BETI1_CHRSD
ID BETI1_CHRSD Reviewed; 202 AA.
AC Q1QXD9;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=HTH-type transcriptional regulator BetI 1 {ECO:0000255|HAMAP-Rule:MF_00768};
GN Name=betI1 {ECO:0000255|HAMAP-Rule:MF_00768}; Synonyms=betI;
GN OrderedLocusNames=Csal_1516;
OS Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 /
OS NCIMB 13768 / 1H11).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Chromohalobacter.
OX NCBI_TaxID=290398;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11;
RX PubMed=22675587; DOI=10.4056/sigs.2285059;
RA Copeland A., O'Connor K., Lucas S., Lapidus A., Berry K.W., Detter J.C.,
RA Del Rio T.G., Hammon N., Dalin E., Tice H., Pitluck S., Bruce D.,
RA Goodwin L., Han C., Tapia R., Saunders E., Schmutz J., Brettin T.,
RA Larimer F., Land M., Hauser L., Vargas C., Nieto J.J., Kyrpides N.C.,
RA Ivanova N., Goker M., Klenk H.P., Csonka L.N., Woyke T.;
RT "Complete genome sequence of the halophilic and highly halotolerant
RT Chromohalobacter salexigens type strain (1H11(T)).";
RL Stand. Genomic Sci. 5:379-388(2011).
CC -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC glycine betaine. It represses transcription of the choline transporter
CC BetT and the genes of BetAB involved in the synthesis of glycine
CC betaine (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC choline pathway [regulation].
CC -!- SEQUENCE CAUTION:
CC Sequence=ABE58869.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CP000285; ABE58869.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q1QXD9; -.
DR SMR; Q1QXD9; -.
DR STRING; 290398.Csal_1516; -.
DR EnsemblBacteria; ABE58869; ABE58869; Csal_1516.
DR KEGG; csa:Csal_1516; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069356_15_4_6; -.
DR UniPathway; UPA00529; -.
DR Proteomes; UP000000239; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00768; HTH_type_BetI; 1.
DR InterPro; IPR039538; BetI_C.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR017757; Tscrpt_rep_BetI.
DR Pfam; PF13977; TetR_C_6; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF48498; SSF48498; 1.
DR TIGRFAMs; TIGR03384; betaine_BetI; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..202
FT /note="HTH-type transcriptional regulator BetI 1"
FT /id="PRO_0000245317"
FT DOMAIN 8..68
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
FT DNA_BIND 31..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
SQ SEQUENCE 202 AA; 22805 MW; 682F65B704CC208E CRC64;
MPKLGMQPIR RRQLIQATLE TIDDVGLADA TIARIAKRAG VSAGIISHYF GGKDGLLESA
MRQILWDLGD AVARRRAQGV ESPREHIRAI IDGNFDRSQV NKTVMKTWLA FWSVSMHRPD
LQRLQRVNDR WLYSNLCHHF RRCLPRPEAQ QAARGLAAMI DGLWLRGALA PQGIDVDRAR
QLAYDYVEEQ LARSTSHAPT DA