SCP2D_HUMAN
ID SCP2D_HUMAN Reviewed; 156 AA.
AC Q9UJQ7; Q548A4;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=SCP2 sterol-binding domain-containing protein 1;
GN Name=SCP2D1; Synonyms=C20orf79;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Guo J.H., She X.Y., Yu L.;
RT "Molecular cloning of a new cDNA encoding a protein containing a Pfam
RT domain.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AF418568; AAP97287.1; -; mRNA.
DR EMBL; AF418570; AAP97289.1; -; mRNA.
DR EMBL; AL035563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC105121; AAI05122.1; -; mRNA.
DR EMBL; BC112024; AAI12025.1; -; mRNA.
DR CCDS; CCDS13139.1; -.
DR RefSeq; NP_848578.1; NM_178483.2.
DR AlphaFoldDB; Q9UJQ7; -.
DR SMR; Q9UJQ7; -.
DR BioGRID; 126736; 2.
DR STRING; 9606.ENSP00000366645; -.
DR BioMuta; SCP2D1; -.
DR MassIVE; Q9UJQ7; -.
DR MaxQB; Q9UJQ7; -.
DR PaxDb; Q9UJQ7; -.
DR PeptideAtlas; Q9UJQ7; -.
DR PRIDE; Q9UJQ7; -.
DR Antibodypedia; 24632; 71 antibodies from 11 providers.
DR DNASU; 140856; -.
DR Ensembl; ENST00000377428.4; ENSP00000366645.2; ENSG00000132631.6.
DR GeneID; 140856; -.
DR KEGG; hsa:140856; -.
DR MANE-Select; ENST00000377428.4; ENSP00000366645.2; NM_178483.3; NP_848578.1.
DR UCSC; uc002wrk.4; human.
DR CTD; 140856; -.
DR GeneCards; SCP2D1; -.
DR HGNC; HGNC:16211; SCP2D1.
DR HPA; ENSG00000132631; Tissue enriched (testis).
DR neXtProt; NX_Q9UJQ7; -.
DR OpenTargets; ENSG00000132631; -.
DR PharmGKB; PA25788; -.
DR VEuPathDB; HostDB:ENSG00000132631; -.
DR eggNOG; KOG4170; Eukaryota.
DR GeneTree; ENSGT00940000154327; -.
DR HOGENOM; CLU_105945_3_1_1; -.
DR InParanoid; Q9UJQ7; -.
DR OMA; DTIFTIP; -.
DR OrthoDB; 1490913at2759; -.
DR PhylomeDB; Q9UJQ7; -.
DR TreeFam; TF343860; -.
DR PathwayCommons; Q9UJQ7; -.
DR BioGRID-ORCS; 140856; 12 hits in 1065 CRISPR screens.
DR GenomeRNAi; 140856; -.
DR Pharos; Q9UJQ7; Tdark.
DR PRO; PR:Q9UJQ7; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9UJQ7; protein.
DR Bgee; ENSG00000132631; Expressed in left testis and 28 other tissues.
DR Genevisible; Q9UJQ7; HS.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0015914; P:phospholipid transport; IBA:GO_Central.
DR GO; GO:0032385; P:positive regulation of intracellular cholesterol transport; IBA:GO_Central.
DR GO; GO:0006694; P:steroid biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.30.1050.10; -; 1.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR Pfam; PF02036; SCP2; 1.
DR SUPFAM; SSF55718; SSF55718; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..156
FT /note="SCP2 sterol-binding domain-containing protein 1"
FT /id="PRO_0000079444"
FT DOMAIN 44..156
FT /note="SCP2"
FT VARIANT 99
FT /note="P -> S (in dbSNP:rs1053839)"
FT /id="VAR_024332"
SQ SEQUENCE 156 AA; 17663 MW; CBFC914EC6FCADF6 CRC64;
MWKRSDHQPK IKAEDGPLVG QFEVLGSVPE PAMPHPLELS EFESFPVFQD IRLHIREVGA
QLVKKVNAVF QLDITKNGKT ILRWTIDLKN GSGDMYPGPA RLPADTVFTI PESVFMELVL
GKMNPQKAFL AGKFKVSGKV LLSWKLERVF KDWAKF
