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ABD18_MOUSE
ID   ABD18_MOUSE             Reviewed;         464 AA.
AC   Q8C1A9; Q3TQS7; Q562E0; Q8C0I3;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Protein ABHD18 {ECO:0000305};
DE   AltName: Full=Alpha/beta hydrolase domain-containing protein 18 {ECO:0000305};
DE            Short=Abhydrolase domain-containing protein 18 {ECO:0000312|MGI:MGI:1915468};
DE   Flags: Precursor;
GN   Name=Abhd18 {ECO:0000312|MGI:MGI:1915468};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC   STRAIN=C57BL/6J; TISSUE=Amnion, Egg, Skin, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Molar;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q8C1A9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8C1A9-2; Sequence=VSP_027896;
CC       Name=3;
CC         IsoId=Q8C1A9-3; Sequence=VSP_027895;
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR   EMBL; AK028580; BAC26016.1; -; mRNA.
DR   EMBL; AK031032; BAC27223.1; -; mRNA.
DR   EMBL; AK163334; BAE37305.1; -; mRNA.
DR   EMBL; AK169375; BAE41123.1; -; mRNA.
DR   EMBL; BC092533; AAH92533.2; -; mRNA.
DR   CCDS; CCDS38422.2; -. [Q8C1A9-1]
DR   RefSeq; NP_080898.2; NM_026622.3. [Q8C1A9-1]
DR   RefSeq; XP_017175080.1; XM_017319591.1. [Q8C1A9-1]
DR   AlphaFoldDB; Q8C1A9; -.
DR   STRING; 10090.ENSMUSP00000124430; -.
DR   ESTHER; mouse-Q8C1A9; ABHD18.
DR   GlyGen; Q8C1A9; 1 site.
DR   iPTMnet; Q8C1A9; -.
DR   PhosphoSitePlus; Q8C1A9; -.
DR   EPD; Q8C1A9; -.
DR   MaxQB; Q8C1A9; -.
DR   PaxDb; Q8C1A9; -.
DR   PRIDE; Q8C1A9; -.
DR   ProteomicsDB; 285959; -. [Q8C1A9-1]
DR   ProteomicsDB; 285960; -. [Q8C1A9-2]
DR   ProteomicsDB; 285961; -. [Q8C1A9-3]
DR   Antibodypedia; 64973; 86 antibodies from 17 providers.
DR   Ensembl; ENSMUST00000108077; ENSMUSP00000103712; ENSMUSG00000037818. [Q8C1A9-1]
DR   Ensembl; ENSMUST00000108078; ENSMUSP00000103713; ENSMUSG00000037818. [Q8C1A9-1]
DR   Ensembl; ENSMUST00000159774; ENSMUSP00000124430; ENSMUSG00000037818. [Q8C1A9-1]
DR   GeneID; 269423; -.
DR   KEGG; mmu:269423; -.
DR   UCSC; uc008pbw.2; mouse. [Q8C1A9-1]
DR   UCSC; uc008pbz.2; mouse. [Q8C1A9-3]
DR   CTD; 80167; -.
DR   MGI; MGI:1915468; Abhd18.
DR   VEuPathDB; HostDB:ENSMUSG00000037818; -.
DR   eggNOG; KOG1551; Eukaryota.
DR   GeneTree; ENSGT00390000014635; -.
DR   HOGENOM; CLU_035640_0_0_1; -.
DR   InParanoid; Q8C1A9; -.
DR   OMA; LLNWCEQ; -.
DR   OrthoDB; 1294532at2759; -.
DR   PhylomeDB; Q8C1A9; -.
DR   TreeFam; TF314683; -.
DR   BioGRID-ORCS; 269423; 3 hits in 39 CRISPR screens.
DR   ChiTaRS; Abhd18; mouse.
DR   PRO; PR:Q8C1A9; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q8C1A9; protein.
DR   Bgee; ENSMUSG00000037818; Expressed in heart and 61 other tissues.
DR   ExpressionAtlas; Q8C1A9; baseline and differential.
DR   Genevisible; Q8C1A9; MM.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR019149; ABHD18.
DR   PANTHER; PTHR13617; PTHR13617; 1.
DR   Pfam; PF09752; DUF2048; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..464
FT                   /note="Protein ABHD18"
FT                   /id="PRO_0000301961"
FT   CARBOHYD        341
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..272
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:16141072"
FT                   /id="VSP_027895"
FT   VAR_SEQ         1..261
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_027896"
FT   CONFLICT        331
FT                   /note="L -> M (in Ref. 1; BAC27223)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   464 AA;  53168 MW;  DC69352692F3361F CRC64;
     MGVSKLDILY RRLLLTKLFI RGWGRPEDLK RLFEFRKMIG NRERCQNLVS SDYPVHIDKV
     EEQSDCKILD GHFVSPMAHY VPGIMPIESV VARFQFIVPK EWNSRYRPVC IHLAGTGDHH
     YWRRRTLMAR PMIKEARMAS LLLENPYYGC RKPKDQVRSS LKNVSDLFVM GGALILESAA
     LLHWLEREGY GPLGMTGISM GGHMASLAVS NWPKPMPLIP CLSWSTASGV FTTGVLSKSI
     NWRELEKQYY TQTVYEEEII HMLEYCGTDS FKMGHEFMNH LPSNADKLTN LNLVSRTLNL
     DMTDQVVSPK DAKCHKSGKT SISAPSNGQL LQDTAKMECL NQTLSTNKSW FASYNPQSFH
     LLNREQRRSN RQKESLIFMK GVMDECTHVA NFSVPVDPSL IIVVQAKEDA YIPRTGVRSL
     QEIWPGCEIR YLEGGHISAY LFKQGLFRQA IYDAFERFLH KYAN
 
 
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