ID   SCPA_STRSV              Reviewed;         236 AA.
AC   A3CPQ7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Segregation and condensation protein A {ECO:0000255|HAMAP-Rule:MF_01805};
GN   Name=scpA {ECO:0000255|HAMAP-Rule:MF_01805}; OrderedLocusNames=SSA_1779;
OS   Streptococcus sanguinis (strain SK36).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=388919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK36;
RX   PubMed=17277061; DOI=10.1128/jb.01808-06;
RA   Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA   Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA   Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT   "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL   J. Bacteriol. 189:3166-3175(2007).
CC   -!- FUNCTION: Participates in chromosomal partition during cell division.
CC       May act via the formation of a condensin-like complex containing Smc
CC       and ScpB that pull DNA away from mid-cell into both cell halves.
CC       {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC       the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC       Smc. The presence of the three proteins is required for the association
CC       of the complex with DNA. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01805}.
CC       Note=Associated with two foci at the outer edges of the nucleoid region
CC       in young cells, and at four foci within both cell halves in older
CC       cells. {ECO:0000255|HAMAP-Rule:MF_01805}.
CC   -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01805}.
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DR   EMBL; CP000387; ABN45162.1; -; Genomic_DNA.
DR   RefSeq; WP_002909093.1; NC_009009.1.
DR   RefSeq; YP_001035712.1; NC_009009.1.
DR   AlphaFoldDB; A3CPQ7; -.
DR   SMR; A3CPQ7; -.
DR   STRING; 388919.SSA_1779; -.
DR   EnsemblBacteria; ABN45162; ABN45162; SSA_1779.
DR   KEGG; ssa:SSA_1779; -.
DR   PATRIC; fig|388919.9.peg.1687; -.
DR   eggNOG; COG1354; Bacteria.
DR   HOGENOM; CLU_038686_3_3_9; -.
DR   OMA; YLVMAAM; -.
DR   OrthoDB; 959677at2; -.
DR   Proteomes; UP000002148; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.580; -; 1.
DR   HAMAP; MF_01805; ScpA; 1.
DR   InterPro; IPR003768; ScpA.
DR   InterPro; IPR023093; ScpA-like_C.
DR   PANTHER; PTHR33969; PTHR33969; 1.
DR   Pfam; PF02616; SMC_ScpA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW   Reference proteome.
FT   CHAIN           1..236
FT                   /note="Segregation and condensation protein A"
FT                   /id="PRO_1000069987"
SQ   SEQUENCE   236 AA;  27437 MW;  17D98EE35216756D CRC64;
     MDIKLKDFEG PLDLLLHLVS KYQVDIYDVP ITEVIEQYLA YVATLQAMKL EVTGEYMVMA
     SQLMLIKSRK LLPKVADNAE LEDDLEQDLL SQIEEYRRFK LLGEKMSLQH DDRALYYSKP
     KLELVYEDAE LLHDKSTIDL FLAFSKVIAK KQEEFSKSHT TIVRDEYKIE DMMEVVRQRC
     AGKSRLALQE IFAETKDMNE VITLFLATLE LVKVQEVQVI QEENFGNIYL VGRGNE