SCPA_EXISA
ID SCPA_EXISA Reviewed; 255 AA.
AC C4L379;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Segregation and condensation protein A {ECO:0000255|HAMAP-Rule:MF_01805};
GN Name=scpA {ECO:0000255|HAMAP-Rule:MF_01805}; OrderedLocusNames=EAT1b_0445;
OS Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b).
OC Bacteria; Firmicutes; Bacilli; Bacillales;
OC Bacillales Family XII. Incertae Sedis; Exiguobacterium;
OC unclassified Exiguobacterium.
OX NCBI_TaxID=360911;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1283 / AT1b;
RX PubMed=21460088; DOI=10.1128/jb.00303-11;
RA Vishnivetskaya T.A., Lucas S., Copeland A., Lapidus A., Glavina del Rio T.,
RA Dalin E., Tice H., Bruce D.C., Goodwin L.A., Pitluck S., Saunders E.,
RA Brettin T., Detter C., Han C., Larimer F., Land M.L., Hauser L.J.,
RA Kyrpides N.C., Ovchinnikova G., Kathariou S., Ramaley R.F., Rodrigues D.F.,
RA Hendrix C., Richardson P., Tiedje J.M.;
RT "Complete genome sequence of the Thermophilic Bacterium Exiguobacterium sp.
RT AT1b.";
RL J. Bacteriol. 193:2880-2881(2011).
CC -!- FUNCTION: Participates in chromosomal partition during cell division.
CC May act via the formation of a condensin-like complex containing Smc
CC and ScpB that pull DNA away from mid-cell into both cell halves.
CC {ECO:0000255|HAMAP-Rule:MF_01805}.
CC -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC Smc. The presence of the three proteins is required for the association
CC of the complex with DNA. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01805}.
CC Note=Associated with two foci at the outer edges of the nucleoid region
CC in young cells, and at four foci within both cell halves in older
CC cells. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000255|HAMAP-
CC Rule:MF_01805}.
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DR EMBL; CP001615; ACQ69377.1; -; Genomic_DNA.
DR RefSeq; WP_012726496.1; NC_012673.1.
DR AlphaFoldDB; C4L379; -.
DR SMR; C4L379; -.
DR STRING; 360911.EAT1b_0445; -.
DR EnsemblBacteria; ACQ69377; ACQ69377; EAT1b_0445.
DR KEGG; eat:EAT1b_0445; -.
DR eggNOG; COG1354; Bacteria.
DR HOGENOM; CLU_038686_3_1_9; -.
DR OMA; YLVMAAM; -.
DR OrthoDB; 959677at2; -.
DR Proteomes; UP000000716; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01805; ScpA; 1.
DR InterPro; IPR003768; ScpA.
DR PANTHER; PTHR33969; PTHR33969; 1.
DR Pfam; PF02616; SMC_ScpA; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW Reference proteome.
FT CHAIN 1..255
FT /note="Segregation and condensation protein A"
FT /id="PRO_1000215946"
SQ SEQUENCE 255 AA; 29860 MW; 4099D0E1961AF705 CRC64;
MEAYNVKIDT FEGPLDLLLH LIGKMEIDIV DISVAEVTDQ YVGYIRTMQK FELDVASEYL
VMAATLLQLK SKQLLPPVPV EDEEVPDFSE EPTREGLIRQ LIEYKAYKEA VVFMREQEEH
RLELYTRPGE DLTTYMSEEV SKYDGPLNFS DLLHAYSKMI ERKRWKERRK KTIKREERTL
EEQMTRLHEH VSSTRQTSFF AFFVERPNVS DLVVTFMALL ELIKLRIVET KQLDQDIQIS
FIEASKKGDE AVAVL