SCONB_ASPFC
ID SCONB_ASPFC Reviewed; 696 AA.
AC B0XTS1;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Probable E3 ubiquitin ligase complex SCF subunit sconB;
DE AltName: Full=Sulfur controller B;
DE AltName: Full=Sulfur metabolite repression control protein B;
GN Name=sconB; ORFNames=AFUB_029730;
OS Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=451804;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the SCF(sconB) E3 ubiquitin ligase complex
CC involved in the regulation of sulfur metabolite repression, probably by
CC mediating the inactivation or degradation of the metR transcription
CC factor. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Component of the SCF(sconB) E3 ubiquitin ligase complex.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat MET30/SCONB/SCON-2 family.
CC {ECO:0000305}.
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DR EMBL; DS499595; EDP54913.1; -; Genomic_DNA.
DR AlphaFoldDB; B0XTS1; -.
DR SMR; B0XTS1; -.
DR EnsemblFungi; EDP54913; EDP54913; AFUB_029730.
DR VEuPathDB; FungiDB:AFUB_029730; -.
DR HOGENOM; CLU_000288_103_1_1; -.
DR PhylomeDB; B0XTS1; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001699; Unassembled WGS sequence.
DR GO; GO:0043224; C:nuclear SCF ubiquitin ligase complex; IEA:EnsemblFungi.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0043130; F:ubiquitin binding; IEA:EnsemblFungi.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IEA:EnsemblFungi.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:EnsemblFungi.
DR GO; GO:0000083; P:regulation of transcription involved in G1/S transition of mitotic cell cycle; IEA:EnsemblFungi.
DR GO; GO:0046685; P:response to arsenic-containing substance; IEA:EnsemblFungi.
DR GO; GO:0046686; P:response to cadmium ion; IEA:EnsemblFungi.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation pathway;
KW WD repeat.
FT CHAIN 1..696
FT /note="Probable E3 ubiquitin ligase complex SCF subunit
FT sconB"
FT /id="PRO_0000397246"
FT DOMAIN 193..239
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 365..402
FT /note="WD 1"
FT REPEAT 405..444
FT /note="WD 2"
FT REPEAT 446..482
FT /note="WD 3"
FT REPEAT 484..525
FT /note="WD 4"
FT REPEAT 579..622
FT /note="WD 5"
FT REPEAT 623..662
FT /note="WD 6"
FT REPEAT 665..696
FT /note="WD 7"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 696 AA; 77712 MW; 0377045046AA18C7 CRC64;
MDAHELSFRD GHGSSTSTMK DGCASAEKPH YLPGDSSFTS VFGPSETVED VETEPGSTQD
KPHSFNTQKP IRENLAGKNV APFLARHIPE QYAPLGSQGG QPVEISSANS KYCYRHRPDL
KCRRQADEPT MDKLQRELET LPQSDQQGIA HAWSIFSAAP AKHRKLILQG IMAQCCFPQL
SFISATVRDL IRIDFLTALP PEISFKILCY LDTTSLCKAA QVSRRWRALA DDDVVWHRMC
EQHIHRKCKK CGWGLPLLDR KRLRESKREI ERRAATWDVS KQPAGIEGSS ATIETAAAGS
KRKPESGKED TAMVKRQCTS IVSQSEQNED YFKTRYRPWK EVYKDRFKVG TNWKYGRCST
RVFKGHSNGI MCLQFEDNIL ATGSYDATIK IWDTETGEEL RTLKGHQSGI RCLQFDDTKL
ISGSMDHTLK VWNWRTGECI STYSGHRGGV VGLHFDATIL ASGSVDKTVK IWNFEDKSTC
LLRGHTDWVN AVRVDSASRT VFSASDDCTV KLWDLDTKSC IRTFHGHVGQ VQQVVPLPRE
FEFEDHDVEC ENDNVSVTSG DSPAASPQAL PGFDGQTSDT PSSAFGPAFD DGRPSPPRYI
VTSALDSTIR LWETSSGRCL RTFFGHLEGV WALAADTLRI VSGAEDRMVK IWDPRTGKCE
RTFTGHSGPV TCIGLGDSRF ATGSEDCEVR MYSFQT
