ID   SCP41_VERDV             Reviewed;         336 AA.
AC   G2XDH0;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Effector SCP41 {ECO:0000303|PubMed:29757140};
DE   AltName: Full=Cysteine-containing protein 41 {ECO:0000303|PubMed:29757140};
DE   AltName: Full=VdSCP41 {ECO:0000303|PubMed:29757140};
DE   Flags: Precursor;
GN   Name=SCP41 {ECO:0000303|PubMed:29757140};
GN   ORFNames=VDAG_08202 {ECO:0000312|EMBL:EGY17038.1};
OS   Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS   (Verticillium wilt).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=498257 {ECO:0000312|Proteomes:UP000001611};
RN   [1] {ECO:0000312|Proteomes:UP000001611}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VdLs.17 / ATCC MYA-4575 / FGSC 10137
RC   {ECO:0000312|Proteomes:UP000001611};
RX   PubMed=21829347; DOI=10.1371/journal.ppat.1002137;
RA   Klosterman S.J., Subbarao K.V., Kang S., Veronese P., Gold S.E.,
RA   Thomma B.P.H.J., Chen Z., Henrissat B., Lee Y.-H., Park J.,
RA   Garcia-Pedrajas M.D., Barbara D.J., Anchieta A., de Jonge R., Santhanam P.,
RA   Maruthachalam K., Atallah Z., Amyotte S.G., Paz Z., Inderbitzin P.,
RA   Hayes R.J., Heiman D.I., Young S., Zeng Q., Engels R., Galagan J.,
RA   Cuomo C.A., Dobinson K.F., Ma L.-J.;
RT   "Comparative genomics yields insights into niche adaptation of plant
RT   vascular wilt pathogens.";
RL   PLoS Pathog. 7:E1002137-E1002137(2011).
RN   [2] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH A.THALIANA CBP60G AND SARD1, SUBCELLULAR
RP   LOCATION, INDUCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF
RP   52-ARG--PHE-60.
RX   PubMed=29757140; DOI=10.7554/elife.34902;
RA   Qin J., Wang K., Sun L., Xing H., Wang S., Li L., Chen S., Guo H.S.,
RA   Zhang J.;
RT   "The plant-specific transcription factors CBP60g and SARD1 are targeted by
RT   a Verticillium secretory protein VdSCP41 to modulate immunity.";
RL   Elife 7:e34902-e34902(2018).
CC   -!- FUNCTION: Effector that binds transcription regulators in the host
CC       plant to suppress the host's innate immune response (PubMed:29757140).
CC       Inhibits the host plant transcription regulators CBP60G and SARD1
CC       (PubMed:29757140). {ECO:0000269|PubMed:29757140}.
CC   -!- SUBUNIT: Interacts with A.thaliana CBP60G; the interaction is direct
CC       (PubMed:29757140). Interacts with A.thaliana SARD1 (PubMed:29757140).
CC       Interacts with G.hirsutum CBP60B (PubMed:29757140).
CC       {ECO:0000269|PubMed:29757140}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29757140}. Host
CC       nucleus {ECO:0000269|PubMed:29757140}.
CC   -!- INDUCTION: Expression is induced by plant roots.
CC       {ECO:0000269|PubMed:29757140}.
CC   -!- DISRUPTION PHENOTYPE: Decreases virulence in A.thaliana and G.hirsutum.
CC       {ECO:0000269|PubMed:29757140}.
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DR   EMBL; DS572713; EGY17038.1; -; Genomic_DNA.
DR   RefSeq; XP_009655874.1; XM_009657579.1.
DR   EnsemblFungi; EGY17038; EGY17038; VDAG_08202.
DR   GeneID; 20709665; -.
DR   KEGG; vda:VDAG_08202; -.
DR   eggNOG; ENOG502T4K5; Eukaryota.
DR   HOGENOM; CLU_083378_0_0_1; -.
DR   InParanoid; G2XDH0; -.
DR   OMA; CVCLNKS; -.
DR   Proteomes; UP000001611; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0042025; C:host cell nucleus; IDA:UniProtKB.
DR   GO; GO:0140416; F:transcription regulator inhibitor activity; IPI:UniProtKB.
DR   GO; GO:0140403; P:effector-mediated suppression of host innate immune response; IMP:UniProtKB.
PE   1: Evidence at protein level;
KW   Host nucleus; Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..336
FT                   /note="Effector SCP41"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5003439752"
FT   REGION          59..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          189..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         52..60
FT                   /note="Missing: Abolishes nuclear localization in host
FT                   cell."
FT                   /evidence="ECO:0000269|PubMed:29757140"
SQ   SEQUENCE   336 AA;  35174 MW;  A08EDEC8027A9B2C CRC64;
     MRTETASLLL LAALSVAEEL TPNDVPLACA NMCGPIVELS YKCDVDGTDE LRKLKRRKLF
     SPQQQQQQQQ QQQQSAPKAK RQADPEPQAP APVPSSTNNQ QAADVIFIPG SIGKFKTIPT
     PLPPADTGVP SMAVTPAAPA PTLPVLDLRP TTTPTNLNPN LPILATPILP SVPASTPLAT
     ASSTQVPLPV GNEADAGDGV DAGPAPSNSL NGNVGDMVDD AGNLWPGQKG RQAASDLETA
     CICSNTSFNV RRVAGLCGDC LEQVSGDQGP MRAILASCNF TTERYEPEKE SLVANVRVEA
     TKPSFTQTAA ASYSWRVSGP TWAVVVGAGM LLGMGW