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BETI1_CHRSD
ID   BETI1_CHRSD             Reviewed;         202 AA.
AC   Q1QXD9;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=HTH-type transcriptional regulator BetI 1 {ECO:0000255|HAMAP-Rule:MF_00768};
GN   Name=betI1 {ECO:0000255|HAMAP-Rule:MF_00768}; Synonyms=betI;
GN   OrderedLocusNames=Csal_1516;
OS   Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 /
OS   NCIMB 13768 / 1H11).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Chromohalobacter.
OX   NCBI_TaxID=290398;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11;
RX   PubMed=22675587; DOI=10.4056/sigs.2285059;
RA   Copeland A., O'Connor K., Lucas S., Lapidus A., Berry K.W., Detter J.C.,
RA   Del Rio T.G., Hammon N., Dalin E., Tice H., Pitluck S., Bruce D.,
RA   Goodwin L., Han C., Tapia R., Saunders E., Schmutz J., Brettin T.,
RA   Larimer F., Land M., Hauser L., Vargas C., Nieto J.J., Kyrpides N.C.,
RA   Ivanova N., Goker M., Klenk H.P., Csonka L.N., Woyke T.;
RT   "Complete genome sequence of the halophilic and highly halotolerant
RT   Chromohalobacter salexigens type strain (1H11(T)).";
RL   Stand. Genomic Sci. 5:379-388(2011).
CC   -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC       glycine betaine. It represses transcription of the choline transporter
CC       BetT and the genes of BetAB involved in the synthesis of glycine
CC       betaine (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC       choline pathway [regulation].
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABE58869.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP000285; ABE58869.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q1QXD9; -.
DR   SMR; Q1QXD9; -.
DR   STRING; 290398.Csal_1516; -.
DR   EnsemblBacteria; ABE58869; ABE58869; Csal_1516.
DR   KEGG; csa:Csal_1516; -.
DR   eggNOG; COG1309; Bacteria.
DR   HOGENOM; CLU_069356_15_4_6; -.
DR   UniPathway; UPA00529; -.
DR   Proteomes; UP000000239; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00768; HTH_type_BetI; 1.
DR   InterPro; IPR039538; BetI_C.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR017757; Tscrpt_rep_BetI.
DR   Pfam; PF13977; TetR_C_6; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   TIGRFAMs; TIGR03384; betaine_BetI; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..202
FT                   /note="HTH-type transcriptional regulator BetI 1"
FT                   /id="PRO_0000245317"
FT   DOMAIN          8..68
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
FT   DNA_BIND        31..50
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
SQ   SEQUENCE   202 AA;  22805 MW;  682F65B704CC208E CRC64;
     MPKLGMQPIR RRQLIQATLE TIDDVGLADA TIARIAKRAG VSAGIISHYF GGKDGLLESA
     MRQILWDLGD AVARRRAQGV ESPREHIRAI IDGNFDRSQV NKTVMKTWLA FWSVSMHRPD
     LQRLQRVNDR WLYSNLCHHF RRCLPRPEAQ QAARGLAAMI DGLWLRGALA PQGIDVDRAR
     QLAYDYVEEQ LARSTSHAPT DA
 
 
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