                   /id="PRO_0000157923"
FT   ACT_SITE        50
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10034"
SQ   SEQUENCE   218 AA;  22898 MW;  321B0AB5BCBFF7D9 CRC64;
     MSAPGWSRDE MAARVAAEFE DGQYVNLGIG MPTLIPNHIP DGVHVVLHSE NGILGVGPYP
     RREDVDADLI NAGKETVTTL PGAAFFSSST SFGIIRGGHL DVAVLGAMQV SVTGDLANWM
     IPGKMVKGMG GAMDLVHGAR KVIVMMEHTA KDGSPKILER CTLPLTGVGC VDRIVTELAV
     IDVCADGLHL VQTAPGVSVD EVVAKTQPPL VLRDLATQ