SCPA_CLOTE
ID SCPA_CLOTE Reviewed; 254 AA.
AC Q894L2;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Segregation and condensation protein A {ECO:0000255|HAMAP-Rule:MF_01805};
GN Name=scpA {ECO:0000255|HAMAP-Rule:MF_01805}; OrderedLocusNames=CTC_01529;
OS Clostridium tetani (strain Massachusetts / E88).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=212717;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Massachusetts / E88;
RX PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA Gottschalk G.;
RT "The genome sequence of Clostridium tetani, the causative agent of tetanus
RT disease.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC -!- FUNCTION: Participates in chromosomal partition during cell division.
CC May act via the formation of a condensin-like complex containing Smc
CC and ScpB that pull DNA away from mid-cell into both cell halves.
CC {ECO:0000255|HAMAP-Rule:MF_01805}.
CC -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC Smc. The presence of the three proteins is required for the association
CC of the complex with DNA. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01805}.
CC Note=Associated with two foci at the outer edges of the nucleoid region
CC in young cells, and at four foci within both cell halves in older
CC cells. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000255|HAMAP-
CC Rule:MF_01805}.
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DR EMBL; AE015927; AAO36080.1; -; Genomic_DNA.
DR RefSeq; WP_011099740.1; NC_004557.1.
DR AlphaFoldDB; Q894L2; -.
DR SMR; Q894L2; -.
DR STRING; 212717.CTC_01529; -.
DR EnsemblBacteria; AAO36080; AAO36080; CTC_01529.
DR GeneID; 64180777; -.
DR KEGG; ctc:CTC_01529; -.
DR HOGENOM; CLU_038686_3_0_9; -.
DR OMA; YLVMAAM; -.
DR OrthoDB; 959677at2; -.
DR Proteomes; UP000001412; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.580; -; 1.
DR HAMAP; MF_01805; ScpA; 1.
DR InterPro; IPR003768; ScpA.
DR InterPro; IPR023093; ScpA-like_C.
DR PANTHER; PTHR33969; PTHR33969; 1.
DR Pfam; PF02616; SMC_ScpA; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW Reference proteome.
FT CHAIN 1..254
FT /note="Segregation and condensation protein A"
FT /id="PRO_0000211083"
SQ SEQUENCE 254 AA; 30076 MW; 65FECE41399DC733 CRC64;
MELQIKIQNF QGPFDLLLHL IKKNQLDIYN INISEITGQY MEYIESLKEM DLEVTSEFIV
IASTLLQIKS RELLPKIQDE EEEEISEENP EKILLDKLIE YKKFKNVASY LKGRLEKGFT
VFSKKPEIIE KKEEEDKDIF IDVTILELYN LYNELITKYK DKINLSNTIP EEIELEEFKI
GDKMNYLKSR IIENKNLSFS QISKECSCKG EVIVTFLALL ELIRIKIVKV VQEGNFKEIY
LERMEENEAD ELYY