SCP48_ARATH
ID SCP48_ARATH Reviewed; 510 AA.
AC Q56WF8; Q93ZC3; Q9LXH4;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Serine carboxypeptidase-like 48;
DE EC=3.4.16.-;
DE Flags: Precursor;
GN Name=SCPL48; OrderedLocusNames=At3g45010; ORFNames=F14D17.80;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 330-510.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, TISSUE SPECIFICITY, AND NOMENCLATURE.
RX PubMed=15908604; DOI=10.1104/pp.104.057950;
RA Fraser C.M., Rider L.W., Chapple C.;
RT "An expression and bioinformatics analysis of the Arabidopsis serine
RT carboxypeptidase-like gene family.";
RL Plant Physiol. 138:1136-1148(2005).
CC -!- FUNCTION: Probable carboxypeptidase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:15908604}.
CC -!- SIMILARITY: Belongs to the peptidase S10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD94954.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL353992; CAB89316.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77979.1; -; Genomic_DNA.
DR EMBL; AY050427; AAK91443.1; -; mRNA.
DR EMBL; AY057639; AAL15270.1; -; mRNA.
DR EMBL; AY093993; AAM16254.1; -; mRNA.
DR EMBL; AK222084; BAD94954.1; ALT_INIT; mRNA.
DR PIR; T48977; T48977.
DR RefSeq; NP_190087.1; NM_114370.4.
DR AlphaFoldDB; Q56WF8; -.
DR SMR; Q56WF8; -.
DR STRING; 3702.AT3G45010.1; -.
DR ChEMBL; CHEMBL1932908; -.
DR ESTHER; arath-F14D17.80; Carboxypeptidase_S10.
DR MEROPS; S10.A46; -.
DR PaxDb; Q56WF8; -.
DR PRIDE; Q56WF8; -.
DR ProteomicsDB; 226605; -.
DR EnsemblPlants; AT3G45010.1; AT3G45010.1; AT3G45010.
DR GeneID; 823636; -.
DR Gramene; AT3G45010.1; AT3G45010.1; AT3G45010.
DR KEGG; ath:AT3G45010; -.
DR Araport; AT3G45010; -.
DR TAIR; locus:2075929; AT3G45010.
DR eggNOG; KOG1282; Eukaryota.
DR HOGENOM; CLU_008523_10_1_1; -.
DR InParanoid; Q56WF8; -.
DR OMA; NCYVEMD; -.
DR OrthoDB; 625787at2759; -.
DR PhylomeDB; Q56WF8; -.
DR PRO; PR:Q56WF8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q56WF8; baseline and differential.
DR Genevisible; Q56WF8; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR GO; GO:0004185; F:serine-type carboxypeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001563; Peptidase_S10.
DR InterPro; IPR033124; Ser_caboxypep_his_AS.
DR InterPro; IPR018202; Ser_caboxypep_ser_AS.
DR PANTHER; PTHR11802; PTHR11802; 1.
DR Pfam; PF00450; Peptidase_S10; 1.
DR PRINTS; PR00724; CRBOXYPTASEC.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS00560; CARBOXYPEPT_SER_HIS; 1.
DR PROSITE; PS00131; CARBOXYPEPT_SER_SER; 1.
PE 2: Evidence at transcript level;
KW Carboxypeptidase; Disulfide bond; Glycoprotein; Hydrolase; Protease;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..510
FT /note="Serine carboxypeptidase-like 48"
FT /id="PRO_0000274663"
FT ACT_SITE 231
FT /evidence="ECO:0000250"
FT ACT_SITE 421
FT /evidence="ECO:0000250"
FT ACT_SITE 478
FT /evidence="ECO:0000250"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 141..383
FT /evidence="ECO:0000250"
FT DISULFID 309..326
FT /evidence="ECO:0000250"
FT DISULFID 349..354
FT /evidence="ECO:0000250"
FT CONFLICT 455
FT /note="D -> G (in Ref. 3; AAL15270)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 510 AA; 56896 MW; 134BC30F4E64BF0A CRC64;
MDSKTTFLTF LLCIFIFSHF SPSTSKSLTE KPLSFSPSAS LPTLTAERLI KGFNLMPTRD
VNVIDEEGSE APRLVERAFD LPAAVDRRGS GGSPSVQDFG HHAGYYKLPN SKAARMFYFF
FESRTNKADP VVIWLTGGPG CSSELALFYE NGPFTVSNNS SLSWNEFGWD KASNLIYVDQ
PVGTGFSYTS DQSDLRHDED GVSNDLYDFL QAFFKEHPQF VKNDFYITGE SYAGHYIPAL
ASRVHRGNKN KEGTHINLKG FAIGNGLTNP EIQYGAYADY ALDMNLITQS DHDNLNRYYA
TCQQSIKECS ADGGEGDACA SSYTVCNNIF QKIMDIAGNV NYYDVRKQCE GSLCYDFSNM
ENFLNQKSVR KALGVGDIEF VSCSTAVYEA MQMDWMRNLE VGIPALLQDG IKLLVYAGEY
DLICNWLGNS KWVHEMEWSG QKEFVAAATV PFHVDNKEAG LMKNYGSLTF LKVHDAGHMV
PMDQPKAALQ MLQNWMQGKL STPTGRTAHQ
