ID   SCPA_STRPN              Reviewed;         242 AA.
AC   Q97NX5;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Segregation and condensation protein A {ECO:0000255|HAMAP-Rule:MF_01805};
GN   Name=scpA {ECO:0000255|HAMAP-Rule:MF_01805}; OrderedLocusNames=SP_1876;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Participates in chromosomal partition during cell division.
CC       May act via the formation of a condensin-like complex containing Smc
CC       and ScpB that pull DNA away from mid-cell into both cell halves.
CC       {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC       the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC       Smc. The presence of the three proteins is required for the association
CC       of the complex with DNA. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- INTERACTION:
CC       Q97NX5; Q97SE6: gatA; NbExp=2; IntAct=EBI-2207368, EBI-2207039;
CC       Q97NX5; Q97NV3: groES; NbExp=2; IntAct=EBI-2207368, EBI-2206949;
CC       Q97NX5; P0CB75: pyrF; NbExp=3; IntAct=EBI-2207368, EBI-2207109;
CC       Q97NX5; Q97NX6: scpB; NbExp=3; IntAct=EBI-2207368, EBI-2206697;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01805}.
CC       Note=Associated with two foci at the outer edges of the nucleoid region
CC       in young cells, and at four foci within both cell halves in older
CC       cells. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01805}.
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DR   EMBL; AE005672; AAK75948.1; -; Genomic_DNA.
DR   PIR; C95219; C95219.
DR   RefSeq; WP_000351912.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; Q97NX5; -.
DR   SMR; Q97NX5; -.
DR   IntAct; Q97NX5; 4.
DR   STRING; 170187.SP_1876; -.
DR   EnsemblBacteria; AAK75948; AAK75948; SP_1876.
DR   KEGG; spn:SP_1876; -.
DR   eggNOG; COG1354; Bacteria.
DR   OMA; YLVMAAM; -.
DR   PhylomeDB; Q97NX5; -.
DR   BioCyc; SPNE170187:G1FZB-1906-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.580; -; 1.
DR   HAMAP; MF_01805; ScpA; 1.
DR   InterPro; IPR003768; ScpA.
DR   InterPro; IPR023093; ScpA-like_C.
DR   PANTHER; PTHR33969; PTHR33969; 1.
DR   Pfam; PF02616; SMC_ScpA; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm.
FT   CHAIN           1..242
FT                   /note="Segregation and condensation protein A"
FT                   /id="PRO_0000211114"
SQ   SEQUENCE   242 AA;  28300 MW;  A21146077EB7F2D5 CRC64;
     MDIKLKDFEG PLDLLLHLVS KYQMDIYDVP ITEVIEQYLA YVSTLQAMRL EVTGEYMVMA
     SQLMLIKSRK LLPKVAEVTD LGDDLEQDLL SQIEEYRKFK LLGEHLEAKH QERAQYYSKA
     PTELIYEDAE LVHDKTTIDL FLTFSNILAK KKEEFAQNHT TILRDEYKIE DMMIIVKESL
     IGRDQLRLQD LFKEAQNVQE VITLFLATLE LIKTQELILV QEESFGDIYL MEKKEESQVP
     QS