SCP2D_MOUSE
ID SCP2D_MOUSE Reviewed; 156 AA.
AC Q9DAH1; Q5RL24;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=SCP2 sterol-binding domain-containing protein 1;
GN Name=Scp2d1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB24272.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK005847; BAB24272.2; ALT_INIT; mRNA.
DR EMBL; AL808106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC048653; AAH48653.1; -; mRNA.
DR CCDS; CCDS38255.1; -.
DR RefSeq; NP_079766.3; NM_025490.2.
DR AlphaFoldDB; Q9DAH1; -.
DR SMR; Q9DAH1; -.
DR STRING; 10090.ENSMUSP00000028918; -.
DR PaxDb; Q9DAH1; -.
DR PRIDE; Q9DAH1; -.
DR ProteomicsDB; 256756; -.
DR Antibodypedia; 24632; 71 antibodies from 11 providers.
DR DNASU; 66328; -.
DR Ensembl; ENSMUST00000028918; ENSMUSP00000028918; ENSMUSG00000027431.
DR GeneID; 66328; -.
DR KEGG; mmu:66328; -.
DR UCSC; uc008mrp.1; mouse.
DR CTD; 140856; -.
DR MGI; MGI:1913578; Scp2d1.
DR VEuPathDB; HostDB:ENSMUSG00000027431; -.
DR eggNOG; KOG4170; Eukaryota.
DR GeneTree; ENSGT00940000154327; -.
DR HOGENOM; CLU_105945_3_1_1; -.
DR InParanoid; Q9DAH1; -.
DR OMA; DTIFTIP; -.
DR OrthoDB; 1490913at2759; -.
DR PhylomeDB; Q9DAH1; -.
DR TreeFam; TF343860; -.
DR BioGRID-ORCS; 66328; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q9DAH1; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9DAH1; protein.
DR Bgee; ENSMUSG00000027431; Expressed in spermatid and 4 other tissues.
DR Genevisible; Q9DAH1; MM.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0015914; P:phospholipid transport; IBA:GO_Central.
DR GO; GO:0032385; P:positive regulation of intracellular cholesterol transport; IBA:GO_Central.
DR GO; GO:0006694; P:steroid biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.30.1050.10; -; 1.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR Pfam; PF02036; SCP2; 1.
DR SUPFAM; SSF55718; SSF55718; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..156
FT /note="SCP2 sterol-binding domain-containing protein 1"
FT /id="PRO_0000079445"
FT DOMAIN 44..156
FT /note="SCP2"
FT CONFLICT 9
FT /note="A -> V (in Ref. 1; BAB24272)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 156 AA; 17371 MW; 1DBE7FFD80C99568 CRC64;
MWKRPDPQAK IKAGDRPQTC QSLALGSATE SALPQALKLS DFQNFSVFED ISQHIKEVGA
QLVKKVNAIF QLDITKDGKT ILQWTIDLKN GAGDMYLGSA RLPADTVFII PDSVFTELVV
GKINPQKAFL AGKFKVRGKV LLSQKLERIF REWAKI
