ID   SCPA_CLOPE              Reviewed;         248 AA.
AC   Q8XJF4;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Segregation and condensation protein A {ECO:0000255|HAMAP-Rule:MF_01805};
GN   Name=scpA {ECO:0000255|HAMAP-Rule:MF_01805}; OrderedLocusNames=CPE1805;
OS   Clostridium perfringens (strain 13 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=13 / Type A;
RX   PubMed=11792842; DOI=10.1073/pnas.022493799;
RA   Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T.,
RA   Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT   "Complete genome sequence of Clostridium perfringens, an anaerobic flesh-
RT   eater.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
CC   -!- FUNCTION: Participates in chromosomal partition during cell division.
CC       May act via the formation of a condensin-like complex containing Smc
CC       and ScpB that pull DNA away from mid-cell into both cell halves.
CC       {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC       the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC       Smc. The presence of the three proteins is required for the association
CC       of the complex with DNA. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01805}.
CC       Note=Associated with two foci at the outer edges of the nucleoid region
CC       in young cells, and at four foci within both cell halves in older
CC       cells. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01805}.
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DR   EMBL; BA000016; BAB81511.1; -; Genomic_DNA.
DR   RefSeq; WP_003458723.1; NC_003366.1.
DR   AlphaFoldDB; Q8XJF4; -.
DR   SMR; Q8XJF4; -.
DR   STRING; 195102.gene:10491069; -.
DR   EnsemblBacteria; BAB81511; BAB81511; BAB81511.
DR   GeneID; 29570838; -.
DR   KEGG; cpe:CPE1805; -.
DR   HOGENOM; CLU_038686_3_0_9; -.
DR   OMA; YLVMAAM; -.
DR   Proteomes; UP000000818; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.580; -; 1.
DR   HAMAP; MF_01805; ScpA; 1.
DR   InterPro; IPR003768; ScpA.
DR   InterPro; IPR023093; ScpA-like_C.
DR   PANTHER; PTHR33969; PTHR33969; 1.
DR   Pfam; PF02616; SMC_ScpA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW   Reference proteome.
FT   CHAIN           1..248
FT                   /note="Segregation and condensation protein A"
FT                   /id="PRO_0000211082"
SQ   SEQUENCE   248 AA;  29442 MW;  2107D18856914EDD CRC64;
     MEMPIIKLKN FDGPFDLLLH LIKKNEMSIT EIKIHEITKQ YLEYIALMKE LDLEITSEFI
     VMAATLIEIK SKSLLPKVKV EDETCEEDLQ KILMEKLQEY KKFKKISAYL RERELSTGEV
     FTKKAEIIEV EVDNKLDDDY FKNITMLDLY KLYNNLMRIY GEKQNVNVME KKISVDKYKI
     TDKINFLRDK LSEKSIVRFS EFIPQCECKL EVVVTFMAML ELIKRSEIKV VQYENFGEIM
     MEKVIVNE