ID   SCPA_STRMT              Reviewed;         242 AA.
AC   Q9EUR2;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Segregation and condensation protein A {ECO:0000255|HAMAP-Rule:MF_01805};
GN   Name=scpA {ECO:0000255|HAMAP-Rule:MF_01805};
OS   Streptococcus mitis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=28037;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=476;
RX   PubMed=11763967;
RA   Reichmann P., Hakenbeck R.;
RT   "A XerD recombinase with unusual active site motifs in Streptococcus
RT   pneumoniae.";
RL   J. Mol. Microbiol. Biotechnol. 4:101-110(2002).
CC   -!- FUNCTION: Participates in chromosomal partition during cell division.
CC       May act via the formation of a condensin-like complex containing Smc
CC       and ScpB that pull DNA away from mid-cell into both cell halves.
CC       {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC       the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC       Smc. The presence of the three proteins is required for the association
CC       of the complex with DNA. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01805}.
CC       Note=Associated with two foci at the outer edges of the nucleoid region
CC       in young cells, and at four foci within both cell halves in older
CC       cells. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01805}.
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DR   EMBL; AJ277490; CAC19444.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9EUR2; -.
DR   SMR; Q9EUR2; -.
DR   STRING; 585202.SMSK321_1126; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.580; -; 1.
DR   HAMAP; MF_01805; ScpA; 1.
DR   InterPro; IPR003768; ScpA.
DR   InterPro; IPR023093; ScpA-like_C.
DR   PANTHER; PTHR33969; PTHR33969; 1.
DR   Pfam; PF02616; SMC_ScpA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm.
FT   CHAIN           1..242
FT                   /note="Segregation and condensation protein A"
FT                   /id="PRO_0000211112"
SQ   SEQUENCE   242 AA;  28377 MW;  8D4A6AE2AE1B106F CRC64;
     MDIKLKDFEG PLDLLLHLVS KYKMDIYDVP ITEVIEQYLA YVSTLQAMRL EVTGEYMVMA
     SQLMLIKSRK LLPKVAEVTD LEDDLEQDLL SQIEEYRKFK LLGEHLEAKH QERAQYYSKA
     PRELMYEDAE LVHDKTTIDL FLAFSNILAK KKEEFAQNHT TILRDEYKIE DMMIIVKESL
     TGRDQLRLQD LFKEAQNVQE VITLFLATLE LIKTQELILV QEESFGDIYL MEKKEESQVA
     QS