ID   BETI2_CHRSD             Reviewed;         207 AA.
AC   Q9L4K2;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=HTH-type transcriptional regulator BetI 2 {ECO:0000255|HAMAP-Rule:MF_00768};
GN   Name=betI2 {ECO:0000255|HAMAP-Rule:MF_00768}; Synonyms=betI;
OS   Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 /
OS   NCIMB 13768 / 1H11).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Chromohalobacter.
OX   NCBI_TaxID=290398;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10708384; DOI=10.1099/00221287-146-2-455;
RA   Canovas D., Vargas C., Kneip S., Moron M.J., Ventosa A., Bremer E.,
RA   Nieto J.J.;
RT   "Genes for the synthesis of the osmoprotectant glycine betaine from choline
RT   in the moderately halophilic bacterium Halomonas elongata DSM 3043.";
RL   Microbiology 146:455-463(2000).
CC   -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC       glycine betaine. It represses transcription of the choline transporter
CC       BetT and the genes of BetAB involved in the synthesis of glycine
CC       betaine (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC       choline pathway [regulation].
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DR   EMBL; AJ238780; CAB77174.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9L4K2; -.
DR   SMR; Q9L4K2; -.
DR   UniPathway; UPA00529; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00768; HTH_type_BetI; 1.
DR   InterPro; IPR039538; BetI_C.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR017757; Tscrpt_rep_BetI.
DR   Pfam; PF13977; TetR_C_6; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   TIGRFAMs; TIGR03384; betaine_BetI; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..207
FT                   /note="HTH-type transcriptional regulator BetI 2"
FT                   /id="PRO_0000070583"
FT   DOMAIN          8..68
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
FT   DNA_BIND        31..50
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
SQ   SEQUENCE   207 AA;  22858 MW;  1FD1A1D1E83F23E6 CRC64;
     MPKVGMEPIR RQQLIKATMA AIDEVGLAEA TVMRIARHAG VSAGIISHYF GGKDGLLEAT
     MRQILTDLSD AVAARRHALE DDSPRAHIGA IIEGNFDRTQ VTGPAAKTWL AFWASSMHKP
     VLQRLQYVND RRLYANLCHQ FQRVMPKADA RNAARGLAAM IDGLWLRGAL TPEGLDAAEA
     RYLAHTYLDQ LLTHYGCYQD ASTADFK