SCP43_ARATH
ID SCP43_ARATH Reviewed; 442 AA.
AC Q84W27; Q9SHU3;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Serine carboxypeptidase-like 43;
DE EC=3.4.16.-;
DE Flags: Precursor;
GN Name=SCPL43; OrderedLocusNames=At2g12480; ORFNames=T27D6.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, TISSUE SPECIFICITY, AND NOMENCLATURE.
RX PubMed=15908604; DOI=10.1104/pp.104.057950;
RA Fraser C.M., Rider L.W., Chapple C.;
RT "An expression and bioinformatics analysis of the Arabidopsis serine
RT carboxypeptidase-like gene family.";
RL Plant Physiol. 138:1136-1148(2005).
CC -!- FUNCTION: Probable carboxypeptidase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q84W27-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expression not detected.
CC {ECO:0000269|PubMed:15908604}.
CC -!- SIMILARITY: Belongs to the peptidase S10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD28662.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007268; AAD28662.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC06202.1; -; Genomic_DNA.
DR EMBL; BT004306; AAO42304.1; -; mRNA.
DR PIR; D84503; D84503.
DR RefSeq; NP_001323740.1; NM_001335380.1.
DR RefSeq; NP_178937.2; NM_126893.4. [Q84W27-1]
DR AlphaFoldDB; Q84W27; -.
DR SMR; Q84W27; -.
DR ESTHER; arath-AT2G12480; Carboxypeptidase_S10.
DR MEROPS; S10.A33; -.
DR PaxDb; Q84W27; -.
DR PRIDE; Q84W27; -.
DR ProteomicsDB; 232920; -. [Q84W27-1]
DR EnsemblPlants; AT2G12480.1; AT2G12480.1; AT2G12480. [Q84W27-1]
DR GeneID; 815721; -.
DR Gramene; AT2G12480.1; AT2G12480.1; AT2G12480. [Q84W27-1]
DR KEGG; ath:AT2G12480; -.
DR Araport; AT2G12480; -.
DR eggNOG; KOG1282; Eukaryota.
DR HOGENOM; CLU_008523_13_1_1; -.
DR InParanoid; Q84W27; -.
DR OrthoDB; 625787at2759; -.
DR PhylomeDB; Q84W27; -.
DR PRO; PR:Q84W27; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q84W27; baseline and differential.
DR Genevisible; Q84W27; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004185; F:serine-type carboxypeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001563; Peptidase_S10.
DR InterPro; IPR018202; Ser_caboxypep_ser_AS.
DR PANTHER; PTHR11802; PTHR11802; 1.
DR Pfam; PF00450; Peptidase_S10; 1.
DR PRINTS; PR00724; CRBOXYPTASEC.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS00131; CARBOXYPEPT_SER_SER; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Carboxypeptidase; Disulfide bond; Glycoprotein;
KW Hydrolase; Protease; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..442
FT /note="Serine carboxypeptidase-like 43"
FT /id="PRO_0000274658"
FT ACT_SITE 178
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10074"
FT ACT_SITE 350
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10074"
FT ACT_SITE 407
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10074"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 253
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 302
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 318
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 86..313
FT /evidence="ECO:0000250"
FT DISULFID 246..258
FT /evidence="ECO:0000255"
SQ SEQUENCE 442 AA; 49774 MW; 787C9B71A2D50294 CRC64;
MVSSRAVVMA IMVLVTVQWL VFAEGYPEED LVARLPGQPN VGFRQFAGYV DVDSENGRSL
FYYYVEAVKE PDTKPLTLWL NGGPGCSSVG GGAFTELGPF YPTGDGRGLR LNSMSWNKAS
NLLFVESPAG VGWSYSNRSS DYNTGDKSTV NDMLVFLLRW FNKFPELKSR DLFLTGESYA
GHYIPQLADV ILSYNSRSSG FKFNVKGIAI GNPLLKLDRD FAAAYEYFWS HGMISDEVRL
TIMNQCDFAN PKNMSNACIY AIVESSVLTE YINSYHILLD VCYPSIVQQE LRLKKMNALH
ANRTRLPYEW TMCSNRLNYS GIDGYIDMLP SLKRIIQNQT PVWIFSGDQD SVIPLQSSRT
LVRELAEDLN FKTTIPYGAW FHKEQVGGWV TEYGNLLTFA TVRGAAHMVP YAEPSRALHM
FSSFMNGRRL PNKPDLKSST DD
