ID   SCPA_MACCJ              Reviewed;         238 AA.
AC   B9E6N3;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Segregation and condensation protein A {ECO:0000255|HAMAP-Rule:MF_01805};
GN   Name=scpA {ECO:0000255|HAMAP-Rule:MF_01805}; OrderedLocusNames=MCCL_1144;
OS   Macrococcus caseolyticus (strain JCSC5402).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Macrococcus.
OX   NCBI_TaxID=458233;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC5402;
RX   PubMed=19074389; DOI=10.1128/jb.01058-08;
RA   Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K.;
RT   "Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402,
RT   reflecting the ancestral genome of the human-pathogenic staphylococci.";
RL   J. Bacteriol. 191:1180-1190(2009).
CC   -!- FUNCTION: Participates in chromosomal partition during cell division.
CC       May act via the formation of a condensin-like complex containing Smc
CC       and ScpB that pull DNA away from mid-cell into both cell halves.
CC       {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC       the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC       Smc. The presence of the three proteins is required for the association
CC       of the complex with DNA. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01805}.
CC       Note=Associated with two foci at the outer edges of the nucleoid region
CC       in young cells, and at four foci within both cell halves in older
CC       cells. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01805}.
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DR   EMBL; AP009484; BAH17851.1; -; Genomic_DNA.
DR   RefSeq; WP_012657049.1; NC_011999.1.
DR   AlphaFoldDB; B9E6N3; -.
DR   SMR; B9E6N3; -.
DR   STRING; 458233.MCCL_1144; -.
DR   EnsemblBacteria; BAH17851; BAH17851; MCCL_1144.
DR   KEGG; mcl:MCCL_1144; -.
DR   eggNOG; COG1354; Bacteria.
DR   HOGENOM; CLU_038686_3_1_9; -.
DR   OMA; YLVMAAM; -.
DR   OrthoDB; 959677at2; -.
DR   Proteomes; UP000001383; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.580; -; 1.
DR   HAMAP; MF_01805; ScpA; 1.
DR   InterPro; IPR003768; ScpA.
DR   InterPro; IPR023093; ScpA-like_C.
DR   PANTHER; PTHR33969; PTHR33969; 1.
DR   Pfam; PF02616; SMC_ScpA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW   Reference proteome.
FT   CHAIN           1..238
FT                   /note="Segregation and condensation protein A"
FT                   /id="PRO_1000187565"
SQ   SEQUENCE   238 AA;  28134 MW;  52FF3CFD40C187F3 CRC64;
     MYEVKLASFH GPLDLLLHLI KQYEIDIYDI SMKILTEQYI NYIKDVTDLD INVHGDYLVM
     ASELLRIKSR MLLPESTETV EETEDPREGL MNQLIEYQNY RMLAEILNEK KKEEEKYFIK
     RGNDLSRFEK VDTSLELELV DLITAYYKAK QRQHVVKPTI SMARDTYSIE DATKNIIENL
     QQKQSITFAD FVTFSETKTQ IVTLFMALLE LMKTETVKIR QERTFGDIYI ERGRRYNG