SCP22_ARATH
ID SCP22_ARATH Reviewed; 464 AA.
AC Q1PF08; O82228; Q1PF09;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Serine carboxypeptidase-like 22;
DE EC=3.4.16.-;
DE Flags: Precursor;
GN Name=SCPL22; OrderedLocusNames=At2g24000; ORFNames=T29E15.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP GENE FAMILY, TISSUE SPECIFICITY, AND NOMENCLATURE.
RX PubMed=15908604; DOI=10.1104/pp.104.057950;
RA Fraser C.M., Rider L.W., Chapple C.;
RT "An expression and bioinformatics analysis of the Arabidopsis serine
RT carboxypeptidase-like gene family.";
RL Plant Physiol. 138:1136-1148(2005).
CC -!- FUNCTION: Probable carboxypeptidase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q1PF08-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q1PF08-2; Sequence=VSP_022849;
CC -!- TISSUE SPECIFICITY: Expression not detected.
CC {ECO:0000269|PubMed:15908604}.
CC -!- SIMILARITY: Belongs to the peptidase S10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC63668.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005170; AAC63668.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07515.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07516.1; -; Genomic_DNA.
DR EMBL; DQ446557; ABE65855.1; -; mRNA.
DR EMBL; DQ446558; ABE65856.1; -; mRNA.
DR PIR; D84631; D84631.
DR RefSeq; NP_001077950.1; NM_001084481.1. [Q1PF08-2]
DR RefSeq; NP_179978.2; NM_127962.3. [Q1PF08-1]
DR AlphaFoldDB; Q1PF08; -.
DR SMR; Q1PF08; -.
DR STRING; 3702.AT2G24000.1; -.
DR ESTHER; arath-SCP22; Carboxypeptidase_S10.
DR MEROPS; S10.A35; -.
DR PaxDb; Q1PF08; -.
DR PRIDE; Q1PF08; -.
DR ProteomicsDB; 226629; -. [Q1PF08-1]
DR EnsemblPlants; AT2G24000.1; AT2G24000.1; AT2G24000. [Q1PF08-1]
DR EnsemblPlants; AT2G24000.2; AT2G24000.2; AT2G24000. [Q1PF08-2]
DR GeneID; 816934; -.
DR Gramene; AT2G24000.1; AT2G24000.1; AT2G24000. [Q1PF08-1]
DR Gramene; AT2G24000.2; AT2G24000.2; AT2G24000. [Q1PF08-2]
DR KEGG; ath:AT2G24000; -.
DR Araport; AT2G24000; -.
DR TAIR; locus:2061436; AT2G24000.
DR eggNOG; KOG1282; Eukaryota.
DR HOGENOM; CLU_008523_13_0_1; -.
DR InParanoid; Q1PF08; -.
DR OMA; NFSWNTE; -.
DR PhylomeDB; Q1PF08; -.
DR PRO; PR:Q1PF08; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q1PF08; baseline and differential.
DR Genevisible; Q1PF08; AT.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004185; F:serine-type carboxypeptidase activity; IBA:GO_Central.
DR GO; GO:0009742; P:brassinosteroid mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001563; Peptidase_S10.
DR InterPro; IPR033124; Ser_caboxypep_his_AS.
DR InterPro; IPR018202; Ser_caboxypep_ser_AS.
DR PANTHER; PTHR11802; PTHR11802; 1.
DR Pfam; PF00450; Peptidase_S10; 1.
DR PRINTS; PR00724; CRBOXYPTASEC.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS00560; CARBOXYPEPT_SER_HIS; 1.
DR PROSITE; PS00131; CARBOXYPEPT_SER_SER; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Carboxypeptidase; Disulfide bond; Glycoprotein;
KW Hydrolase; Protease; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..464
FT /note="Serine carboxypeptidase-like 22"
FT /id="PRO_0000274638"
FT ACT_SITE 179
FT /evidence="ECO:0000250"
FT ACT_SITE 385
FT /evidence="ECO:0000250"
FT ACT_SITE 437
FT /evidence="ECO:0000250"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 290
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 335
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 86..346
FT /evidence="ECO:0000250"
FT DISULFID 247..258
FT /evidence="ECO:0000250"
FT DISULFID 282..314
FT /evidence="ECO:0000250"
FT VAR_SEQ 119..181
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17147637"
FT /id="VSP_022849"
SQ SEQUENCE 464 AA; 53106 MW; DFACB79F8A5BE6E4 CRC64;
MARTHLLFLL FVLLSLATSS TSTKEQEEDR IKALPGQPKV GFSQFSGYVT VNESHGRSLF
YWLTESSSHS PHTKPLLLWL NGGPGCSSIA YGASEEIGPF RISKTGCNLY LNNFSWNTEA
NLLFLESPVG VGFSYTNTSS DFEESGDERT AQENLIFLIS WMSRFPQYRY RDFYIVGESY
AGHYVPQLAQ KIHEYNNAYK NPVINLKGFM VGNPEMDKNN DRLGTITYWW SHAMISDASY
NRILKNCDFT ADRFSKECDS AIYVAAADFG DIDQYSIYTP KCVPPQDQTN QTKFEQMMQM
HTTKRFLEDQ YDPCTENYAE IYYNRPEVQR AMHANHTAIP YKWTACSDSV FNNWNWRDSD
NSMLPIYKEL IAAGLRIWVY SGDTDSVIPV TATRYSLGKL NLRVKTRWYP WYSGNQVGGR
TEVYEGLTFV TVRGAGHEVP FFQPQSALIL LRSFLAGNEL SRSY
