ID   ABD18_RAT               Reviewed;         464 AA.
AC   Q4V7A8; Q5RJK2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Protein ABHD18 {ECO:0000305};
DE   AltName: Full=Alpha/beta hydrolase domain-containing protein 18 {ECO:0000305};
DE            Short=Abhydrolase domain-containing protein 18 {ECO:0000312|RGD:1563987};
DE   Flags: Precursor;
GN   Name=Abhd18 {ECO:0000312|RGD:1563987};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 98-464.
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH86604.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AABR03014994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03016806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC086604; AAH86604.1; ALT_INIT; mRNA.
DR   EMBL; BC098046; AAH98046.1; -; mRNA.
DR   RefSeq; NP_001020210.2; NM_001025039.2.
DR   AlphaFoldDB; Q4V7A8; -.
DR   STRING; 10116.ENSRNOP00000059389; -.
DR   ESTHER; rat-cd029; ABHD18.
DR   CarbonylDB; Q4V7A8; -.
DR   GlyGen; Q4V7A8; 1 site.
DR   PaxDb; Q4V7A8; -.
DR   GeneID; 499602; -.
DR   KEGG; rno:499602; -.
DR   UCSC; RGD:1563987; rat.
DR   CTD; 80167; -.
DR   RGD; 1563987; Abhd18.
DR   eggNOG; KOG1551; Eukaryota.
DR   InParanoid; Q4V7A8; -.
DR   OrthoDB; 1294532at2759; -.
DR   PhylomeDB; Q4V7A8; -.
DR   TreeFam; TF314683; -.
DR   PRO; PR:Q4V7A8; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR019149; ABHD18.
DR   PANTHER; PTHR13617; PTHR13617; 1.
DR   Pfam; PF09752; DUF2048; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..464
FT                   /note="Protein ABHD18"
FT                   /id="PRO_0000301962"
FT   CARBOHYD        341
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        149..151
FT                   /note="ILL -> GCR (in Ref. 2; AAH98046)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   464 AA;  53235 MW;  A039115352B2A91B CRC64;
     MGVSKLDILY RRLLLTKLFI RGWGRPEDLK RLFEFRKMIG NRERCQNLVS SDYPVHIDKV
     EEQSDCKILD GHFVSPMAHY VPGIMPIESV IARFQFIVPK EWNSRYRPVC IHLAGTGDHH
     YWRRRTLMAR PMIKEARMAS LLLENPYYIL LKPKDQVRSS LKNVSDLFVM GGALILESAA
     LLHWLEREGY GPLGMTGISM GGHMASLAVS NWPKPMPLIP CLSWSTASGV FTTGVLSKSI
     NWRELEKQYY TQTVYEEEII HMLEYCGTDS FKMGHEFMKH FPSNEDKLTN LNLVSRTLNL
     DMRDQVVSPK HAECHHSGKA SISATSKGQL LQDTAKVERL NQTLTTNKSC FASYNPQSLH
     LLSREQRRSN LQKESLIFMK GVMDECTHVA NFSVPVDPSL IIVVQAKEDA YIPRTGVRSL
     QEIWPGCEIR YLEGGHISAY LFKQGLFRQA IYDAFERFLH KYAN