ID   SCPA_STAA8              Reviewed;         243 AA.
AC   Q2FY76;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Segregation and condensation protein A {ECO:0000255|HAMAP-Rule:MF_01805};
GN   Name=scpA {ECO:0000255|HAMAP-Rule:MF_01805};
GN   OrderedLocusNames=SAOUHSC_01589;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Participates in chromosomal partition during cell division.
CC       May act via the formation of a condensin-like complex containing Smc
CC       and ScpB that pull DNA away from mid-cell into both cell halves.
CC       {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC       the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC       Smc. The presence of the three proteins is required for the association
CC       of the complex with DNA. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01805}.
CC       Note=Associated with two foci at the outer edges of the nucleoid region
CC       in young cells, and at four foci within both cell halves in older
CC       cells. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01805}.
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DR   EMBL; CP000253; ABD30668.1; -; Genomic_DNA.
DR   RefSeq; WP_000273371.1; NZ_LS483365.1.
DR   RefSeq; YP_500104.1; NC_007795.1.
DR   AlphaFoldDB; Q2FY76; -.
DR   SMR; Q2FY76; -.
DR   STRING; 1280.SAXN108_1518; -.
DR   EnsemblBacteria; ABD30668; ABD30668; SAOUHSC_01589.
DR   GeneID; 3920005; -.
DR   KEGG; sao:SAOUHSC_01589; -.
DR   PATRIC; fig|93061.5.peg.1446; -.
DR   eggNOG; COG1354; Bacteria.
DR   HOGENOM; CLU_038686_3_1_9; -.
DR   OMA; YLVMAAM; -.
DR   PRO; PR:Q2FY76; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.580; -; 1.
DR   HAMAP; MF_01805; ScpA; 1.
DR   InterPro; IPR003768; ScpA.
DR   InterPro; IPR023093; ScpA-like_C.
DR   PANTHER; PTHR33969; PTHR33969; 1.
DR   Pfam; PF02616; SMC_ScpA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW   Reference proteome.
FT   CHAIN           1..243
FT                   /note="Segregation and condensation protein A"
FT                   /id="PRO_1000069977"
SQ   SEQUENCE   243 AA;  28671 MW;  49630DB4A407D30D CRC64;
     MYEVKLDAFN GPLDLLLHLI QKFEIDIYDI PMQALTEQYM QYVHAMKQLE INIASEYLVL
     ASELLMIKSK MLLPQSTSDM DVDDDPREDL VGRLIEYQNY KEYTAILNDM KEERDFYFTK
     RPTDLSHLET DESWDPNHTI DLTELIVAYQ RVKNRVELNT PKSVEIRKET FTIQQATEQV
     TSRLKDKDHF NFFSLFTFSE PIEQVVTHFL AILEMSKAGI INIEQQRNFE DINIIRGVNY
     HFG