SCPA_COXBU
ID SCPA_COXBU Reviewed; 266 AA.
AC Q83CP8;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Segregation and condensation protein A {ECO:0000255|HAMAP-Rule:MF_01805};
GN Name=scpA {ECO:0000255|HAMAP-Rule:MF_01805}; OrderedLocusNames=CBU_1061;
OS Coxiella burnetii (strain RSA 493 / Nine Mile phase I).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC Coxiella.
OX NCBI_TaxID=227377;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RSA 493 / Nine Mile phase I;
RX PubMed=12704232; DOI=10.1073/pnas.0931379100;
RA Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C.,
RA Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T.,
RA Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M.,
RA Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E.,
RA Fraser C.M., Heidelberg J.F.;
RT "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).
CC -!- FUNCTION: Participates in chromosomal partition during cell division.
CC May act via the formation of a condensin-like complex containing Smc
CC and ScpB that pull DNA away from mid-cell into both cell halves.
CC {ECO:0000255|HAMAP-Rule:MF_01805}.
CC -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC Smc. The presence of the three proteins is required for the association
CC of the complex with DNA. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01805}.
CC Note=Associated with two foci at the outer edges of the nucleoid region
CC in young cells, and at four foci within both cell halves in older
CC cells. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000255|HAMAP-
CC Rule:MF_01805}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO90575.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE016828; AAO90575.2; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_820061.2; NC_002971.3.
DR AlphaFoldDB; Q83CP8; -.
DR SMR; Q83CP8; -.
DR STRING; 227377.CBU_1061; -.
DR EnsemblBacteria; AAO90575; AAO90575; CBU_1061.
DR GeneID; 1208962; -.
DR KEGG; cbu:CBU_1061; -.
DR PATRIC; fig|227377.7.peg.1052; -.
DR eggNOG; COG1354; Bacteria.
DR HOGENOM; CLU_038686_0_1_6; -.
DR OMA; YLVMAAM; -.
DR Proteomes; UP000002671; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.580; -; 1.
DR HAMAP; MF_01805; ScpA; 1.
DR InterPro; IPR003768; ScpA.
DR InterPro; IPR023093; ScpA-like_C.
DR PANTHER; PTHR33969; PTHR33969; 1.
DR Pfam; PF02616; SMC_ScpA; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW Reference proteome.
FT CHAIN 1..266
FT /note="Segregation and condensation protein A"
FT /id="PRO_0000244642"
SQ SEQUENCE 266 AA; 30441 MW; 81CB160010E28A0A CRC64;
MENQEVVNQL AGFEVKVSGQ PLSKLPEDLY IPPDALRVFL EAFEGPLDLL LYLIKKHNID
ILDIPIAEIT RQYMQFVDLM REMRIELAAE YLVMAAMLAE IKSRLLLPRP VVEEENEQDP
RAELVRRLQE YERYKKAAYD LDQLPRVGRD TFIADAAVPP MNTAKIHPTA ELPELLNALK
DVLQRASLYN AHSIAREPLS IRERMSRILS LVDKENFIAF TRLFTVEEGR MGVVVTLIAT
LELIRQSVIE LVQAEPFALI HIRAKG