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ABD18_HUMAN
ID   ABD18_HUMAN             Reviewed;         414 AA.
AC   Q0P651; A1A4W8; A1A4W9; Q9H7A7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Protein ABHD18 {ECO:0000305};
DE   AltName: Full=Alpha/beta hydrolase domain-containing protein 18 {ECO:0000305};
DE            Short=Abhydrolase domain-containing protein 18 {ECO:0000312|HGNC:HGNC:26111};
DE   Flags: Precursor;
GN   Name=ABHD18 {ECO:0000312|HGNC:HGNC:26111}; Synonyms=C4orf29;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC   TISSUE=Coronary artery;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC   TISSUE=Lymph;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q0P651-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q0P651-2; Sequence=VSP_027893;
CC       Name=3;
CC         IsoId=Q0P651-3; Sequence=VSP_027892, VSP_027894;
CC       Name=4;
CC         IsoId=Q0P651-4; Sequence=VSP_027891, VSP_027894;
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR   EMBL; AK024759; BAB14990.1; -; mRNA.
DR   EMBL; BC034253; AAH34253.1; -; mRNA.
DR   EMBL; BC128142; AAI28143.1; -; mRNA.
DR   EMBL; BC128143; AAI28144.1; -; mRNA.
DR   AlphaFoldDB; Q0P651; -.
DR   BioGRID; 123153; 34.
DR   IntAct; Q0P651; 15.
DR   STRING; 9606.ENSP00000381937; -.
DR   ESTHER; human-ABHD18; ABHD18.
DR   GlyGen; Q0P651; 2 sites.
DR   iPTMnet; Q0P651; -.
DR   PhosphoSitePlus; Q0P651; -.
DR   BioMuta; ABHD18; -.
DR   DMDM; 121940364; -.
DR   EPD; Q0P651; -.
DR   jPOST; Q0P651; -.
DR   MassIVE; Q0P651; -.
DR   MaxQB; Q0P651; -.
DR   PaxDb; Q0P651; -.
DR   PeptideAtlas; Q0P651; -.
DR   PRIDE; Q0P651; -.
DR   ProteomicsDB; 58769; -. [Q0P651-1]
DR   ProteomicsDB; 58770; -. [Q0P651-2]
DR   ProteomicsDB; 58771; -. [Q0P651-3]
DR   ProteomicsDB; 58772; -. [Q0P651-4]
DR   Antibodypedia; 64973; 86 antibodies from 17 providers.
DR   Ensembl; ENST00000398965.5; ENSP00000381937.1; ENSG00000164074.16. [Q0P651-1]
DR   Ensembl; ENST00000444616.5; ENSP00000397229.1; ENSG00000164074.16. [Q0P651-1]
DR   Ensembl; ENST00000611882.1; ENSP00000480015.1; ENSG00000164074.16. [Q0P651-3]
DR   UCSC; uc021xrt.2; human. [Q0P651-1]
DR   GeneCards; ABHD18; -.
DR   HGNC; HGNC:26111; ABHD18.
DR   HPA; ENSG00000164074; Low tissue specificity.
DR   neXtProt; NX_Q0P651; -.
DR   OpenTargets; ENSG00000164074; -.
DR   PharmGKB; PA147358673; -.
DR   VEuPathDB; HostDB:ENSG00000164074; -.
DR   eggNOG; KOG1551; Eukaryota.
DR   GeneTree; ENSGT00390000014635; -.
DR   HOGENOM; CLU_035640_0_0_1; -.
DR   InParanoid; Q0P651; -.
DR   OMA; LLNWCEQ; -.
DR   OrthoDB; 1294532at2759; -.
DR   PhylomeDB; Q0P651; -.
DR   TreeFam; TF314683; -.
DR   PathwayCommons; Q0P651; -.
DR   SignaLink; Q0P651; -.
DR   ChiTaRS; ABHD18; human.
DR   Pharos; Q0P651; Tdark.
DR   PRO; PR:Q0P651; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q0P651; protein.
DR   Bgee; ENSG00000164074; Expressed in buccal mucosa cell and 187 other tissues.
DR   ExpressionAtlas; Q0P651; baseline and differential.
DR   Genevisible; Q0P651; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR019149; ABHD18.
DR   PANTHER; PTHR13617; PTHR13617; 1.
DR   Pfam; PF09752; DUF2048; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..414
FT                   /note="Protein ABHD18"
FT                   /id="PRO_0000301960"
FT   CARBOHYD        282
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        307
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..203
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_027891"
FT   VAR_SEQ         1..127
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_027892"
FT   VAR_SEQ         1..94
FT                   /note="MGVSKLDILYRRLLLTKLFIRGWGRPEDLKRLFEFRKMIGNRERCQNLVSSD
FT                   YPVHIDKIEEQSDCKILDGHFVSPMAHYVPDIMPIESVIARF -> MLDTNLILLPLF
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_027893"
FT   VAR_SEQ         233
FT                   /note="T -> TGVLSKSINWRELEKQYYTQTVYEEEIIHMLEYCG (in isoform
FT                   3 and isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_027894"
FT   CONFLICT        Q0P651-4:36
FT                   /note="S -> P (in Ref. 1; BAB14990)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   414 AA;  46954 MW;  D62F491F23A02D4C CRC64;
     MGVSKLDILY RRLLLTKLFI RGWGRPEDLK RLFEFRKMIG NRERCQNLVS SDYPVHIDKI
     EEQSDCKILD GHFVSPMAHY VPDIMPIESV IARFQFIVPK EWNSKYRPVC IHLAGTGDHH
     YWRRRTLMAR PMIKEARMAS LLLENPYYGC RKPKDQVRSS LKNVSDLFVM GGALVLESAA
     LLHWLEREGY GPLGMTGISM GGHMASLAVS NWPKPMPLIP CLSWSTASGV FTTTDSFKMG
     QEFVKHFTSS ADKLTNLNLV SRTLNLDISN QVVSQKPADC HNSSKTSVSA TSEGLLLQDT
     SKMKRFNQTL STNKSGYTSR NPQSYHLLSK EQSRNSLRKE SLIFMKGVMD ECTHVANFSV
     PVDPSLIIVV QAKEDAYIPR TGVRSLQEIW PGCEIRYLEG GHISAYLFKQ GLFR
 
 
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