ID   SCPA_MALP2              Reviewed;         291 AA.
AC   Q8EX12;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Segregation and condensation protein A {ECO:0000255|HAMAP-Rule:MF_01805};
GN   Name=scpA {ECO:0000255|HAMAP-Rule:MF_01805}; OrderedLocusNames=MYPE380;
OS   Malacoplasma penetrans (strain HF-2) (Mycoplasma penetrans).
OC   Bacteria; Tenericutes; Mycoplasmoidales; Mycoplasmoidaceae; Malacoplasma.
OX   NCBI_TaxID=272633;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HF-2;
RX   PubMed=12466555; DOI=10.1093/nar/gkf667;
RA   Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K.,
RA   Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.;
RT   "The complete genomic sequence of Mycoplasma penetrans, an intracellular
RT   bacterial pathogen in humans.";
RL   Nucleic Acids Res. 30:5293-5300(2002).
CC   -!- FUNCTION: Participates in chromosomal partition during cell division.
CC       May act via the formation of a condensin-like complex containing Smc
CC       and ScpB that pull DNA away from mid-cell into both cell halves.
CC       {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC       the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC       Smc. The presence of the three proteins is required for the association
CC       of the complex with DNA. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01805}.
CC       Note=Associated with two foci at the outer edges of the nucleoid region
CC       in young cells, and at four foci within both cell halves in older
CC       cells. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01805}.
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DR   EMBL; BA000026; BAC43828.1; -; Genomic_DNA.
DR   RefSeq; WP_011076864.1; NC_004432.1.
DR   AlphaFoldDB; Q8EX12; -.
DR   SMR; Q8EX12; -.
DR   STRING; 272633.26453496; -.
DR   PRIDE; Q8EX12; -.
DR   EnsemblBacteria; BAC43828; BAC43828; BAC43828.
DR   KEGG; mpe:MYPE380; -.
DR   eggNOG; COG1354; Bacteria.
DR   HOGENOM; CLU_038686_3_0_14; -.
DR   OMA; QIMSIEE; -.
DR   Proteomes; UP000002522; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   HAMAP; MF_01805; ScpA; 1.
DR   InterPro; IPR003768; ScpA.
DR   PANTHER; PTHR33969; PTHR33969; 1.
DR   Pfam; PF02616; SMC_ScpA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW   Reference proteome.
FT   CHAIN           1..291
FT                   /note="Segregation and condensation protein A"
FT                   /id="PRO_0000211096"
SQ   SEQUENCE   291 AA;  34635 MW;  3AA7FB0F729A4C76 CRC64;
     MNDNNNNNEF KPENLESLNN TEFHISIKDI TGKEFNGPFE LFYSLIKERK MDILNINLVE
     VIQLYVDYIN NYLTKLKIDD LTEYLLMATY LLEQKSKRIL PSMDTEEKIS KDIERDKYIQ
     RLLVYKQYQE IVPKLMEKLE RRSRMFEKPT QSGEDKESLL KEFQDNSYVP AMDLDVILKA
     MQKVYLKLVT TKKTKSPKDN VKLIDVSEIS IDDVEKEIRE FLEPFPHLYK ISFMDYFKNI
     PDEKFTKRYF VVAFVAILVL VRNGHIQLEQ NSSDENIFIV KIDKEVESNE Y