ID   SCONB_PENRW             Reviewed;         673 AA.
AC   B6GZA1;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Probable E3 ubiquitin ligase complex SCF subunit sconB;
DE   AltName: Full=Sulfur controller B;
DE   AltName: Full=Sulfur metabolite repression control protein B;
GN   Name=sconB; ORFNames=Pc12g12850;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: Component of the SCF(sconB) E3 ubiquitin ligase complex
CC       involved in the regulation of sulfur metabolite repression, probably by
CC       mediating the inactivation or degradation of the metR transcription
CC       factor. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the SCF(sconB) E3 ubiquitin ligase complex.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MET30/SCONB/SCON-2 family.
CC       {ECO:0000305}.
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DR   EMBL; AM920427; CAP80912.1; -; Genomic_DNA.
DR   RefSeq; XP_002558093.1; XM_002558047.1.
DR   AlphaFoldDB; B6GZA1; -.
DR   SMR; B6GZA1; -.
DR   STRING; 1108849.XP_002558093.1; -.
DR   PRIDE; B6GZA1; -.
DR   EnsemblFungi; CAP80912; CAP80912; PCH_Pc12g12850.
DR   GeneID; 8317408; -.
DR   KEGG; pcs:Pc12g12850; -.
DR   VEuPathDB; FungiDB:PCH_Pc12g12850; -.
DR   eggNOG; KOG0274; Eukaryota.
DR   HOGENOM; CLU_000288_103_1_1; -.
DR   OMA; KMCEQHI; -.
DR   OrthoDB; 617388at2759; -.
DR   BioCyc; PCHR:PC12G12850-MON; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000000724; Contig Pc00c12.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..673
FT                   /note="Probable E3 ubiquitin ligase complex SCF subunit
FT                   sconB"
FT                   /id="PRO_0000397254"
FT   DOMAIN          165..211
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          341..378
FT                   /note="WD 1"
FT   REPEAT          381..420
FT                   /note="WD 2"
FT   REPEAT          422..458
FT                   /note="WD 3"
FT   REPEAT          460..500
FT                   /note="WD 4"
FT   REPEAT          554..599
FT                   /note="WD 5"
FT   REPEAT          602..639
FT                   /note="WD 6"
FT   REPEAT          642..673
FT                   /note="WD 7"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   673 AA;  75552 MW;  F2CF036D9930A2DD CRC64;
     MADRPEPSST QQSLVVPDAG VSANADSNRS LPRKDTDNTT QTLEELARQN VAPFLAKYQP
     RQYAPLRSQV SAPSERHMVN AGYCYRHQPD SKCSRRQADE QSMTQLQSEL NLLPQSDQQG
     IAHVWSLFSA APAKQRTLML QGILAQSCFP QLSYISASVR ELIRIDFLAA LPPELSFKIL
     RYLDTASLCR AAQVSPRWRA LADDDVVWHR MCEQHIRRKC NKCGWGLPLL DRKRLREAKR
     EIELRATNWG NNKPAVGSSE AAMVESCSTV QPPASGKRTL ESDEEAAALA KRHCASSPQS
     PEVDESYFKT RYRPWKEVYR DRFVVGMNWK HKRCSIKVFK GHRDSVMCLQ FEDNILMTGS
     YDATVKIWDT DTGEELRTLK GHVAGVRCLQ FDDTKLITGS LDRSIRVWNW RTGECISKYN
     GHAEAVIALH FDCTLLASAS VDRTVKIWNF KDKSTFVLPH PQGVNAVKID SVSRTVLTAC
     DDGAARLWDL DTKTCIRVFH NHIGAVQQVI ALPREIELEN HLADCENDHV GTSSQGGDNI
     LSTLSPLLEA TSPSHPNSPF GSSFDQDQDR IESPRYILTS GVDTTIRLWE TSTGRCLRTF
     FGHLEGIWAL SADTLRIASG GMDRMVKIWD PRIPTGQDTY EGHSAAVNCI GLSDSRFITG
     GDDYQVRMYD FRA