BETI_CROS8
ID BETI_CROS8 Reviewed; 202 AA.
AC A7MFA6;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000255|HAMAP-Rule:MF_00768};
GN Name=betI {ECO:0000255|HAMAP-Rule:MF_00768}; OrderedLocusNames=ESA_02047;
OS Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Cronobacter.
OX NCBI_TaxID=290339;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-894;
RX PubMed=20221447; DOI=10.1371/journal.pone.0009556;
RA Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L.,
RA Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A.,
RA Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K.,
RA McClelland M., Forsythe S.J.;
RT "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic
RT hybridization analysis with other Cronobacter species.";
RL PLoS ONE 5:E9556-E9556(2010).
CC -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC glycine betaine. It represses transcription of the choline transporter
CC BetT and the genes of BetAB involved in the synthesis of glycine
CC betaine (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC choline pathway [regulation].
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DR EMBL; CP000783; ABU77298.1; -; Genomic_DNA.
DR RefSeq; WP_004387948.1; NC_009778.1.
DR AlphaFoldDB; A7MFA6; -.
DR SMR; A7MFA6; -.
DR EnsemblBacteria; ABU77298; ABU77298; ESA_02047.
DR GeneID; 45715777; -.
DR KEGG; esa:ESA_02047; -.
DR HOGENOM; CLU_069356_15_4_6; -.
DR OMA; WLAFYAE; -.
DR OrthoDB; 1745184at2; -.
DR UniPathway; UPA00529; -.
DR Proteomes; UP000000260; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00768; HTH_type_BetI; 1.
DR InterPro; IPR039538; BetI_C.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR017757; Tscrpt_rep_BetI.
DR Pfam; PF13977; TetR_C_6; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF48498; SSF48498; 1.
DR TIGRFAMs; TIGR03384; betaine_BetI; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..202
FT /note="HTH-type transcriptional regulator BetI"
FT /id="PRO_1000083563"
FT DOMAIN 8..68
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
FT DNA_BIND 31..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
SQ SEQUENCE 202 AA; 22462 MW; 86CC8BAFB6D9E9B8 CRC64;
MPKVGMQPIR RRQLIDATLS TINDVGINDA TIAQIARRAG VSAGIISHYF KDKNGLLEAT
MRDITRQLRD AVAARLRPLA QASTEARLLA IVEGNFDDTQ VHSAAMKAWL DFWASSMHQP
QLGRLERVSS RRLFSTLAAE FRRELPREQA RLAAHGLASL IDGLWLRAAL SGQPFNLETA
RTLTTQFIRQ QLAGAAPHEK EE