ID   SCPA_MYCGE              Reviewed;         471 AA.
AC   P47455;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Segregation and condensation protein A;
GN   Name=scpA; OrderedLocusNames=MG213;
OS   Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS   (Mycoplasmoides genitalium).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=243273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
CC   -!- FUNCTION: Participates in chromosomal partition during cell division.
CC       May act via the formation of a condensin-like complex containing Smc
CC       and ScpB that pull DNA away from mid-cell into both cell halves (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC       the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC       Smc. The presence of the three proteins is required for the association
CC       of the complex with DNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Associated with two
CC       foci at the outer edges of the nucleoid region in young cells, and at
CC       four foci within both cell halves in older cells. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000305}.
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DR   EMBL; L43967; AAC71432.1; -; Genomic_DNA.
DR   PIR; E64223; E64223.
DR   RefSeq; WP_010869374.1; NC_000908.2.
DR   AlphaFoldDB; P47455; -.
DR   STRING; 243273.MG_213; -.
DR   EnsemblBacteria; AAC71432; AAC71432; MG_213.
DR   KEGG; mge:MG_213; -.
DR   eggNOG; COG0262; Bacteria.
DR   eggNOG; COG1354; Bacteria.
DR   HOGENOM; CLU_538423_0_0_14; -.
DR   OMA; DDELYIC; -.
DR   OrthoDB; 710856at2; -.
DR   BioCyc; MGEN243273:G1GJ2-249-MON; -.
DR   Proteomes; UP000000807; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   InterPro; IPR003768; ScpA.
DR   PANTHER; PTHR33969; PTHR33969; 1.
DR   Pfam; PF02616; SMC_ScpA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW   Reference proteome.
FT   CHAIN           1..471
FT                   /note="Segregation and condensation protein A"
FT                   /id="PRO_0000211094"
FT   REGION          143..471
FT                   /note="ScpA"
SQ   SEQUENCE   471 AA;  54829 MW;  9531DEC11D790FE2 CRC64;
     MISLIFDKSN SFNPQLCVEL LNHFKVVMLT KTIVVDYPSF QAWKAQLKPF KLAVFSDNLQ
     TELTPNSKLT VFNNYQQLLV DNNDLIIFAT PTLVQLFDNE IDQLIVINPT SKSKDQFNCN
     WNDFVLIKQT NFKNHQVGYF DKKSSYEPPF TVVTDHFFGN LTDLFSLLVD KKVSVNDVDI
     GLISLQYLNI IANYTNKKAI EKITDYLVIT SKILAKKADN LLNDHQEESV LEYDLATNNF
     RDKMIANLVE HKRYCDSLGE FEKLRVNRLA YFSKANEMEQ FIKTANDQLV TVEDQLPNYI
     SVLKLFHAMN KLLEMRLSSL LTNKNITIKE LSVEQVQKEL VLAIKQFNYQ TVSLKRVLLK
     LNHPISLMYF VTAFVALLVL LNNQVIGLEQ KDYHSELYIF LLDENQLKTF QESPDEMVKR
     IQAQQQQNEL IIAKNKQLRA IKNKQKRADY LKKKYGENYL DKTNLKDENN N