ID   SCPA_STAES              Reviewed;         243 AA.
AC   Q8CSH0;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Segregation and condensation protein A {ECO:0000255|HAMAP-Rule:MF_01805};
GN   Name=scpA {ECO:0000255|HAMAP-Rule:MF_01805}; OrderedLocusNames=SE_1179;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Participates in chromosomal partition during cell division.
CC       May act via the formation of a condensin-like complex containing Smc
CC       and ScpB that pull DNA away from mid-cell into both cell halves.
CC       {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC       the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC       Smc. The presence of the three proteins is required for the association
CC       of the complex with DNA. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01805}.
CC       Note=Associated with two foci at the outer edges of the nucleoid region
CC       in young cells, and at four foci within both cell halves in older
CC       cells. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01805}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO04778.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE015929; AAO04778.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_764734.1; NC_004461.1.
DR   RefSeq; WP_001831064.1; NC_004461.1.
DR   AlphaFoldDB; Q8CSH0; -.
DR   SMR; Q8CSH0; -.
DR   STRING; 176280.SE_1179; -.
DR   EnsemblBacteria; AAO04778; AAO04778; SE_1179.
DR   GeneID; 50018702; -.
DR   KEGG; sep:SE_1179; -.
DR   PATRIC; fig|176280.10.peg.1150; -.
DR   eggNOG; COG1354; Bacteria.
DR   HOGENOM; CLU_038686_3_1_9; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.580; -; 1.
DR   HAMAP; MF_01805; ScpA; 1.
DR   InterPro; IPR003768; ScpA.
DR   InterPro; IPR023093; ScpA-like_C.
DR   PANTHER; PTHR33969; PTHR33969; 1.
DR   Pfam; PF02616; SMC_ScpA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm.
FT   CHAIN           1..243
FT                   /note="Segregation and condensation protein A"
FT                   /id="PRO_0000211106"
SQ   SEQUENCE   243 AA;  28575 MW;  87CFB4ACB492B048 CRC64;
     MYEVKLDAFN GPLDLLLHLI QKYEIDIYDI PMKALTEQYM QYVHAMNQLE INVASEYLVM
     ASELLMIKSK LLLPQTSIEE DIEEDPREDL VGRLIEYQNY KEYTEILNTM KEERDLYFTK
     HPTDLTHLET NESWDPNQTI DLTELIVAYQ RVKNRVELNT PKSVEIKKET FTIQQATAQV
     TERLKQHESF NFFSLFTFHE PVEQVVTHFL AILEMSKSGI VNIKQTKQFD DIDIIRGVNY
     SIG