ID   SCP1_LOTGI              Reviewed;         336 AA.
AC   B3A0P7;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=SCP domain-containing protein 1;
DE   AltName: Full=Uncharacterized shell protein 2;
DE            Short=LUSP-2;
DE   Flags: Precursor;
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND IDENTIFICATION.
RC   TISSUE=Mantle {ECO:0000269|Ref.1};
RA   Richardson P., Lucas S., Rokhsar D., Wang M., Lindquist E.A.;
RT   "DOE Joint Genome Institute Lottia gigantea EST project.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 54-61; 130-159; 163-198; 222-275 AND 311-326,
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Shell;
RX   PubMed=23145877; DOI=10.1111/febs.12062;
RA   Marie B., Jackson D.J., Ramos-Silva P., Zanella-Cleon I., Guichard N.,
RA   Marin F.;
RT   "The shell-forming proteome of Lottia gigantea reveals both deep
RT   conservations and lineage-specific novelties.";
RL   FEBS J. 280:214-232(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23145877}.
CC   -!- TISSUE SPECIFICITY: Component of the acid-insoluble and acid-soluble
CC       organic matrix of calcified layers of the shell (at protein level).
CC       {ECO:0000269|PubMed:23145877}.
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DR   EMBL; FC619992; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; FC623414; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; B3A0P7; -.
DR   SMR; B3A0P7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..336
FT                   /note="SCP domain-containing protein 1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000415257"
FT   DOMAIN          175..292
FT                   /note="SCP"
FT                   /evidence="ECO:0000255"
FT   REGION          73..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        213
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        257
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   336 AA;  36880 MW;  AA6A33B03E085B1D CRC64;
     MEFKLLLVLC FNIGLICSQK TKPIGSKPIA VTTAAKTPAT STSPVTNGTG GPKFDLAALQ
     KLLATFQMMQ GAQGGNTAPS SSLPGVSSMP MPSANQISRK SNINANSLYQ PELMNTNVPY
     MGNSLQQSRF QNQFLGGQFA PNVNVYRTNN HISSFEQMRL TRSYNLDEEQ KFKILEEHNK
     FRSDVVQKRG TGAMNVLRWS EKLAAQASLE VMNCSYVNQG RGASLASVYE KYTGSSLVSE
     FMSRWSDEKN RFSLGENCSI QQTCRYSQAV WANTKQVGCA VQYCGDMSFI ACSYSPVGNT
     VNQIAFSPSR GGICSACTTP PNMPVRCNSD HLCEWY