SCP46_ARATH
ID SCP46_ARATH Reviewed; 465 AA.
AC Q8VY01; O22803;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Serine carboxypeptidase-like 46;
DE EC=3.4.16.-;
DE Flags: Precursor;
GN Name=SCPL46; OrderedLocusNames=At2g33530; ORFNames=F4P9.30;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, TISSUE SPECIFICITY, AND NOMENCLATURE.
RX PubMed=15908604; DOI=10.1104/pp.104.057950;
RA Fraser C.M., Rider L.W., Chapple C.;
RT "An expression and bioinformatics analysis of the Arabidopsis serine
RT carboxypeptidase-like gene family.";
RL Plant Physiol. 138:1136-1148(2005).
CC -!- FUNCTION: Probable carboxypeptidase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:15908604}.
CC -!- SIMILARITY: Belongs to the peptidase S10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB80670.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002332; AAB80670.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC08849.1; -; Genomic_DNA.
DR EMBL; AY074317; AAL67013.1; -; mRNA.
DR PIR; F84746; F84746.
DR RefSeq; NP_850212.1; NM_179881.4.
DR AlphaFoldDB; Q8VY01; -.
DR SMR; Q8VY01; -.
DR STRING; 3702.AT2G33530.1; -.
DR ESTHER; arath-SCP46; Carboxypeptidase_S10.
DR MEROPS; S10.A42; -.
DR PaxDb; Q8VY01; -.
DR PRIDE; Q8VY01; -.
DR ProteomicsDB; 232713; -.
DR EnsemblPlants; AT2G33530.1; AT2G33530.1; AT2G33530.
DR GeneID; 817918; -.
DR Gramene; AT2G33530.1; AT2G33530.1; AT2G33530.
DR KEGG; ath:AT2G33530; -.
DR Araport; AT2G33530; -.
DR TAIR; locus:2051149; AT2G33530.
DR eggNOG; KOG1282; Eukaryota.
DR HOGENOM; CLU_008523_13_1_1; -.
DR InParanoid; Q8VY01; -.
DR OMA; YMGANDS; -.
DR OrthoDB; 607679at2759; -.
DR PhylomeDB; Q8VY01; -.
DR PRO; PR:Q8VY01; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8VY01; baseline and differential.
DR Genevisible; Q8VY01; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:TAIR.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0009505; C:plant-type cell wall; HDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0004185; F:serine-type carboxypeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001563; Peptidase_S10.
DR InterPro; IPR018202; Ser_caboxypep_ser_AS.
DR PANTHER; PTHR11802; PTHR11802; 1.
DR Pfam; PF00450; Peptidase_S10; 1.
DR PRINTS; PR00724; CRBOXYPTASEC.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS00131; CARBOXYPEPT_SER_SER; 1.
PE 2: Evidence at transcript level;
KW Carboxypeptidase; Disulfide bond; Glycoprotein; Hydrolase; Protease;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..465
FT /note="Serine carboxypeptidase-like 46"
FT /id="PRO_0000274661"
FT ACT_SITE 179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10074"
FT ACT_SITE 381
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10074"
FT ACT_SITE 438
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10074"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 246
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 88..344
FT /evidence="ECO:0000250"
FT DISULFID 245..263
FT /evidence="ECO:0000250"
FT DISULFID 288..313
FT /evidence="ECO:0000250"
SQ SEQUENCE 465 AA; 51883 MW; 0114434EFC12AFEA CRC64;
MPRLQCLTMA TSLILLLQAL SLVSSTILSR ADRITRLPGQ PRVGFQQYSG YVTIDEKKQR
ALFYYLAEAE TKPISKPLVL WLNGGPGCSS LGVGAFSENG PFRPKGSILV RNQHSWNQEA
NMLYLETPVG VGFSYANESS SYEGVNDKIT AKDNLVFLQK WFLKFPQYLN RSLFITGESY
AGHYVPQLAQ LMIQYNKKHN LFNLKGIAIG NPVMEFATDF NSRAEYFWSH GLISDPTYKL
FTSSCNYSRF LSEYHRGSVS SMCTKVLSQV GIETSRFIDK YDVTLDVCIP SVLSQSKVVS
PQPQQVGETV DVCLEDETVN YLNRRDVQKA LHARLVGTRK WTVCSDVLDY EVLDVEVPTI
NIVGSLVKAG VPVFVYSGDQ DSVIPLTGSR TLVKRLAEEL GLRTTVPYRV WFAGQQVGGW
TQVYGNTLAF ATVRGAAHEV PFSQPARALV LFKAFLGGRP LPEEF
